Journal ArticleDOI
Long-term sedation in intensive care unit: a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam
Malcie Mesnil,Xavier Capdevila,S. Bringuier,Pierre-Olivier Trine,Yoan Falquet,Jonathan Charbit,J. P. Roustan,Gerald Chanques,Samir Jaber +8 more
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TLDR
Long-term inhaled sevoflurane sedation seems to be a safe and effective alternative to IV propofol or midazolam, and it decreases wake-up and extubation times, and post Extubation morphine consumption, and increases awakening quality.Abstract:
Purpose
To evaluate efficacy and adverse events related to inhaled sevoflurane for long-term sedation compared with standard intravenous (IV) sedation with propofol or midazolam.read more
Citations
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Journal ArticleDOI
Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
John W. Devlin,John W. Devlin,Yoanna Skrobik,Céline Gélinas,Dale M. Needham,Arjen J. C. Slooter,Pratik P. Pandharipande,Paula L. Watson,Gerald L. Weinhouse,Mark E. Nunnally,Bram Rochwerg,Michele C. Balas,Mark van den Boogaard,Karen J. Bosma,Karen J. Bosma,Nathaniel E. Brummel,Gerald Chanques,Linda Denehy,Xavier Drouot,Gilles L. Fraser,Jocelyn E. Harris,Aaron M. Joffe,Michelle E. Kho,John P. Kress,Julie A. Lanphere,Sharon McKinley,Karin J. Neufeld,Margaret A. Pisani,Jean François Payen,Brenda T. Pun,Kathleen Puntillo,Richard R. Riker,Bryce R.H. Robinson,Yahya Shehabi,Paul M. Szumita,Chris Winkelman,John Centofanti,Carrie Price,Sina Nikayin,Cheryl Misak,Pamela Flood,Ken Kiedrowski,Waleed Alhazzani +42 more
TL;DR: Substantial agreement was found among a large, interdisciplinary cohort of international experts regarding evidence supporting recommendations, and the remaining literature gaps in the assessment, prevention, and treatment of Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) in critically ill adults.
Journal ArticleDOI
Executive Summary : Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
John W. Devlin,John W. Devlin,Yoanna Skrobik,Céline Gélinas,Dale M. Needham,Arjen J. C. Slooter,Pratik P. Pandharipande,Paula L. Watson,Gerald L. Weinhouse,Mark E. Nunnally,Bram Rochwerg,Michele C. Balas,Mark van den Boogaard,Karen J. Bosma,Nathaniel E. Brummel,Gerald Chanques,Linda Denehy,Xavier Drouot,Gilles L. Fraser,Jocelyn E. Harris,Aaron M. Joffe,Michelle E. Kho,John P. Kress,Julie A. Lanphere,Sharon McKinley,Karin J. Neufeld,Margaret A. Pisani,Jean François Payen,Brenda T. Pun,Kathleen Puntillo,Richard R. Riker,Bryce R.H. Robinson,Yahya Shehabi,Paul M. Szumita,Chris Winkelman,John Centofanti,Carrie Price,Sina Nikayin,Cheryl Misak,Pamela Flood,Ken Kiedrowski,Waleed Alhazzani +41 more
TL;DR: Author(s): Devlin, John W; Skrobik, Yoanna; Gelinas, Celine; Needham, Dale M; Slooter, Arjen JC; Pandharipande, Pratik P; Watson, Paula L; Weinhouse, Gerald L; Nunnally, Mark E; Rochwerg, Bram; Balas, Michele C; van den Boogaard, Mark; Bosma, Karen J; Brummel, Nathaniel E.
Journal ArticleDOI
Sedation and Analgesia in the Mechanically Ventilated Patient
Shruti B. Patel,John P. Kress +1 more
TL;DR: Advances in the field of ICU sedation are reviewed to provide an up-to-date perspective on management of the mechanically ventilated ICU patient.
Journal ArticleDOI
Analgesia and sedation in patients with ARDS.
Gerald Chanques,Jean-Michel Constantin,John W. Devlin,E. Wesley Ely,Gilles L. Fraser,Céline Gélinas,Timothy D. Girard,Claude Guérin,Claude Guérin,Matthieu Jabaudon,Matthieu Jabaudon,Samir Jaber,Sangeeta Mehta,Thomas Langer,Michael J. Murray,Pratik P. Pandharipande,Bhakti K. Patel,Jean François Payen,Kathleen Puntillo,Bram Rochwerg,Yahya Shehabi,Yahya Shehabi,Thomas Strøm,Hanne T. Olsen,John P. Kress +24 more
TL;DR: An expert panel was convened to produce a “state-of-the-art” article to support clinicians in the optimal management of analgesia/sedation in mechanically ventilated adults with ARDS, including those with COVID-19.
Journal ArticleDOI
Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study.
Matthieu Jabaudon,Pierre Boucher,Etienne Imhoff,Russell Chabanne,Jean-Sébastien Faure,Laurence Roszyk,Sandrine Thibault,Raiko Blondonnet,Gael Clairefond,Renaud Guérin,Sébastien Perbet,Sophie Cayot,Thomas Godet,Bruno Pereira,Vincent Sapin,Jean-Etienne Bazin,Emmanuel Futier,Jean-Michel Constantin +17 more
TL;DR: In patients with ARDS, use of inhaled sevoflurane improved oxygenation and decreased levels of a marker of epithelial injury and of some inflammatory markers, compared with midazolam.
References
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Journal ArticleDOI
Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation
TL;DR: A randomized, controlled trial involving 128 adult patients who were receiving mechanical ventilation and continuous infusions of sedative drugs in a medical intensive care unit found that the intervention group increased the median duration of mechanical ventilation, as compared with 7.3 days in the control group.
Journal ArticleDOI
Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
E. Wesley Ely,Ayumi Shintani,Brenda Truman,Theodore Speroff,Sharon M. Gordon,Frank E. Harrell,Sharon K. Inouye,Gordon R. Bernard,Robert S. Dittus +8 more
TL;DR: Delirium was an independent predictor of higher 6-month mortality and longer hospital stay even after adjusting for relevant covariates including coma, sedatives, and analgesics in patients receiving mechanical ventilation.
Journal ArticleDOI
Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation.
Alan D. Brook,Thomas S. Ahrens,Robyn Schaiff,Donna Prentice,Glenda Sherman,William D. Shannon,Marin H. Kollef +6 more
TL;DR: The use of protocol-directed sedation can reduce the duration of mechanical ventilation, the intensive care unit and hospital lengths of stay, and the need for tracheostomy among critically ill patients with acute respiratory failure.
Journal ArticleDOI
Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study.
Jean François Payen,Gerald Chanques,Jean Mantz,Christiane Hercule,Igor Auriant,Jean Luc Leguillou,Michèle Binhas,Céline Genty,C. Rolland,J.-L. Bosson +9 more
TL;DR: In this paper, the authors conducted a patient-based survey of practices to fully describe the assessment and the management of pain and sedation of a large cohort of mechanically ventilated patients during their first week of intensive care unit (ICU) stay.
Journal ArticleDOI
Overestimation of Bispectral Index in Sedated Intensive Care Unit Patients Revealed by Administration of Muscle Relaxant
TL;DR: The authors conclude that clinicians who determine the amount of sedation in intensive care unit patients only from BIS monitoring may expose them to unnecessary oversedation.
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