Journal ArticleDOI
Let's go mucosal: communication on slippery ground.
Per Brandtzaeg,Reinhard Pabst +1 more
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TLDR
Mucosal immunology is increasingly gaining attention as an area of great potential for the development of vaccines and immunotherapy, however, some immunologists confuse this field by neglecting recommended and well-defined terminology.About:
This article is published in Trends in Immunology.The article was published on 2004-11-01. It has received 304 citations till now. The article focuses on the topics: Mucosal immunology.read more
Citations
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Amino acids and immune function
TL;DR: Increasing evidence shows that dietary supplementation of specific amino acids to animals and humans with malnutrition and infectious disease enhances the immune status, thereby reducing morbidity and mortality.
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Immunity, Inflammation, and Allergy in the Gut
TL;DR: In both mouse and man, mutations in genes that control innate immune recognition, adaptive immunity, and epithelial permeability are all associated with gut inflammation, which suggests that perturbing homeostasis between gut antigens and host immunity represents a critical determinant in the development of gut inflammation and allergy.
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Lymphoid neogenesis in chronic inflammatory diseases
TL;DR: Recent progress in several aspects of lymphoid neogenesis are discussed, focusing on the similarities with lymphoid tissue development, the mechanisms of induction, functional competence and pathophysiological significance, and how these issues might eventually lead to new strategies to target immunopathological processes.
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Mucosal Dendritic Cells
TL;DR: Progress is highlighted in understanding of how mucosal DCs process external information and direct appropriate responses by mobilizing various cells of the innate and adaptive immune systems to achieve homeostasis and protection.
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Teleost intestinal immunology.
Jan H.W.M. Rombout,Jan H.W.M. Rombout,Luigi Abelli,Simona Picchietti,Giuseppe Scapigliati,Viswanath Kiron +5 more
TL;DR: The recent development of gnotobiotic fish models may be very helpful to study the immune effects of microbiota and probiotics in teleosts, and much more attention has to be paid to the immune mechanisms behind these effects.
References
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Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria.
Maria Rescigno,Matteo Urbano,Barbara Valzasina,Maura Francolini,Gianluca Rotta,Roberto Bonasio,Francesca Granucci,Jean Pierre Kraehenbuhl,Paola Ricciardi-Castagnoli +8 more
TL;DR: A new mechanism for bacterial uptake in the mucosa tissues that is mediated by dendritic cells (DCs) is reported, which open the tight junctions between epithelial cells, send dendrites outside the epithelium and directly sample bacteria.
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Anatomical basis of tolerance and immunity to intestinal antigens
TL;DR: The unique aspects of the local microenvironment of the intestinal immune system are reviewed and how these promote the development of regulatory responses that ensure the maintenance of homeostasis in the gut are discussed.
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A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria
Andrew J. Macpherson,Dominique Gatto,Elizabeth Sainsbury,Gregory R. Harriman,Hans Hengartner,Rolf M. Zinkernagel +5 more
TL;DR: The IgA against intestinal commensal bacterial antigens was analyzed; it was not simply "natural antibody" but was specifically induced and responded to antigenic changes within an established gut flora.
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Characteristics of an immune system common to certain external secretions
TL;DR: The γ1A present in saliva and colostrum exists largely in the form of higher polymers, the major component of which has a sedimentation coefficient of 11S, and its properties including the local production of a distinctive type of antibody separate it from the "systemic" system responsible for the production of circulating antibody.
Journal Article
Evidence for a Common Mucosal Immunologic System I. Migration of B Immunoblasts Into Intestinal, Respiratory, and Genital Tissues
TL;DR: The origins of immunoglobulin-containing cells in intestinal, respiratory, mammary, and genital tissues were studied in CBA/J female mice by using an adoptive lymphocyte transfer method and data support the concept of a common mucosal immunologic system.