Journal ArticleDOI
Immunotherapy of tumors with vaccine based on quail homologous vascular endothelial growth factor receptor-2.
Ji Yan Liu,Yu Quan Wei,Li Yang,Xia Zhao,Ling Tian,Jian Mei Hou,Ting Niu,Fen Liu,Yu Jiang,Bing Hu,Yang Wu,Jing Mei Su,Yan Yan Lou,Qiu Ming He,Yan Jun Wen,Jin Liang Yang,Bing Kan,Yong Qiu Mao,Feng Luo,Feng Peng +19 more
TLDR
It is found that immunotherapy with qVEGFR was effective at protective and therapeutic antitumor immunity in several solid and hematopoietic tumor models in mice, and may provide a vaccine strategy for cancer therapy through the induction of autoimmunity against the growth factor receptor associated with angiogenesis in a cross-reaction with single xenogeneic homologous protein.About:
This article is published in Blood.The article was published on 2003-09-01. It has received 119 citations till now. The article focuses on the topics: Vascular endothelial growth factor A & Angiogenesis.read more
Citations
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Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles.
Changyang Gong,Senyi Deng,Qinjie Wu,Mingli Xiang,Xiawei Wei,Ling Li,Xiang Gao,Bilan Wang,Lu Sun,Yishan Chen,Yuchen Li,Lei Liu,Zhiyong Qian,Yuquan Wei +13 more
TL;DR: Cur micelles were more effective in inhibiting tumor growth and prolonged survival in both subcutaneous and pulmonary metastatic LL/2 tumor models, and suggested that Cur micells may have promising applications in pulmonary carcinoma therapy.
Journal ArticleDOI
Curcumin loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis.
Lei Liu,Lu Sun,Qinjie Wu,Wenhao Guo,Ling Li,Yishan Chen,Yuchen Li,Changyang Gong,Zhiyong Qian,Yuquan Wei +9 more
TL;DR: Polymeric micelles encapsulating Cur were developed with enhanced anti-tumor and anti-metastasis activity on breast tumor, and Cur-M is excellent water-based formulation of Cur which may serve as a candidate for breast cancer therapy.
Journal ArticleDOI
Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model
Yuan Wen,Chun-Ting Wang,Tian-Tai Ma,Zhi-yong Li,Lina Zhou,Bo Mu,Fei Leng,Huashan Shi,Ya-Ou Li,Yuquan Wei +9 more
TL;DR: The results suggest that FAP, a product preferentially expressed by TAF, could function as an effective tumor rejection antigen.
Journal ArticleDOI
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells
Mira Ernkvist,Nathalie Luna Persson,Stéphane Audebert,Patrick Lécine,Indranil Sinha,Miaoliang Liu,Marc Schlueter,Arie Horowitz,Karin Aase,Thomas Weide,Jean-Paul Borg,Arindam Majumdar,Lars Holmgren +12 more
TL;DR: The results indicate that the directional migration of capillaries in the embryo is governed by the Amot:Patj/Mupp1:Syx signaling that controls local GTPase activity.
Journal ArticleDOI
Immunogenic HER-2/neu peptides as tumor vaccines
Constantin N. Baxevanis,Nectaria N. Sotiriadou,Angelos D. Gritzapis,Panagiota A. Sotiropoulou,Sonia A. Perez,Nike T. Cacoullos,Michael Papamichail +6 more
TL;DR: It would be interesting to determine whether abrogation of tolerance to HER-2/neu using appropriate adjuvants and/or peptide analogs may lead to the development of immune responses to hermaphrodite epitopes that can be of relevance to cancer immunotherapy.
References
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Journal ArticleDOI
What is the evidence that tumors are angiogenesis dependent
TL;DR: Method of treating a wound or burn which comprises directly dressing its surface with non-woven fabric comprising staple fibers of spun, regenerated collagen substantially free of telopeptides is disclosed.
Journal ArticleDOI
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.
Fouad Shalaby,Janet Rossant,Janet Rossant,Terry P. Yamaguchi,Terry P. Yamaguchi,Marina Gertsenstein,Xiang-Fu Wu,Xiang-Fu Wu,Martin L. Breitman,Martin L. Breitman,Andre C. Schuh +10 more
TL;DR: The generation of mice deficient in Flk-1 by disruption of the gene using homologous recombination in embryonic stem (ES) cells is reported, indicating that FlK-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo.
Journal ArticleDOI
The expanding universe of T-cell subsets: Th1, Th2 and more
Tim R. Mosmann,Subash Sad +1 more
TL;DR: The increasing number of T-cell subsets defined by cytokine patterns; the differentiation pathways of CD4+ and CD8+ T cells; the contribution of other cell types to these patterns; and the cytokine interactions during infection and pregnancy are discussed.
Journal ArticleDOI
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.
TL;DR: It is shown that expression of an endothelial cell-specific mitogen, vascular endothelial growth factor (VEGF), is induced in astrocytoma cells but is dramatically upregulated in two apparently different subsets of glioblastoma cells, which strongly support the concept that tumour angiogenesis is regulated by paracrine mechanisms and identify VEGF as a potential tumourAngiogenesis factor in vivo.
Journal ArticleDOI
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.
Birgit Millauer,Susanne Wizigmann-Voos,Harald Schnürch,Ricardo Martinez,Niels Møller,Werner Risau,Axel Ullrich +6 more
TL;DR: Investigation of flk-1 receptor tyrosine kinase mRNA expression by in situ hybridization analysis revealed specific association with endothelial cells at all stages of mouse development, suggesting a major role of this ligand-receptor signaling system in vasculogenesis and angiogenesis.
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Yu Quan Wei,Mei Juan Huang,Li Yang,Xia Zhao,Ling Tian,You Lu,Jing Mei Shu,Chong Jiu Lu,Ting Niu,Bin Kang,Yun Qiu Mao,Fen Liu,Yan Jun Wen,Shong Lei,Feng Luo,Li Qun Zhou,Feng Peng,Yu Jiang,Ji Yan Liu,Hao Zhou,Qing Ru Wang,Qiu Ming He,Fei Xiao,Yan Yan Lou,Xing Jiang Xie,Qiu Li,Yang Wu,Zhen Yu Ding,Bin Hu,Min Hu,Wei Zhang +30 more