Intravenous N-Acetylcysteine Improves Transplant-Free Survival in Early Stage Non-Acetaminophen Acute Liver Failure
William M. Lee,Linda S. Hynan,Lorenzo Rossaro,Robert J. Fontana,R. Todd Stravitz,Anne M. Larson,Timothy J. Davern,Natalie Murray,Timothy M. McCashland,Joan S. Reisch,Patricia R. Robuck +10 more
TLDR
Intravenous NAC improves transplant-free survival in patients with early stage non-acetaminophen-related acute liver failure and typically require emergency liver transplantation.About:
This article is published in Gastroenterology.The article was published on 2009-09-01 and is currently open access. It has received 529 citations till now. The article focuses on the topics: Survival rate & Transplantation.read more
Citations
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ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
Naga Chalasani,Paul H. Hayashi,Herbert L. Bonkovsky,Victor J. Navarro,William M. Lee,Robert J. Fontana +5 more
TL;DR: This ACG Clinical Guideline is presented an evidence-based approach to diagnosis and management of DILI with special emphasis on DILi due to herbal and dietary supplements and DilI occurring in individuals with underlying liver disease.
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Drug-induced acute liver failure: results of a U.S. multicenter, prospective study.
TL;DR: DILI is an uncommon cause of ALF that evolves slowly, affects a disproportionate number of women and minorities, and shows infrequent spontaneous recovery, but transplantation affords excellent survival.
Journal ArticleDOI
Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance
TL;DR: The clinical relevance of celldeath, focusing on biomarkers; the contribution of cell death to drug-induced, viral, and fatty liver disease and liver cancer; and evidence for cell death pathways as therapeutic targets are reviewed.
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EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure.
Julia Wendon,Juan Córdoba,Anil Dhawan,Fin Stolze Larsen,Michael Manns,Frederik Nevens,Didier Samuel,Kenneth J. Simpson,Ilan Yaron,Mauro Bernardi +9 more
TL;DR: The term acute liver failure (ALF) is frequently applied as a generic expression to describe patients presenting with or developing an acute episode of liver dysfunction, however, it refers to a highly specific and rare syndrome, characterised by an acute abnormality of liver blood tests in an individual without underlying chronic liver disease.
Journal ArticleDOI
EASL Clinical Practice Guidelines: Drug-induced liver injury
Raúl J. Andrade,Guruprasad P. Aithal,Einar Björnsson,Neil Kaplowitz,Gerd A. Kullak-Ublick,Dominique Larrey,Tom H. Karlsen +6 more
TL;DR: These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.
References
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Model for end-stage liver disease (MELD) and allocation of donor livers
Russell H. Wiesner,Erick B. Edwards,Richard B. Freeman,Ann M. Harper,Ray Kim,Patrick S. Kamath,Walter K. Kremers,John R. Lake,Todd K. Howard,Robert M. Merion,Robert A. Wolfe,Ruud A.F. Krom,Paul M. Colombani,Paige C. Cottingham,Stephen P. Dunn,John J. Fung,Douglas W. Hanto,Sue V. McDiarmid,John M. Rabkin,Lewis W. Teperman,Jeremiah G. Turcotte,Lynn Rothberg Wegman +21 more
TL;DR: Data suggest that the MELD score is able to accurately predict 3-month mortality among patients with chronic liver disease on the liver waiting list and can be applied for allocation of donor livers.
Journal ArticleDOI
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
George Ostapowicz,Robert J. Fontana,Frank V. Schioødt,Anne M. Larson,Timothy J. Davern,Steven Han,Timothy M. McCashland,A. Obaid Shakil,J. Eileen Hay,Linda S. Hynan,Jeffrey S. Crippin,Andres T. Blei,Grace Samuel,Joan S. Reisch,William M. Lee,Raj Santyanarayana,Cary Caldwell,Lawton Shick,Nathan M. Bass,Smita Rouillard,E Atillasoy,Steven L. Flamm,Kent G. Benner,Hugo R. Rosen,Paul Martin,Rise Stribling,Eugene R. Schiff,Maria Torres,Victor J. Navarro,Brendan M. McGuire,Raymond T. Chung,Diane R. Abraczinskas,Jules L. Dienstag +32 more
TL;DR: The primary aim was to compare presenting clinical features and liver transplantation in patients with acute liver failure related to acetaminophen hepatotoxicity, other drugs, indeterminate factors, and other causes.
Journal ArticleDOI
Early indicators of prognosis in fulminant hepatic failure
TL;DR: The successful use of orthotopic liver transplants in fulminant hepatic failure has created a need for early prognostic indicators to select the patients most likely to benefit at a time when liver transplantation is still feasible.
Journal ArticleDOI
AASLD position paper : the management of acute liver failure
Julie Polson,William M. Lee +1 more
TL;DR: This document has been designated as a Position Paper, since the topic contains more data based on expert opinion than on randomized controlled trials and is thus not considered to have the emphasis and certainty of a Practice Guideline.
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Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
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