Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux
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TLDR
It is demonstrated that Fpn can transport zinc and can protect zinc sensitive cells from high zinc toxicity, and posttranslationally regulated by hepcidin-mediated internalization and degradation.About:
This article is published in Blood.The article was published on 2010-11-25 and is currently open access. It has received 111 citations till now. The article focuses on the topics: Zinc toxicity & Ferroportin.read more
Citations
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Journal Article
The Transcription Factor Mtf-1 Is Essential for Basal and Heavy Metal-Induced Metallothionein-I Gene-Expression
TL;DR: Evidence is presented that MTF‐1 itself is a zinc sensor, which exhibits increased DNA binding activity upon zinc treatment, and is essential for metallothionein gene regulation.
Journal ArticleDOI
The taste of heavy metals: gene regulation by MTF-1.
TL;DR: Recent advances in the understanding of MTF-1 regulation are reviewed with a focus on the mechanism underlying heavy metal responsiveness and transcriptional activation mediated by mammalian or Drosophila M TF-1.
Journal ArticleDOI
Ferroportin-mediated iron transport: expression and regulation.
Diane M. Ward,Jerry Kaplan +1 more
TL;DR: Regulation of ferroportin is critical for iron homeostasis as alterations in ferro portin may result in either iron deficiency or iron overload.
Journal ArticleDOI
Manganese homeostasis in the nervous system.
Pan Chen,Sudipta Chakraborty,Somshuvra Mukhopadhyay,Eun Sook Lee,Monica Maria Bastos Paoliello,Aaron B. Bowman,Michael Aschner,Michael Aschner +7 more
TL;DR: This review will focus on current studies related to mechanisms underlying Mn import and export, primarily the Mn transporters, and their function and roles in Mn‐induced neurotoxicity.
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Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice
Matthew Taylor,Aijuan Qu,Erik R. Anderson,Tsutomu Matsubara,Angelical Martin,Frank J. Gonzalez,Yatrik M. Shah +6 more
TL;DR: In mice, expression of the gene that encodes Fpn and its protein levels are regulated by distinct pathways to provide a rapid and sustained response to acute and chronic iron deficiency.
References
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Journal ArticleDOI
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Elizabeta Nemeth,Marie S. Tuttle,Julie Powelson,Michael B. Vaughn,Adriana Donovan,Diane M. Ward,Tomas Ganz,Jerry Kaplan +7 more
TL;DR: It is reported that hepcidin bound to ferroportin in tissue culture cells, leading to decreased export of cellular iron and the posttranslational regulation of ferroports by hePCidin may complete a homeostatic loop.
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Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
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A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation
Andrew T. McKie,Paola Marciani,Andreas Rolfs,Karen Brennan,Kristina Wehr,Dalna Barrow,Silvia Miret,Adrian Bomford,Tim J Peters,Farzin Farzaneh,Matthias A. Hediger,Matthias W. Hentze,Robert J. Simpson +12 more
TL;DR: The isolation and characterization of a novel cDNA (Ireg1) encoding a duodenal protein that is localized to the basolateral membrane of polarized epithelial cells are described and it is concluded that IREG1 represents the long-sought duodental iron export protein and is upregulated in the iron overload disease, hereditary hemochromatosis.
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A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Sherry L. Abboud,David J. Haile +1 more
TL;DR: Data indicate that MTP1 is an iron-regulated membrane-spanning protein that is involved in intracellular iron metabolism.
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