Innate cellular responses to rotavirus infection.
Reads0
Chats0
TLDR
The current literature describing the detection of rotavirus infection by pattern recognition receptors within host cells, the subsequent molecular mechanisms leading to IFN and cytokine production, and the processes leading to reduced rotav virus replication and the development of protective immunity are reviewed.Abstract:
Rotavirus is a leading cause of severe dehydrating diarrhoea in infants and young children. Following rotavirus infection in the intestine an innate immune response is rapidly triggered. This response leads to the induction of type I and type III interferons (IFNs) and other cytokines, resulting in a reduction in viral replication. Here we review the current literature describing the detection of rotavirus infection by pattern recognition receptors within host cells, the subsequent molecular mechanisms leading to IFN and cytokine production, and the processes leading to reduced rotavirus replication and the development of protective immunity. Rotavirus countermeasures against innate responses, and their roles in modulating rotavirus replication in mice, also are discussed. By linking these different aspects of innate immunity, we provide a comprehensive overview of the host’s first line of defence against rotavirus infection. Understanding these processes is expected to be of benefit in improving strategies to combat rotavirus disease.read more
Citations
More filters
Journal ArticleDOI
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection
Pedro P. Hernandez,Pedro P. Hernandez,Tanel Mahlakõiv,Ines Yang,Vera Schwierzeck,Nam Nguyen,Fabian Guendel,Konrad Gronke,Bernhard Ryffel,Bernhard Ryffel,Bernhard Ryffel,Christoph Hölscher,Laure Dumoutier,Jean-Christophe Renauld,Sebastian Suerbaum,Peter Staeheli,Andreas Diefenbach +16 more
TL;DR: It is suggested that epithelial cells are protected against viral replication by co-option of two evolutionarily related cytokine networks, which may inform the design of novel immunotherapy for viral infections that are sensitive to interferons.
Journal ArticleDOI
Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections
TL;DR: IFN-λ should be regarded as an autonomous virus defense system of the gut mucosa and other epithelial barriers that may have evolved to avoid unnecessarily frequent triggering of the IFN-α/β system which would induce exacerbated inflammation.
Journal ArticleDOI
Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections.
Jian-Da Lin,Ningguo Feng,Ningguo Feng,Adrish Sen,Adrish Sen,Murugabaskar Balan,Hsiang-Chi Tseng,Constance McElrath,Sergey V. Smirnov,Jianya Peng,Linda L. Yasukawa,Linda L. Yasukawa,Russell K. Durbin,Joan E. Durbin,Harry B. Greenberg,Harry B. Greenberg,Sergei V. Kotenko +16 more
TL;DR: A well-orchestrated spatial and temporal tuning of innate antiviral responses in the intestinal tract is revealed where two types of IFNs through distinct patterns of their expression and distinct but overlapping sets of target cells coordinately regulate antiviral defenses against heterologous or homologous rotaviruses with substantially different effectiveness.
Journal ArticleDOI
A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection.
Kapil Saxena,Lukas M. Simon,Xi Lei Zeng,Sarah E. Blutt,Sue E. Crawford,Narayan P. Sastri,Umesh C. Karandikar,Nadim J. Ajami,Nicholas C. Zachos,Olga Kovbasnjuk,Mark Donowitz,Margaret E. Conner,Chad A. Shaw,Mary K. Estes +13 more
TL;DR: Ethelial responses in human small intestinal enteroid cultures from different individuals following infection with human rotavirus (HRV), a model enteric pathogen, are reported, revealing type III IFN as the dominant transcriptional response that activates interferon-stimulated genes, but antagonism of the IFN response negates restriction of HRV replication.
References
More filters
Journal ArticleDOI
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
TL;DR: The identification of a novel protein termed MAVS (mitochondrial antiviral signaling), which mediates the activation of NF-kappaB and IRF 3 in response to viral infection, and implicates a new role of mitochondria in innate immunity.
Journal ArticleDOI
5'-Triphosphate RNA Is the Ligand for RIG-I
Veit Hornung,Jana M. Ellegast,Sarah Kim,Krzysztof Brzózka,Andreas Jung,Hiroki Kato,Hendrik Poeck,Shizuo Akira,Karl-Klaus Conzelmann,Martin Schlee,Stefan Endres,Gunther Hartmann +11 more
TL;DR: It is demonstrated that the 5′-triphosphate end of RNA generated by viral polymerases is responsible for retinoic acid–inducible protein I (RIG-I)–mediated detection of RNA molecules in viruses known to be detected by MDA-5 such as the picornaviruses.
Journal ArticleDOI
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Sergei V. Kotenko,Grant Gallagher,Vitaliy V. Baurin,Anita Lewis-Antes,Meiling Shen,Nital K. Shah,Jerome A. Langer,Faruk Sheikh,Harold Dickensheets,Raymond P. Donnelly +9 more
TL;DR: The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
Journal ArticleDOI
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures.
TL;DR: Applied aspects that arise from an increase in knowledge in this area are described, including vaccine design and manufacture, the development of novel antiviral drugs and the use of IFN-sensitive oncolytic viruses in the treatment of cancer.
Journal ArticleDOI
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
Hiroki Kato,Osamu Takeuchi,Eriko Mikamo-Satoh,Eriko Mikamo-Satoh,Reiko Hirai,Tomoji Kawai,Kazufumi Matsushita,Akane Hiiragi,Terence S. Dermody,Takashi Fujita,Shizuo Akira +10 more
TL;DR: It is shown that the length of dsRNA is important for differential recognition by RIG-I and MDA5, and the Mda5 ligand, polyinosinic-polycytidylic acid, was converted to a Rig-I ligand after shortening of the ds RNA length.
Related Papers (5)
Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3.
Mario Barro,John T. Patton +1 more