Journal ArticleDOI
Long non-coding RNA Pvt1 modulates the pathological cardiac hypertrophy via miR-196b-mediated OSMR regulation.
TLDR
In this article, the effect of miR-196b suppression upon the B-raf was shown to be opposite to Pvt1 knockdown, which suggests that miR196b suppressing might significantly attenuate the effects of Pvt 1 knockdown.About:
This article is published in Cellular Signalling.The article was published on 2021-07-07. It has received 6 citations till now. The article focuses on the topics: Oncostatin M & Sudden death.read more
Citations
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Identification of a circulating microRNAs biomarker panel for non-invasive diagnosis of coronary artery disease: case–control study
Hoda Y Abdallah,Ranya Hassan,A. Fareed,Mai Abdelgawad,Sally Abdallah Mostafa,Eman A. Mohammed +5 more
TL;DR: In this paper , the authors investigated a panel of 14 miRNAs selected using bioinformatics databases and current literature searching for miRNUs involved in CAD using quantitative real-time PCR technique in 73 CAD patients compared to 73 controls.
Journal ArticleDOI
Exosomal hsa_circ_0017252 attenuates the development of gastric cancer via inhibiting macrophage M2 polarization
TL;DR: The data suggest that the overexpression of hsa_circ_0017252 suppresses GC malignancy by sponging miR-17-5p and attenuated GC progression by suppressing macrophage M2-like polarization.
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Long Non-Coding RNAs Might Regulate Phenotypic Switch of Vascular Smooth Muscle Cells Acting as ceRNA: Implications for In-Stent Restenosis
TL;DR: The PVT1 ceRNA axis appears to be an attractive target for in-stent restenosis diagnosis and treatment of vascular smooth muscle cells under stimuli resembling stent injury.
Journal ArticleDOI
Identification of novel biomarkers in septic cardiomyopathy via integrated bioinformatics analysis and experimental validation
TL;DR: It was demonstrated that STAT3, SOCS3, CCL2, IL1R2, JUNB, S100A9, OSMR, ZFP36, and HAMP might play important roles in SCM.
Journal ArticleDOI
Regulation mechanism and pathogenic role of lncRNA plasmacytoma variant translocation 1 (PVT1) in human diseases
TL;DR: In this paper , the authors summarize the recent progressions on the mechanisms underlying PVT1 regulated gene expression at different levels and discuss the interaction between lncRNA and protein, RNA and DNA, as well as the potential cancer therapy strategy by targeting these networks.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
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Long non-coding RNAs: A new frontier in the study of human diseases
TL;DR: The rapidly advancing field of lncRNAs is reviewed and the relationship between the dysregulation of l NCRNAs and human diseases is described, highlighting the specific roles of lNCRNAs in human diseases.
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Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.
TL;DR: The results suggest that in rats with ascending aortic banding the hypertrophic phenotype is associated with a selective reinduction of the fetal gene program, which persists even after the development of left ventricular failure.
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Oncostatin M Is a Major Mediator of Cardiomyocyte Dedifferentiation and Remodeling
Thomas Kubin,Jochen Pöling,Sawa Kostin,Praveen Gajawada,Stefan Hein,W. Rees,Astrid Wietelmann,Minoru Tanaka,Holger Lörchner,Silvia Schimanski,Marten Szibor,Henning Warnecke,Thomas Braun +12 more
TL;DR: It is demonstrated that oncostatin M (OSM) is a major mediator of cardiomyocyte dedifferentiation and remodeling during acute myocardial infarction (MI) and in chronic dilatedCardiomyopathy (DCM).
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A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling.
Leonardo Schirone,Maurizio Forte,Silvia Palmerio,Derek Yee,Cristina Nocella,Francesco Angelini,Francesca Pagano,Sonia Schiavon,Antonella Bordin,Albino Carrizzo,Carmine Vecchione,Valentina Valenti,Isotta Chimenti,Elena De Falco,Sebastiano Sciarretta,Giacomo Frati +15 more
TL;DR: A better understanding of cell signaling involved in cardiac remodeling may support the development of new therapeutic strategies towards the treatment of heart failure and reduction of cardiac complications.