Journal ArticleDOI
LIF receptor signaling modulates neural stem cell renewal
M. Pitman,Ben Emery,Michele D. Binder,Michele D. Binder,S. Wang,Helmut Butzkueven,Helmut Butzkueven,Trevor J. Kilpatrick,Trevor J. Kilpatrick,Trevor J. Kilpatrick +9 more
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TLDR
Although LIFR signaling is not necessary for NSC self-renewal, it enhances both the clonogenicity and the expression of GFAP by these multipotential cells.About:
This article is published in Molecular and Cellular Neuroscience.The article was published on 2004-11-01. It has received 95 citations till now. The article focuses on the topics: Leukemia inhibitory factor & Neurosphere.read more
Citations
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Revisiting STAT3 signalling in cancer: new and unexpected biological functions
TL;DR: Well known for its role in tumour cell proliferation, survival, invasion and immunosuppression, JAK–STAT3 signalling also promotes cancer through inflammation, obesity, stem cells and the pre-metastatic niche.
Journal ArticleDOI
Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF-1–CXCR4 Axis
Magda Kucia,Ryan Reca,Katarzyna Miekus,Jens Wanzeck,Wojtek Wojakowski,Anna Janowska-Wieczorek,Janina Ratajczak,Mariusz Z. Ratajczak +7 more
TL;DR: It is suggested that strategies aimed at modulating the SDF‐1–CXCR4 axis could have important clinical applications both in regenerative medicine to deliver normal stem cells to the tissues/organs and in clinical hematology/oncology to inhibit metastasis of cancer stem cells.
Journal ArticleDOI
Cytokines and CNS development.
TL;DR: The extensive and diverse requirements for properly regulated cytokine signaling during normal nervous system development revealed by these studies sets the foundation for ongoing and future work aimed at understanding how cytokines induced normally and pathologically during critical stages of fetal development alter nervous system function and behavior later in life.
Journal ArticleDOI
Neural stem cells and neurospheres--re-evaluating the relationship.
TL;DR: Several shortcomings of the neurosphere assay related to its application and interpretation are highlighted that are believed to have led to a significant body of research whose conclusions may well be misleading.
Journal ArticleDOI
The neuropoietic cytokine family in development, plasticity, disease and injury
TL;DR: This work has shown that neuropoietic cytokines, well known for their role in the control of neuronal, glial and immune responses to injury or disease, have yet more functions, as key modulators of synaptic plasticity and of various behaviours.
References
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Journal ArticleDOI
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more
TL;DR: Cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.
Journal ArticleDOI
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
Austin Smith,John K. Heath,Deborah D. Donaldson,Gordon G. Wong,Jean-François Moreau,Mark Stahl,David J. Rogers +6 more
TL;DR: DIA and human interleukin DA/leukaemia inhibitory factor have been identified as related multifunctional regulatory factors with distinct biological activities in both early embryonic and haemopoetic stem cell systems.
Journal ArticleDOI
Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia.
TL;DR: This report shows that SVZ cells labeled in the brains of adult mice with [3H]thymidine differentiate directly into neurons and glia in explant cultures, and shows that 98% of the neurons that differentiate from the SVZ explants are derived from precursor cells that underwent their last division in vivo.
Journal ArticleDOI
Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.
TL;DR: A simple model in which transient exposure to extrinsic factors acting through known pathways initiates fate decisions by multipotential CNS stem cells is supported.
Journal ArticleDOI
Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway
Azad Bonni,Yi Sun,Mireya Nadal-Vicens,Ami Bhatt,David A. Frank,Irina Rozovsky,Neil Stahl,George D. Yancopoulos,Michael E. Greenberg +8 more
TL;DR: The findings suggest that cytokine activation of the JAK-STAT signaling pathway may be a mechanism by which cell fate is controlled during mammalian development.
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The Ciliary Neurotrophic Factor/Leukemia Inhibitory Factor/gp130 Receptor Complex Operates in the Maintenance of Mammalian Forebrain Neural Stem Cells
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more