Journal ArticleDOI
A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial
TLDR
No sedation of critically ill patients receiving mechanical ventilation is associated with an increase in days without ventilation, and a multicentre study is needed to establish whether this effect can be reproduced in other facilities.About:
This article is published in The Lancet.The article was published on 2010-02-06. It has received 708 citations till now. The article focuses on the topics: Sedation & Mechanical ventilation.read more
Citations
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Journal ArticleDOI
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.
R. P. Dellinger,Mitchell M. Levy,Andrew Rhodes,Djillali Annane,Herwig Gerlach,Steven M. Opal,Jonathan E. Sevransky,Charles L. Sprung,Ivor S. Douglas,Roman Jaeschke,Tiffany M. Osborn,Mark E. Nunnally,Konrad Reinhart,Ruth M. Kleinpell,Derek C. Angus,Clifford S. Deutschman,Flávia Ribeiro Machado,Gordon D. Rubenfeld,Steven A R Webb,Richard Beale,Jean Louis Vincent,Rui Moreno +21 more
TL;DR: An update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008 is provided.
Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
R. Phillip Dellinger,Mitchell M. Levy,Andrew Rhodes,Djillali Annane,Herwig Gerlach,Steven M. Opal,Jonathan E. Sevransky,Charles L. Sprung,Ivor S. Douglas,Roman Jaeschke,Tiffany M. Osborn,Mark E. Nunnally,Sean R. Townsend,Konrad Reinhart,Ruth M. Kleinpell,Derek C. Angus,Clifford S. Deutschman,Flávia Ribeiro Machado,Gordon D. Rubenfeld,Steven A R Webb,Richard Beale,Jean Louis Vincent,Rui Moreno +22 more
TL;DR: A consensus committee of 68 international experts representing 30 international organizations was convened in 2008 to provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock".
Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Andrew Rhodes,Laura Evans,Waleed Alhazzani,Mitchell M. Levy,Massimo Antonelli,Ricard Ferrer,Anand Kumar,Jonathan E. Sevransky,Charles L. Sprung,Mark E. Nunnally,Bram Rochwerg,Gordon D. Rubenfeld,Derek C. Angus,Djillali Annane,Richard Beale,Geoffrey J. Bellinghan,Gordon R. Bernard,Jean Daniel Chiche,Craig M. Coopersmith,Daniel De Backer,Craig French,Seitaro Fujishima,Herwig Gerlach,Jorge Hidalgo,Steven M. Hollenberg,Alan E. Jones,Dilip R. Karnad,Ruth M. Kleinpell,Younsuck Koh,Thiago Lisboa,Flávia Ribeiro Machado,John J. Marini,John C. Marshall,John E. Mazuski,Lauralyn McIntyre,Anthony S. McLean,Sangeeta Mehta,Rui Moreno,John Myburgh,Paolo Navalesi,Osamu Nishida,Tiffany M. Osborn,Anders Perner,Colleen M. Plunkett,Marco Ranieri,Christa A. Schorr,Maureen A. Seckel,Christopher W. Seymour,Lisa Shieh,Khalid A. Shukri,Steven Q. Simpson,Mervyn Singer,B. Taylor Thompson,Sean R. Townsend,Thomas Van der Poll,Jean Louis Vincent,W. Joost Wiersinga,Janice L. Zimmerman,R. Phillip Dellinger +58 more
TL;DR: Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Journal ArticleDOI
Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit
Juliana Barr,Gilles L. Fraser,Kathleen Puntillo,E. Wesley Ely,Céline Gélinas,Joseph F. Dasta,Judy E. Davidson,John W. Devlin,John P. Kress,Aaron M. Joffe,Douglas B. Coursin,Daniel Herr,Avery Tung,Bryce R.H. Robinson,Dorrie K. Fontaine,Michael A. E. Ramsay,Richard R. Riker,Curtis N. Sessler,Brenda T. Pun,Yoanna Skrobik,Roman Jaeschke +20 more
TL;DR: These guidelines provide a roadmap for developing integrated, evidence-based, and patient-centered protocols for preventing and treating pain, agitation, and delirium in critically ill patients.
Journal ArticleDOI
Severe sepsis and septic shock
Derek C. Angus,Tom van der Poll +1 more
TL;DR: A review of the basis, diagnosis, and current treatment of Sepsis in patients with this disorder is examined.
References
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Journal ArticleDOI
Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation
TL;DR: A randomized, controlled trial involving 128 adult patients who were receiving mechanical ventilation and continuous infusions of sedative drugs in a medical intensive care unit found that the intervention group increased the median duration of mechanical ventilation, as compared with 7.3 days in the control group.
Journal ArticleDOI
Controlled sedation with alphaxalone-alphadolone
TL;DR: Alphaxalone-alphadolone (Althesin), diluted and administered as a controlled infusion, was used as a sedative for 30 patients in an intensive therapy unit and provided “light sleep,” allowed rapid variation in the level of sedation, and enabled repeated assessment of the central nervous system.
Journal ArticleDOI
Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU).
Eugene Wesley Ely,Sharon K. Inouye,Gordon R. Bernard,Sharon M. Gordon,Joseph Francis,L. May,Brenda Truman,Theodore Speroff,Shiva Gautam,Richard Margolin,Robert P. Hart,Robert S. Dittus +11 more
TL;DR: The CAM-ICU appears to be rapid, valid, and reliable for diagnosing delirium in the ICU setting and may be a useful instrument for both clinical and research purposes.
Journal ArticleDOI
Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial.
William D. Schweickert,Mark C. Pohlman,Anne S. Pohlman,Celerina Nigos,Amy J. Pawlik,Cheryl L. Esbrook,Linda Spears,Megan E. Miller,Mietka Franczyk,Deanna Deprizio,Gregory A. Schmidt,Amy Bowman,Rhonda Barr,Kathryn E. McCallister,Jesse B. Hall,John P. Kress +15 more
TL;DR: A strategy for whole-body rehabilitation-consisting of interruption of sedation and physical and occupational therapy in the earliest days of critical illness-was safe and well tolerated, and resulted in better functional outcomes at hospital discharge, a shorter duration of delirium, and more ventilator-free days compared with standard care.
Journal ArticleDOI
Evaluation of Delirium in Critically Ill Patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
Eugene Wesley Ely,Richard Margolin,Joseph Francis,Lisa May,Brenda Truman,Robert S. Dittus,Theodore Speroff,Shiva Gautam,Gordon R. Bernard,Sharon K. Inouye +9 more
TL;DR: The CAM-ICU demonstrated excellent reliability and validity when used by nurses and physicians to identify delirium in intensive care unit patients and may be a useful instrument for both clinical and research purposes to monitor deliria in this challenging patient population.
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Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
Timothy D. Girard,John P. Kress,Barry D. Fuchs,Jason W. W. Thomason,William D. Schweickert,Brenda T. Pun,Darren B. Taichman,Jan Dunn,Anne S. Pohlman,Paul Kinniry,James C. Jackson,Angelo E. Canonico,Richard W. Light,Ayumi Shintani,Jennifer L. Thompson,Sharon M. Gordon,Sharon M. Gordon,Jesse B. Hall,Robert S. Dittus,Robert S. Dittus,Gordon R. Bernard,E. Wesley Ely,E. Wesley Ely +22 more
Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit
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