Journal ArticleDOI
Longitudinal organization of the anterior neural plate and neural tube
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TLDR
In this paper, the authors describe studies of the expression of several genes in the mouse between 7.5 and 10.5 days post coitum (dpc) that provide evidence for the trajectory of the anterior-posterior axis and the longitudinal organization of the CNS, and demonstrate that the earliest longitudinal axon pathways of the forebrain are spatially correlated with the longitudinal domain defined by Nkx-2.2.Abstract:
Over the last century, several morphological models of forebrain organization have been proposed that hypothesize alternative topological solutions for the relationships of the histogenic primordia. Central to all of these models are their definitions of the longitudinal axis and the longitudinal organization of the neural plate and neural tube. To understand the longitudinal organization of the anterior brain, we have sought to identify molecular properties that are continuous along the entire longitudinal axis of the embryonic CNS. In this essay, we describe studies of the expression of several genes in the mouse between 7.5 (presomite stage) and 10.5 days post coitum (dpc) that provide evidence for the trajectory of the anterior-posterior axis and the longitudinal organization of the anterior CNS. Specifically, we report that the expression of noggin, sonic hedgehog and Nkx-2.2 define longitudinal columns of cells that are present along the entire CNS axis. Within the forebrain, the expression of these genes, as well as that of Nkx-2.1 and BF-1, are in distinct longitudinal regions in the neural plate and tube. We demonstrate that the earliest longitudinal axon pathways of the forebrain are spatially correlated with the longitudinal domain defined by Nkx-2.2. Finally, expression of the former genes, and Otx-1 and Emx-2, suggests that the cephalic neural plate is organized into molecularly distinct domains delimited by longitudinal and transverse borders; these results provide a foundation for defining the mechanisms that pattern the neural plate.read more
Citations
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Systematic review of levodopa dose equivalency reporting in Parkinson's disease
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Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
TL;DR: The PATCHED (PTC) gene encodes a Sonic hedgehog (Shh) receptor and a tumor suppressor protein that is defective in basal cell nevus syndrome (BCNS).
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Patterning the Vertebrate Neuraxis
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TL;DR: Segmentation and long-range signaling from organizing centers are prominent among the emerging principles governing regional pattern.
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Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling
Johan Ericson,P. Rashbass,Andreas Schedl,Susan Brenner-Morton,Atsushi Kawakami,Veronica van Heyningen,Thomas M. Jessell,James Briscoe +7 more
TL;DR: P Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.
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Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
David Lyden,Alison Z. Young,David Zagzag,Wei Yan,William L. Gerald,Richard J. O'Reilly,Bernhard L. Bader,Richard O. Hynes,Yuan Zhuang,Katia Manova,Robert Benezra +10 more
TL;DR: Targeted disruption of the dominant negative helix–loop–helix proteins Id1 and Id3 in mice results in premature withdrawal of neuroblasts from the cell cycle and expression of neural-specific differentiation markers, which are required to maintain the timing of neuronal differentiation in the embryo and invasiveness of the vasculature.
References
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Book
Brain Maps: Structure of the Rat Brain
TL;DR: This atlas describes the development of the rat Brain through Cytoarchitecture, followed by a detailed description of Nervous System Development, and annotated Nomenclature Tables (tables and annotations in parallel), covering basic cell groups and Gross Anatomical Features of the Rat CNS.
Journal ArticleDOI
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
Yann Echelard,Douglas J. Epstein,Benoit St-Jacques,Liya Shen,Jym Mohler,Jill A. McMahon,Andrew P. McMahon +6 more
TL;DR: Three members of a mouse gene family related to the Drosophila segment polarity gene, hedgehog (hh), are identified and it is suggested that Shh may play a role in the normal inductive interactions that pattern the ventral CNS.
Journal ArticleDOI
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
TL;DR: The existence of an hh-related gene family in the zebrafish, Brachydanio rerio, that is expressed in the notochord, floor plate, and posterior fin mesoderm, tissues associated with polarizing activities in various vertebrate embryos is described.
Journal ArticleDOI
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
T N Tsuchida,Monica Ensini,S.B. Morton,Mark Baldassare,Thomas Edlund,Thomas M. Jessell,Samuel L. Pfaff +6 more
TL;DR: The results suggest that LIM homeobox genes contribute to the generation of motor neuron diversity and may confer subclasses of motor neurons with the ability to select specific axon pathways, thereby initiating the topographic organization of motor projections.
Journal ArticleDOI
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
Henk Roelink,Jeffery A. Porter,C Chiang,Y Tanabe,D.T Chang,Philip A. Beachy,Thomas M. Jessell +6 more
TL;DR: The results suggest that the induction of floor plate cells and motor neurons by the notochord in vivo is mediated by exposure of neural plate cells to different concentrations of the amino-terminal product of SHH autoproteolytic cleavage.