Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
Panagiotis Mallis,Efstathios Michalopoulos,Theofanis Chatzistamatiou,Catherine Stavropoulos Giokas +3 more
- Vol. 1, Iss: 2, pp 112-139
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TLDR
The broad application of MSCs has emerged their role as key immunomodulatory players, therefore their utilization in many disease situations is full of possibilities for future clinical treatment.Abstract:
Mesenchymal stromal cells (MSCs) are a mesodermal stem cell population, with known self-renewal and multilineage differentiation properties. In the last century, MSCs have been widely used in regenerative medicine and tissue engineering approaches. MSCs initially were isolated from bone marrow aspirates, but currently have been identified in a great number of tissues of the human body. Besides their utilization in regenerative medicine, MSCs possess significant immunoregulatory/immunosuppressive properties, through interaction with the cells of innate and adaptive immunity. MSCs can exert their immunomodulatory properties with either cell-cell contact or via paracrine secretion of molecules, such as cytokines, growth factors and chemokines. Of particular importance, the MSCs’ immunomodulatory properties are explored as promising therapeutic strategies in immune-related disorders, such as autoimmune diseases, graft versus host disease, cancer. MSCs may also have an additional impact on coronavirus disease-19 (COVID-19), by attenuating the severe symptoms of this disorder. Nowadays, a great number of clinical trials, of MSC-mediated therapies are evaluated for their therapeutic potential. In this review, the current knowledge on cellular and molecular mechanisms involved in MSC-mediated immunomodulation were highlighted. Also, the most important aspects, regarding their potential application in immune-related diseases, will be highlighted. The broad application of MSCs has emerged their role as key immunomodulatory players, therefore their utilization in many disease situations is full of possibilities for future clinical treatment.read more
Citations
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Mesenchymal stromal cell delivery as a potential therapeutic strategy against COVID-19: Promising evidence from in vitro results
Panagiotis Mallis,Theofanis Chatzistamatiou,Zetta Dimou,Eirini Sarri,Eleni Georgiou,Maria Salagianni,Vasiliki Triantafyllia,Evangelos Andreakos,Catherine Stavropoulos-Giokas,Efstathios Michalopoulos +9 more
TL;DR: WJ and BM-MSCs successfully produced high levels of immunoregulatory agents, which may efficiently modulate the over-activated immune responses of critically ill COVID-19 patients.
Journal ArticleDOI
The Role of COX-2 and PGE2 in the Regulation of Immunomodulation and Other Functions of Mesenchymal Stromal Cells
TL;DR: In this article, the authors summarize the previous observations regarding the role of PGE2 and COX-2 in the immunomodulatory properties and other vital functions of MSCs.
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Clinical Benefit of Autologous Platelet-Rich Plasma Infusion in Ovarian Function Rejuvenation: Evidence from a Before-After Prospective Pilot Study
TL;DR: In this paper , the intraovarian administration of autologous platelet-rich plasma (PRP) acts beneficially for the stimulation of follicle production in women presenting different forms of ovarian dysfunction.
Journal ArticleDOI
Treatment of Acute Respiratory Distress Syndrome Caused by COVID-19 with Human Umbilical Cord Mesenchymal Stem Cells
T. V. Bukreieva,Hanna Svitina,V. Nikulina,Alyona Vega,Oleksii Chybisov,I. Iu. Shablii,Alina Ustymenko,P. Nemtinov,Galyna Lobyntseva,Inessa Skrypkina,V. A. Shablii +10 more
TL;DR: In this paper , lung functional status, miRNA, and cytokine levels changed following mesenchymal stem cell transplantation in patients with severe COVID-19 pneumonia and their correlation with fibrotic changes in the lung.
Journal ArticleDOI
Improved Repopulation Efficacy of Decellularized Small Diameter Vascular Grafts Utilizing the Cord Blood Platelet Lysate.
Panagiotis Mallis,Dimitrios P. Sokolis,Michalis Katsimpoulas,Alkiviadis Kostakis,Catherine Stavropoulos-Giokas,Efstathios Michalopoulos +5 more
TL;DR: In this paper, the repopulation efficacy of biological vessels, utilizing the cord blood platelet lysate (CBPL), was evaluated using histological, biochemical and biomechanical analysis.
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