Journal ArticleDOI
Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides.
Dominic Agyei,Michael K. Danquah +1 more
TLDR
The plausibility of manufacturing pharmaceutical-grade bioactive peptides from food proteins; the challenges and some implementable strategies for overcoming those challenges are discussed.About:
This article is published in Biotechnology Advances.The article was published on 2011-05-01. It has received 287 citations till now.read more
Citations
More filters
Journal ArticleDOI
Molecular Docking Studies of a Cyclic Octapeptide-Cyclosaplin from Sandalwood.
Abheepsa Mishra,Satyahari Dey +1 more
TL;DR: The in silico analyses gave the insights of cyclosaplin being a potential apoptosis inducer and protein kinase inhibitor and the possible role ofcyclosaplin in apoptotic cell death.
Journal ArticleDOI
Optimisation of Batch Culture Conditions for Cell-Envelope-Associated Proteinase Production from Lactobacillus delbrueckii subsp. lactis ATCC® 7830™
TL;DR: The batch growth conditions for the production of cell-envelope-associated proteinases have for the first time been studied and optimised in Lactobacillus delbrueckii subsp.
Journal ArticleDOI
Generation of the antimicrobial peptide caseicin A from casein by hydrolysis with thermolysin enzymes
Caitriona M. Guinane,Caitriona M. Guinane,Robert M. Kent,Robert M. Kent,Sarah Norberg,Paula M. O'Connor,Paul D. Cotter,Paul D. Cotter,Colin Hill,Gerald F. Fitzgerald,Catherine Stanton,Catherine Stanton,R. Paul Ross +12 more
TL;DR: In this paper, a bioinformatic analysis predicted that thermolysin (EC 3.4.24.27) and thermolyin-like enzymes (EC3.6.28) are likely candidates to liberate the bioactive peptide from αS1-casein.
Journal ArticleDOI
Papain-Specific Activating Esters in Aqueous Dipeptide Synthesis
Roseri J. A. C. de Beer,Barbara Zarzycka,Michiel Mariman,Helene I. V. Amatdjais-Groenen,Marc J. Mulders,Peter J. L. M. Quaedflieg,Floris L. van Delft,Sander B. Nabuurs,Floris P. J. T. Rutjes +8 more
TL;DR: A set of potential activating esters (Z‐Gly‐Act) was designed, synthesized, and evaluated, and both the benzyl (OBn) and the dimethylaminophenyl (ODmap) esters gave promising results.
Journal ArticleDOI
Downstream Processing of Therapeutic Peptides by Means of Preparative Liquid Chromatography.
Chiara De Luca,Giulio Lievore,Desiree Bozza,Alessandro Buratti,Alberto Cavazzini,Antonio Ricci,Marco Macis,Walter Cabri,Simona Felletti,Martina Catani +9 more
TL;DR: In this article, different modes of chromatography that can cover almost every separation case are reviewed and an outlook to a very recent continuous chromatographic process (namely Multicolumn Countercurrent Solvent Gradient Purification, MCSGP) and future perspectives regarding purification strategies are considered at the end of this review.
References
More filters
Journal ArticleDOI
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.
TL;DR: The role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.
Journal ArticleDOI
Bioactive peptides: Production and functionality
TL;DR: A variety of naturally formed bioactive peptides have been found in fermented dairy products, such as yoghurt, sour milk and cheese as mentioned in this paper, but the health benefits attributed to peptides in these traditional products have, so far, not been established, however.
Journal ArticleDOI
Food-derived peptides with biological activity: from research to food applications.
Rainer Hartmann,Hans Meisel +1 more
TL;DR: Several products are already on the market or under development by food companies that exploit the potential of food-derived bioactive peptides and which ascribe scientifically evidenced health claims to consumption of these functional foods.
Journal ArticleDOI
Development and biological activities of marine-derived bioactive peptides: A review
Se-Kwon Kim,Isuru Wijesekara +1 more
TL;DR: An overview of the bioactive peptides derived from marine organisms and their biological activities with potential applications in different areas is presented.
Journal ArticleDOI
Bioactive peptides and proteins from foods: indication for health effects.
TL;DR: There is evidence for the antihypertensive effects of milk products fermented with Lactobacillus helveticus containing the tripeptides IPP and VPP, which inhibit angiotensin converting enzyme, and for osteoprotective effects by milk basic protein.
Related Papers (5)
Food-derived peptides with biological activity: from research to food applications.
Rainer Hartmann,Hans Meisel +1 more