Drug-induced acute liver failure: results of a U.S. multicenter, prospective study.
TLDR
DILI is an uncommon cause of ALF that evolves slowly, affects a disproportionate number of women and minorities, and shows infrequent spontaneous recovery, but transplantation affords excellent survival.About:
This article is published in Hepatology.The article was published on 2010-12-01 and is currently open access. It has received 604 citations till now. The article focuses on the topics: Liver transplantation & Liver disease.read more
Citations
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Journal ArticleDOI
ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
Naga Chalasani,Paul H. Hayashi,Herbert L. Bonkovsky,Victor J. Navarro,William M. Lee,Robert J. Fontana +5 more
TL;DR: This ACG Clinical Guideline is presented an evidence-based approach to diagnosis and management of DILI with special emphasis on DILi due to herbal and dietary supplements and DilI occurring in individuals with underlying liver disease.
Journal ArticleDOI
Features and outcomes of 899 patients with drug-induced liver injury: The DILIN prospective study
Naga Chalasani,Herbert L. Bonkovsky,Robert J. Fontana,William M. Lee,Andrew Stolz,Jayant A. Talwalkar,K. Rajendar Reddy,Paul B. Watkins,Victor J. Navarro,Huiman X. Barnhart,Jiezhun Gu,Jose Serrano,Jawad Ahmad,Nancy Bach,Meena B. Bansal,Huiman X. Barnhart,Kimberly L. Beavers,Herbert L. Bonkovsky,Francisco O. Calvo,Charissa Y. Chang,Hari S. Conjeevaram,Gregory E. Conner,Jama M. Darling,Ynto S. de Boer,Douglas T. Dieterich,Frank DiPaola,Francisco A. Durazo,James E. Everhart,Robert J. Fontana,Marwan Ghabril,David Goldstein,Vani Gopalreddy,Priya Grewal,Paul H. Hayashi,Jay H. Hoofnagle,Neil Kaplowitz,Suthat Liangpunsakul,Steven N. Lichtman,Lawrence Liu,Victor Navarro,Joseph A. Odin,Simona Rossi,Mark W. Russo,Thomas D. Schiano,Averell H. Sherker,Raj Vuppalanchi,Paul B. Watkins,Steven Zacks,Amanda Balasco,Kristin Chesney,Audrey Corne,Sherrie Cummings,Gale Groseclose,Alex Hammett,Judy Hooker,Varun Kesar,Sophana Mao,Kenari Marks,Regina McFadden,Yolanda Melgoza,Sherif Mikhail,Susan Milstein,Wendy Morlan,Val Peacock,Nidia Rosado,Tracy Russell,Maricruz Vega,Manisha Verma,Patricia F. Walker,Rachana Yalamanchili,Michelle McClanahan-Crowder,Katherine Galan,Tuan Chau,Kowsalya Ragavan,Hoss Rostami,Carmel Puglisi-Scharenbroich,Rebecca Torrance,Rebekah Van Raaphorst +77 more
TL;DR: In this article, the authors present characteristics and subgroup analyses from the first 1257 patients enrolled in the study, and conclude that there are no differences in outcomes of patients with short vs long latency of DILI.
Journal ArticleDOI
EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure.
Julia Wendon,Juan Córdoba,Anil Dhawan,Fin Stolze Larsen,Michael Manns,Frederik Nevens,Didier Samuel,Kenneth J. Simpson,Ilan Yaron,Mauro Bernardi +9 more
TL;DR: The term acute liver failure (ALF) is frequently applied as a generic expression to describe patients presenting with or developing an acute episode of liver dysfunction, however, it refers to a highly specific and rare syndrome, characterised by an acute abnormality of liver blood tests in an individual without underlying chronic liver disease.
Journal ArticleDOI
EASL Clinical Practice Guidelines: Drug-induced liver injury
Raúl J. Andrade,Guruprasad P. Aithal,Einar Björnsson,Neil Kaplowitz,Gerd A. Kullak-Ublick,Dominique Larrey,Tom H. Karlsen +6 more
TL;DR: These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.
Journal ArticleDOI
Introduction to the revised American Association for the Study of Liver Diseases position paper on acute liver failure 2011
TL;DR: Fulminant Wilson's disease can be diagnosed most effectively not by waiting for copper levels (too slow to obtain) or by obtaining ceruloplasmin levels (low in half of all ALF patients, regardless of etiology), but by simply looking for the more readily available bilirubin level and alkaline phosphatase (ALP; very low).
References
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Journal ArticleDOI
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
George Ostapowicz,Robert J. Fontana,Frank V. Schioødt,Anne M. Larson,Timothy J. Davern,Steven Han,Timothy M. McCashland,A. Obaid Shakil,J. Eileen Hay,Linda S. Hynan,Jeffrey S. Crippin,Andres T. Blei,Grace Samuel,Joan S. Reisch,William M. Lee,Raj Santyanarayana,Cary Caldwell,Lawton Shick,Nathan M. Bass,Smita Rouillard,E Atillasoy,Steven L. Flamm,Kent G. Benner,Hugo R. Rosen,Paul Martin,Rise Stribling,Eugene R. Schiff,Maria Torres,Victor J. Navarro,Brendan M. McGuire,Raymond T. Chung,Diane R. Abraczinskas,Jules L. Dienstag +32 more
TL;DR: The primary aim was to compare presenting clinical features and liver transplantation in patients with acute liver failure related to acetaminophen hepatotoxicity, other drugs, indeterminate factors, and other causes.
Journal ArticleDOI
Early indicators of prognosis in fulminant hepatic failure
TL;DR: The successful use of orthotopic liver transplants in fulminant hepatic failure has created a need for early prognostic indicators to select the patients most likely to benefit at a time when liver transplantation is still feasible.
Journal ArticleDOI
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Anne M. Larson,Julie Polson,Robert J. Fontana,Timothy J. Davern,Ezmina Lalani,Linda S. Hynan,Joan S. Reisch,Frank V. Schiødt,George Ostapowicz,A. Obaid Shakil,William M. Lee +10 more
TL;DR: In conclusion, acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the United States, and education of patients, physicians, and pharmacies to limit high‐risk use settings is recommended.
Journal ArticleDOI
The model for end-stage liver disease (MELD)
Patrick S. Kamath,W. Ray Kim +1 more
TL;DR: The Model for End‐stage Liver Disease was initially created to predict survival in patients with complications of portal hypertension undergoing elective placement of transjugular intrahepatic portosystemic shunts and was validated subsequently as an accurate predictor of survival among different populations of patients with advanced liver disease.
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