Introduction to the revised American Association for the Study of Liver Diseases position paper on acute liver failure 2011
TLDR
Fulminant Wilson's disease can be diagnosed most effectively not by waiting for copper levels (too slow to obtain) or by obtaining ceruloplasmin levels (low in half of all ALF patients, regardless of etiology), but by simply looking for the more readily available bilirubin level and alkaline phosphatase (ALP; very low).About:
This article is published in Hepatology.The article was published on 2012-03-01 and is currently open access. It has received 390 citations till now. The article focuses on the topics: Autoimmune hepatitis & acetaminophen overdose.read more
Citations
More filters
Journal ArticleDOI
Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver
Hendrik Vilstrup,Piero Amodio,Jasmohan S. Bajaj,Jasmohan S. Bajaj,Juan Córdoba,Peter Ferenci,Kevin D. Mullen,Karin Weissenborn,Philip Wong +8 more
TL;DR: The AASLD/EASL Practice Guideline Subcommittee on Hepatic Encephalopathy are: Jayant A. Talwalkar, Hari S. Conjeevaram, Michael Porayko, Raphael B. Merriman, Peter L. Jansen, Fabien Zoulim.
Journal ArticleDOI
Acute-on chronic liver failure
Rajiv Jalan,Pere Ginès,Jody C. Olson,Rajeshwar P. Mookerjee,Richard Moreau,Guadalupe Garcia-Tsao,Vicente Arroyo,Patrick S. Kamath +7 more
TL;DR: In this paper, the authors focus on the current understanding of acute-on-chronic liver failure from the clinical, prognostic and pathophysiological perspectives and indicate potential biomarkers and therapeutic targets for intervention.
Journal ArticleDOI
ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries
TL;DR: The evaluation of hepatocellular injury includes testing for viral hepatitis A, B, and C, assessment for nonalcoholic fatty liver disease and alcoholic liver disease, screening for hereditary hemochromatosis, autoimmune hepatitis, Wilson’s disease, and alpha-1 antitrypsin deficiency.
Journal ArticleDOI
EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure.
Julia Wendon,Juan Córdoba,Anil Dhawan,Fin Stolze Larsen,Michael Manns,Frederik Nevens,Didier Samuel,Kenneth J. Simpson,Ilan Yaron,Mauro Bernardi +9 more
TL;DR: The term acute liver failure (ALF) is frequently applied as a generic expression to describe patients presenting with or developing an acute episode of liver dysfunction, however, it refers to a highly specific and rare syndrome, characterised by an acute abnormality of liver blood tests in an individual without underlying chronic liver disease.
Journal ArticleDOI
High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial
Fin Stolze Larsen,Lars E. Schmidt,Christine Bernsmeier,Allan Rasmussen,Helena Isoniemi,Vishal C. Patel,Evangelos Triantafyllou,William Bernal,Georg Auzinger,Debbie L. Shawcross,Martin Eefsen,Peter Nissen Bjerring,Jens Otto Clemmesen,Krister Höckerstedt,Hans-Jørgen Frederiksen,Bent Adel Hansen,Charalambos G. Antoniades,Julia Wendon +17 more
TL;DR: Treatment with HVP improves outcome in patients with ALF by increasing liver transplantation-free survival by attributable to attenuation of innate immune activation and amelioration of multi-organ dysfunction.
References
More filters
Journal ArticleDOI
The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults.
William A. Knaus,Douglas P. Wagner,Elizabeth A. Draper,Jack E. Zimmerman,Marilyn Bergner,Paulo G. Bastos,Carl A. Sirio,Donaldj Murphy,Ted Lotring,Anne M. Damiano +9 more
TL;DR: The overall predictive accuracy of the first-day APACHE III equation was such that, within 24 h ofICU admission, 95 percent of ICU admissions could be given a risk estimate for hospital death that was within 3 percent of that actually observed.
Journal ArticleDOI
Chronic hepatitis B: Update 2009
Anna S.F. Lok,Brian J. McMahon +1 more
TL;DR: The 2009 update of the American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for Management of Chronic Hepatitis B is now posted online at www.aasld.org, and the recommendation for first-line oral antiviral medications has been changed to tenofovir or entecavir, and adefovir has been moved to second-line Oral antiviral medication.
Journal ArticleDOI
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
George Ostapowicz,Robert J. Fontana,Frank V. Schioødt,Anne M. Larson,Timothy J. Davern,Steven Han,Timothy M. McCashland,A. Obaid Shakil,J. Eileen Hay,Linda S. Hynan,Jeffrey S. Crippin,Andres T. Blei,Grace Samuel,Joan S. Reisch,William M. Lee,Raj Santyanarayana,Cary Caldwell,Lawton Shick,Nathan M. Bass,Smita Rouillard,E Atillasoy,Steven L. Flamm,Kent G. Benner,Hugo R. Rosen,Paul Martin,Rise Stribling,Eugene R. Schiff,Maria Torres,Victor J. Navarro,Brendan M. McGuire,Raymond T. Chung,Diane R. Abraczinskas,Jules L. Dienstag +32 more
TL;DR: The primary aim was to compare presenting clinical features and liver transplantation in patients with acute liver failure related to acetaminophen hepatotoxicity, other drugs, indeterminate factors, and other causes.
Journal ArticleDOI
Early indicators of prognosis in fulminant hepatic failure
TL;DR: The successful use of orthotopic liver transplants in fulminant hepatic failure has created a need for early prognostic indicators to select the patients most likely to benefit at a time when liver transplantation is still feasible.
Related Papers (5)
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
George Ostapowicz,Robert J. Fontana,Frank V. Schioødt,Anne M. Larson,Timothy J. Davern,Steven Han,Timothy M. McCashland,A. Obaid Shakil,J. Eileen Hay,Linda S. Hynan,Jeffrey S. Crippin,Andres T. Blei,Grace Samuel,Joan S. Reisch,William M. Lee,Raj Santyanarayana,Cary Caldwell,Lawton Shick,Nathan M. Bass,Smita Rouillard,E Atillasoy,Steven L. Flamm,Kent G. Benner,Hugo R. Rosen,Paul Martin,Rise Stribling,Eugene R. Schiff,Maria Torres,Victor J. Navarro,Brendan M. McGuire,Raymond T. Chung,Diane R. Abraczinskas,Jules L. Dienstag +32 more