Journal ArticleDOI
IRON ABSORPTION AND LOADING IN β-THALASSÆMIA INTERMEDIA
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TLDR
Iron absorption was strikingly increased and there was a progressive iron loading with increasing age and balance studies indicated that by the time many of these patients reach the third or fourth decades their total iron loads may be of a similar magnitude to those of transfusion-dependent β-thalassaemia homozygotes.About:
This article is published in The Lancet.The article was published on 1979-10-20. It has received 396 citations till now. The article focuses on the topics: Intestinal absorption.read more
Citations
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Current approaches to diagnosis and treatment of celiac disease: An evolving spectrum☆
Alessio Fasano,Carlo Catassi +1 more
TL;DR: The current gold standard for the diagnosis of CD remains histologic confirmation of the intestinal damage in serologically positive individuals, and the keystone treatment of CD patients is a lifelong elimination diet in which food products containing gluten are avoided.
Journal ArticleDOI
Iron-chelating therapy and the treatment of thalassemia
TL;DR: The toxicity of this agent mandates a careful evaluation of the balance between risk and benefit of deferiprone in patients with thalassemia, in most of whom long-term deferoxamine is safe and efficacious therapy.
Journal ArticleDOI
Iron bioavailability and dietary reference values
Richard F. Hurrell,Ines Egli +1 more
TL;DR: It would be timely to develop a range of iron bioavailability factors based not only on diet composition but also on subject characteristics, such as iron status and prevalence of obesity.
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Identification of erythroferrone as an erythroid regulator of iron metabolism
TL;DR: A new hormone, erythroferrone (ERFE), is identified that mediates hepcidin suppression during stress erythropoiesis, and is greatly increased in Hbbth3/+ mice with thalassemia intermedia, where it contributes to the suppression of hePCidin and the systemic iron overload characteristic of this disease.
Journal ArticleDOI
Systemic iron homeostasis
TL;DR: This review summarizes and discusses recent progress in molecular characterization of systemic iron homeostasis and its disorders, and identifies areas for further investigation.
References
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Book
The thalassaemia syndromes
TL;DR: This work focuses on the treatment and management of thalassaemia withmental retardation or Myelodysplasia, and the many and Diverse Routes to the authors' Current Understanding of the ThalassAemia Syndromes.
The thalassaemia syndromes.
TL;DR: In this article, the authors present a review of the current understanding of the thalassaemia Syndromes and its relationship to other inherited diseases of Haemoglobin. But they do not discuss the treatment and management of these diseases.
Journal ArticleDOI
The effect of tea on iron absorption.
TL;DR: Drinking tannin-containing beverages such as tea with meals may contribute to the pathogenesis of iron deficiency if the diet consists largely of vegetable foodstuffs.
Journal ArticleDOI
Continuous Subcutaneous Administration of Deferoxamine in Patients with Iron Overload
Richard D. Propper,Richard D. Propper,Barry J. Cooper,Barry J. Cooper,Robert R. Rufo,Robert R. Rufo,Arthur W. Nienhuis,Arthur W. Nienhuis,W. French Anderson,W. French Anderson,H. Franklin Bunn,H. Franklin Bunn,Amnon Rosenthal,David G. Nathan,David G. Nathan +14 more
TL;DR: Constant subcutaneous deferoxamine administration may prove to be an effective and practical means of eliminating large quantities of iron in siderosis.
Journal ArticleDOI
Food iron absorption measured by an extrinsic tag.
TL;DR: The extrinsic tag provided a valid measure of absorption despite marked differences in the iron status of the subject, and with wide changes in absorption imposed by adding desferrioxamine or ascorbic acid to the test meal.
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