Journal ArticleDOI
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment.
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TLDR
A comprehensive review of tumor organoid-on-a-chip platforms for studying the interaction between the tumor microenvironment (TME) and the immune system is presented in this article , where different factors of the TME that recent microfluidic in vitro systems reproduce to generate advanced tools to imitate the crosstalk between TME and immune system.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2022-06-01. It has received 18 citations till now. The article focuses on the topics: Medicine & Tumor microenvironment.read more
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Microfluidic platforms integrated with nano-sensors for point-of-care bioanalysis
TL;DR: In this article , a review of recent advances in point-of-care (POC) bioanalysis on nano-sensor-based microfluidic platforms is presented.
Journal ArticleDOI
Recent Advances of Organ-on-a-Chip in Cancer Modeling Research
Xingxing Liu,Qiu-lan Su,Xiaoyu Zhang,Wen An Yang,Junhua Ning,Kangle Jia,Jinlan Xin,Huanling Li,Longfei Yu,Yuheng Liao,Diming Zhang +10 more
TL;DR: The organ-on-chip (OoC) platform, which integrates the technology of 3D cell culture, tissue engineering, and microfluidics, is emerging as a new method to simulate the critical structures of the in vivo tumor microenvironment and functional characteristics as discussed by the authors .
Journal ArticleDOI
Portable in situ temperature‐dependent spectroscopy on a low‐cost microfluidic platform integrated with a battery‐powered thermofoil heater
TL;DR: In this paper , a low-cost microfluidic platform integrated with a flexible heater was developed for in situ temperature-dependent spectroscopic measurement at the point of care.
Portable in situ temperature‐dependent spectroscopy on a low‐cost microfluidic platform integrated with a battery‐powered thermofoil heater
TL;DR: In this paper , a low-cost microfluidic platform integrated with a flexible heater was developed for in situ temperature-dependent spectroscopic measurement at the point of care.
Journal ArticleDOI
Nanomaterials: Breaking through the bottleneck of tumor immunotherapy.
Yue Kang,Shenglong Li +1 more
TL;DR: In this paper , the progress of nanomaterial-based tumor immunotherapy in recent years is reviewed and a theoretical basis for exploring new nanOMC-based immunotherapy strategies is provided.
References
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Journal ArticleDOI
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
Philip W. Kantoff,Celestia S. Higano,N. Shore,E. Roy Berger,Eric J. Small,David F. Penson,Charles H. Redfern,Anna C. Ferrari,Robert Dreicer,Robert B. Sims,Yi Xu,Mark W. Frohlich,Paul F. Schellhammer +12 more
TL;DR: The use of sipuleucel-T prolonged overall survival among men with metastatic castration-resistant prostate cancer and immune responses to the immunizing antigen were observed in patients who received sipuleUcel- T.
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Oncology Meets Immunology: The Cancer-Immunity Cycle
TL;DR: Emerging clinical data suggest that cancer immunotherapy is likely to become a key part of the clinical management of cancer and may be more effective in combination with agents that target other steps of the cycle.
Journal ArticleDOI
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Mikhail Binnewies,Edward W. Roberts,Kelly Kersten,Vincent Chan,Douglas F. Fearon,Miriam Merad,Lisa M. Coussens,Dmitry I. Gabrilovich,Suzanne Ostrand-Rosenberg,Suzanne Ostrand-Rosenberg,Catherine C. Hedrick,Robert H. Vonderheide,Mikael J. Pittet,Rakesh K. Jain,Weiping Zou,T. Kevin Howcroft,Elisa C. Woodhouse,Robert A. Weinberg,Matthew F. Krummel +18 more
TL;DR: By parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient’s tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.
Journal ArticleDOI
Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.
Gabriela Bindea,Bernhard Mlecnik,Bernhard Mlecnik,Bernhard Mlecnik,Marie Tosolini,Marie Tosolini,Marie Tosolini,Amos Kirilovsky,Amos Kirilovsky,Amos Kirilovsky,Maximilian J. Waldner,Anna C. Obenauf,Helen K. Angell,Helen K. Angell,Helen K. Angell,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Anne Berger,Patrick Bruneval,Wolf H. Fridman,Wolf H. Fridman,Wolf H. Fridman,Christoph Becker,Franck Pagès,Michael R. Speicher,Zlatko Trajanoski,Jérôme Galon +30 more
TL;DR: The immune landscape in human colorectal cancer is revealed and the major hallmarks of the microenvironment associated with tumor progression and recurrence are revealed.
Journal ArticleDOI
Microfluidic organs-on-chips
TL;DR: A microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology has great potential to advance the study of tissue development, organ physiology and disease etiology.