Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing
Johan Ulrik Lind,Johan Ulrik Lind,Travis Alexander Busbee,Travis Alexander Busbee,Alexander D. Valentine,Alexander D. Valentine,Francesco S. Pasqualini,Francesco S. Pasqualini,Hongyan Yuan,Hongyan Yuan,Hongyan Yuan,Moran Yadid,Moran Yadid,Sung-Jin Park,Sung-Jin Park,Arda Kotikian,Arda Kotikian,Alexander P. Nesmith,Alexander P. Nesmith,Patrick H. Campbell,Patrick H. Campbell,Joost J. Vlassak,Jennifer A. Lewis,Jennifer A. Lewis,Kevin Kit Parker,Kevin Kit Parker +25 more
Reads0
Chats0
TLDR
Six functional inks are designed, based on piezo-resistive, high conductance, and biocompatible soft materials that enable integration of soft strain gauge sensors within micro-architectures that guide the self-assembly of physio-mimetic laminar cardiac tissues via multi-material 3D printing.Abstract:
Biomedical research has relied on animal studies and conventional cell cultures for decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that recapitulate the structure and function of native tissues in vitro, have emerged as a promising alternative. However, current MPS typically lack integrated sensors and their fabrication requires multi-step lithographic processes. Here, we introduce a facile route for fabricating a new class of instrumented cardiac microphysiological devices via multimaterial three-dimensional (3D) printing. Specifically, we designed six functional inks, based on piezo-resistive, high-conductance, and biocompatible soft materials that enable integration of soft strain gauge sensors within micro-architectures that guide the self-assembly of physio-mimetic laminar cardiac tissues. We validated that these embedded sensors provide non-invasive, electronic readouts of tissue contractile stresses inside cell incubator environments. We further applied these devices to study drug responses, as well as the contractile development of human stem cell-derived laminar cardiac tissues over four weeks.read more
Citations
More filters
Journal ArticleDOI
Recent Progress in Biomimetic Additive Manufacturing Technology: From Materials to Functional Structures.
TL;DR: An overview of recent developments in 3D printing of biomimetic reinforced mechanics, shape changing, and hydrodynamic structures, as well as optical and electrical devices is provided.
Journal ArticleDOI
Organ-on-a-chip devices advance to market
Boyang Zhang,Milica Radisic +1 more
TL;DR: This review traces the history, examines the scientific foundation, envisages the prospect of these renowned organ-on-a-chip technologies, and serves as a guide for new members of this dynamic field to navigate the existing scientific and market space.
Journal ArticleDOI
3D printing for soft robotics - a review.
Jahan Zeb Gul,Memoon Sajid,Muhammad Muqeet Rehman,Ghayas Uddin Siddiqui,Imran Shah,Kyung Hwan Kim,Jae-Wook Lee,Kyung Hyun Choi +7 more
TL;DR: The development of key 3D printing technologies and new materials along with composites for soft robotic applications is investigated and a brief summary of 3D-printed soft devices suitable for medical to industrial applications is included.
Journal ArticleDOI
3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling
TL;DR: This review presents state-of-the-art 3D bioprinting techniques and discusses the choice of cell source and biomaterials for building functional tissue models that can be used for personalized drug screening and disease modeling.
Journal ArticleDOI
The Boom in 3D-Printed Sensor Technology
TL;DR: These achievements demonstrate the successful application of 3D-printing technology in sensor fabrication, and the selected studies deeply explore the potential for creating sensors with higher performance.
References
More filters
Journal ArticleDOI
Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubes
Darren J. Lipomi,Michael Vosgueritchian,Benjamin C. K. Tee,Sondra L. Hellstrom,Jennifer A. Lee,Courtney H. Fox,Zhenan Bao +6 more
TL;DR: Transparent, conducting spray-deposited films of single-walled carbon nanotubes are reported that can be rendered stretchable by applying strain along each axis, and then releasing this strain.
Journal ArticleDOI
Microfluidic organs-on-chips
TL;DR: A microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology has great potential to advance the study of tissue development, organ physiology and disease etiology.
Journal ArticleDOI
Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues
Jordan S. Miller,Kelly R. Stevens,Michael T. Yang,Brendon M. Baker,Duc-Huy T. Nguyen,Daniel M. Cohen,Esteban Toro,Alice A. Chen,Peter A. Galie,Xiang-Qing Yu,Ritika Chaturvedi,Sangeeta N. Bhatia,Sangeeta N. Bhatia,Christopher S. Chen +13 more
TL;DR: 3D printed rigid filament networks of carbohydrate glass are used as a cytocompatible sacrificial template in engineered tissues containing living cells to generate cylindrical networks which could be lined with endothelial cells and perfused with blood under high-pressure pulsatile flow.
Journal ArticleDOI
Direct ink writing of 3D functional materials
TL;DR: The ability to pattern materials in 3D shapes without the need for expensive tooling, dies, or lithographic masks is critical for composites, microfluidics, photonics, and tissue engineering as discussed by the authors.
Journal ArticleDOI
Three-dimensional bioprinting of thick vascularized tissues.
TL;DR: A multimaterial 3D bioprinting method is reported that enables the creation of thick human tissues (>1 cm) replete with an engineered extracellular matrix, embedded vasculature, and multiple cell types that can be actively perfused for long durations.