Book ChapterDOI
Immunogenic and Non-immunogenic Cell Death in the Tumor Microenvironment.
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TLDR
How cancer cells hijack aspects of cell death to promote tumor survival, and how anti-cancer treatments that activate immunogenic death modalities give strong and durable clinical efficacy are focused on.Abstract:
The host immune system is continuously exposed to dying cells and has evolved to distinguish between cell death events signaling potential threats and physiological apoptosis that should be tolerated. Tumors can use this distinction to their advantage, promoting apoptotic death of cancer cells to induce tolerance and evasion of immunosurveillance. On the other hand, stimuli that cause immunogenic death of cancer cells can induce an effective anti-tumor immune response. In this chapter we discuss different forms of cell death in the tumor microenvironment, and how these interact with host immune cells to impact tumor progression and cancer therapy. We focus on how cancer cells hijack aspects of cell death to promote tumor survival, and how anti-cancer treatments that activate immunogenic death modalities give strong and durable clinical efficacy.read more
Citations
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Journal ArticleDOI
Metal Drugs and the Anticancer Immune Response.
Bernhard Englinger,Christine Pirker,Petra Heffeter,Alessio Terenzi,Alessio Terenzi,Christian R. Kowol,Christian R. Kowol,Bernhard K. Keppler,Bernhard K. Keppler,Walter Berger +9 more
TL;DR: This review summarizes the promising but still extremely fragmentary knowledge on the interplay of metal drugs with the fidelity of anticancer immune responses but also their role in adverse effects and highlights that, at least in some cases, metal drugs can induce long-lasting antic cancer immune responses.
Journal ArticleDOI
The balance between breast cancer and the immune system: Challenges for prognosis and clinical benefit from immunotherapies.
TL;DR: The role of TILs, TIICs and TLS in breast cancer (BCa); (ii) the different metabolic-based pathways used by immune and breast cancer cells; and (iii) implications for immunotherapy-based strategies in BCa are addressed.
Journal ArticleDOI
Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
Ilgen Mender,Anli Zhang,Zhenhua Ren,Chuanhui Han,Yafang Deng,Silvia Siteni,Huiyu Li,Jiankun Zhu,Aishwarya Vemula,Jerry W. Shay,Yang Xin Fu +10 more
TL;DR: It is shown that treatment with a telomere-targeting drug, 6-thio-2'-deoxyguanosine (6-Thio-dG), leads to tumor regression through innate and adaptive immune-dependent responses in syngeneic and humanized mouse models of telomerase-expressing cancers.
Journal ArticleDOI
Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect.
Nathan Suek,Luis Felipe Campesato,Taha Merghoub,Taha Merghoub,Danny N. Khalil,Danny N. Khalil +5 more
TL;DR: Two therapies targeted at APC activation, TLR9 and CD40 agonists, and their use in the clinic to enhance the abscopal effect are discussed.
Journal ArticleDOI
Cancer-associated adipocytes as immunomodulators in cancer.
TL;DR: In this paper, the authors summarize the primary interplay among CAAs, the immune response and cancer with a focus on the mechanistic aspects of these relationships, and unify our understanding of CAAs with the immune cell function may be an effective method to enhance the efficacy of immunotherapeutic and conventional treatments.
References
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Journal ArticleDOI
Intravenous Infusion of Syngeneic Apoptotic Cells by Photopheresis Induces Antigen-Specific Regulatory T Cells
Akira Maeda,Agatha Schwarz,Kerstin Kernebeck,Nicole Gross,Yoshinori Aragane,David Peritt,Thomas Schwarz +6 more
TL;DR: Data suggest that photopheresis exerts its immunomodulatory effects via the induction of Ag-specific regulatory T cells in mice exposed to 8-MOP plus UVA radiation.
Journal ArticleDOI
Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by Homeodomain Proteins Pbx1 and Prep-1
Elaine Y. Chung,Jianguo Liu,Yoichiro Homma,Yunhua Zhang,Andrea Brendolan,Matilde Saggese,Jihong Han,Roy L. Silverstein,Licia Selleri,Xiaojing Ma +9 more
TL;DR: It is reported that IL-10 production stimulated by apoptotic cells was regulated at the point of transcription in a manner dependent on p38 mitogen-activated protein kinase, partially on the scavenger receptor CD36, and required cell-cell contact but not phagocytosis.
Journal ArticleDOI
Uptake of Apoptotic Antigen-Coupled Cells by Lymphoid Dendritic Cells and Cross-Priming of CD8+ T Cells Produce Active Immune Unresponsiveness
Thomas A. Ferguson,John M. Herndon,Bennett D. Elzey,Thomas S. Griffith,Steve Schoenberger,Douglas R. Green +5 more
TL;DR: The role of Fas/Fas ligand (FasL)-mediated apoptosis is examined by examining the role of trinitrophenyl-coupled splenocytes (TNP-spl) as tolerogen and provides a mechanism for a well-established method of inducing immunologic unresponsiveness.
Journal ArticleDOI
Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues
TL;DR: It is proposed that apoptosis subserves several pro‐tumour functions—trophic, anti‐inflammatory, and immunomodulatory—and it is identified strategies targeting host responses to apoptotic cells as promising modes of future therapies that could be applied to multiple cancer types in which tumour‐cell apoptosis is active.
Journal ArticleDOI
Danger signalling during cancer cell death: origins, plasticity and regulation
TL;DR: The molecular nature, emerging plasticity in the danger signalling mechanisms and immunological impact of known DAMPs in the context of immunogenic cancer cell death are discussed and key effector mechanisms modulating the interface between dying cancer cells and the immune cells are discussed.
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