Journal ArticleDOI
Long-term Course and Prognosis of Idiopathic Pulmonary Fibrosis in the New Millennium
Steven D. Nathan,Oksana A. Shlobin,Nargues Weir,Shahzad Ahmad,Julienne M. Kaldjob,Edwinia Battle,Michael J. Sheridan,Roland M. du Bois +7 more
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TLDR
The analysis supports the view that the value of statements can be realized in the subsequent demonstration of their impact on patient management, which might enable further refinements in a continuous, iterative rediscovery process.About:
This article is published in Chest.The article was published on 2011-07-01. It has received 287 citations till now. The article focuses on the topics: Idiopathic pulmonary fibrosis & Pulmonary function testing.read more
Citations
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Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study
Imre Noth,Yingze Zhang,Shwu Fan Ma,Carlos Flores,Mathew Barber,Yong Huang,Steven M. Broderick,Michael S. Wade,Pirro G. Hysi,Joseph Scuirba,Thomas J. Richards,Brenda Juan-Guardela,Rekha Vij,MeiLan K. Han,Fernando J. Martinez,Karl Kossen,Scott D. Seiwert,Jason D. Christie,Dan L. Nicolae,Naftali Kaminski,Joe G.N. Garcia +20 more
TL;DR: A three-stage genome-wide association study to identify additional common variants associated with susceptibility and ultimately mortality in Idiopathic pulmonary fibrosis and novel variants in TOLLIP and SPPL2C are associated with IPF susceptibility.
Journal ArticleDOI
A Placebo-Controlled Randomized Trial of Warfarin in Idiopathic Pulmonary Fibrosis
Imre Noth,Kevin J. Anstrom,Sara B. Calvert,Joao A. de Andrade,Kevin R. Flaherty,Craig S. Glazer,Robert J. Kaner,Mitchell A. Olman +7 more
TL;DR: Treatment with warfarin was associated with an increased risk of mortality in an IPF population who lacked other indications for anticoagulation and was recommended to stop after 145 of the planned 256 subjects were enrolled.
Journal ArticleDOI
Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease
Joshua J. Solomon,Jonathan H. Chung,Gregory P. Cosgrove,M. Kristen Demoruelle,Evans R. Fernandez-Perez,Aryeh Fischer,Stephen K. Frankel,Stephen B. Hobbs,Tristan J. Huie,Jill Ketzer,Amar Mannina,Amy L. Olson,Gloria Russell,Yutaka Tsuchiya,Zulma X. Yunt,Pearlanne T. Zelarney,Kevin K. Brown,Jeffrey J. Swigris +17 more
TL;DR: Data from this study suggest that in rheumatoid-arthritis associated interstitial lung disease, disease progression and survival differ between subgroups defined by HRCT pattern; however, when controlling for potentially influential variables, pulmonary physiology, but notHRCT pattern, independently predicts mortality.
Journal ArticleDOI
Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis
Steven D. Nathan,Carlo Albera,Williamson Z. Bradford,Ulrich Costabel,Ian Glaspole,Marilyn K. Glassberg,David Kardatzke,Monica Daigl,Klaus Uwe Kirchgaessler,Lisa Lancaster,David J. Lederer,Carlos Alberto de Castro Pereira,Jeffrey J. Swigris,Dominique Valeyre,Paul W. Noble +14 more
TL;DR: Several analytic approaches demonstrated that pirfenidone therapy is associated with a reduction in the relative risk of mortality compared with placebo over 120 weeks.
Journal ArticleDOI
A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis
Daniel C. Chambers,D. Enever,Nina Ilic,Lisa Sparks,Kylie Whitelaw,John Ayres,Stephanie T. Yerkovich,Dalia Khalil,Kerry Atkinson,Kerry Atkinson,Peter Hopkins +10 more
TL;DR: Mesenchymal stromal cells, a key component of the stem cell niche in bone marrow and possibly other organs including lung, have been shown to enhance epithelial repair and are effective in preclinical models of inflammation‐induced pulmonary fibrosis, but may be profibrotic in some circumstances.
References
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Journal ArticleDOI
An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-Based Guidelines for Diagnosis and Management
Ganesh Raghu,Harold R. Collard,Jim J. Egan,Fernando J. Martinez,Juergen Behr,Kevin K. Brown,Thomas V. Colby,Jean-François Cordier,Kevin R. Flaherty,Joseph A. Lasky,David A. Lynch,Jay H. Ryu,Jeffrey J. Swigris,Athol U. Wells,Julio Ancochea,Demosthenes Bouros,Carlos Roberto Ribeiro de Carvalho,Ulrich Costabel,Masahito Ebina,David M. Hansell,Takeshi Johkoh,Dong Soon Kim,Talmadge E. King,Yasuhiro Kondoh,Jeffrey L. Myers,Nestor L. Müller,Andrew G. Nicholson,Luca Richeldi,Moisés Selman,Rosalind F. Dudden,Barbara S. Griss,Shandra Protzko,Holger J. Schünemann +32 more
TL;DR: This document represents the current state of knowledge regarding idiopathic pulmonary fibrosis, and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course.
Journal ArticleDOI
Idiopathic pulmonary fibrosis : Diagnosis and treatment. International consensus statement
Jr King,Ulrich Costabel,Jean-François Cordier,G. A. DoPico,R. M. DuBois,David A. Lynch,Joseph P. Lynch,J.L. Myers,R. Panos,Ganesh Raghu,David A. Schwartz,C. M. Smith +11 more
TL;DR: Many acute and chronic lung disorders with variable degrees of pulmonary inflammation and fibrosis are collectively referred to as interstitial lung diseases (ILDs) or diffuse parenchymal lung diseases.
Journal ArticleDOI
Changes in the normal maximal expiratory flow-volume curve with growth and aging.
TL;DR: Improved prediction equations for each sex by age group for 5 spirometric and flow-volume variables are derived and "Normal" limits are proposed that take into consideration the between-subject variability and non-Gaussian distribution of the various measurements.
Journal ArticleDOI
Prognostic Significance of Histopathologic Subsets in Idiopathic Pulmonary Fibrosis
Julie A. Bjoraker,Jay H. Ryu,Mark K. Edwin,Jeffrey L. Myers,Henry D. Tazelaar,Darrell R. Schroeder,Kenneth P. Offord +6 more
TL;DR: Retrospective analysis of 104 patients with IPF who had open lung biopsy at Mayo Medical Center from 1976 to 1985 was performed to establish the overall survival rate, the spectrum of histopathological subgroups and their associated prognostic significance.
Journal ArticleDOI
International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation.
Jonathan B. Orens,Marc Estenne,Selim M. Arcasoy,John V. Conte,Paul A. Corris,Jim J. Egan,Thomas M. Egan,Shaf Keshavjee,Christiane Knoop,Robert M. Kotloff,Fernando J. Martinez,Steven D. Nathan,Scott M. Palmer,A. Patterson,Lianne G. Singer,Gregory I Snell,Sean M. Studer,Jean-Luc Vachiery,Allan R. Glanville +18 more
TL;DR: This update to the international guidelines is based primarily on a consensus of opinion rendered by experts in the field and should not be considered to be hard and fast rules.
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