Journal ArticleDOI
Magnetofluorescent Carbon Dots Derived from Crab Shell for Targeted Dual-Modality Bioimaging and Drug Delivery
Yueh-Yun Yao,Gangaraju Gedda,Wubshet Mekonnen Girma,Chia-Liang Yen,Yong-Chien Ling,Jia-Yaw Chang +5 more
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TLDR
A one-pot microwave-assisted pyrolysis method for fabrication of magnetofluorescent carbon quantum dots (MFCQDs) using a combination of waste crab shell and three different transition-metal ions showed potential for development as diagnostic probes or theranostic agents.Abstract:
We propose a one-pot microwave-assisted pyrolysis method for fabrication of magnetofluorescent carbon quantum dots (MFCQDs), using a combination of waste crab shell and three different transition-metal ions, Gd3+, Mn2+, and Eu3+, referred to as Gd@CQDs, Mn@CQDs, and Eu@CQDs, respectively. Chitin from waste crab shell acted not only as a carbon source but also as a chelating ligand to form complexes with transition-metal ions. Gd@CQDs exhibited a high r1 relaxivity of 4.78 mM–1·s–1 and a low r2/r1 ratio of 1.33, suggesting that they show excellent potential as a T1 contrast agent. Mn@CQDs and Eu@CQDs showed high r2 relaxivity values of 140.7 and 28.32 mM–1·s–1, respectively, suggesting their potential for use as T2 contrast agents. Further conjugation of Gd@CQDs with folic acid (FA) enabled specific targeting to folate receptor-positive HeLa cells, as confirmed via in vitro magnetic resonance and fluorescence imaging. Doxorubicin (DOX) was selected as a model drug for conjugation with FA-Gd@CQDs. The as-pr...read more
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A Magnetofluorescent Carbon Dot Assembly as an Acidic H 2 O 2 -Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy
Qingyan Jia,Jiechao Ge,Weimin Liu,Xiuli Zheng,Shiqing Chen,Yongmei Wen,Hongyan Zhang,Pengfei Wang +7 more
TL;DR: The collective properties of the Mn‐CD assembly enable it to be utilized as an acidic H2O2‐driven oxygenerator to increase the oxygen concentration in hypoxic solid tumors for simultaneous bimodal FL/MR imaging and enhanced PDT.
Journal ArticleDOI
Sustainable carbon-dots: recent advances in green carbon dots for sensing and bioimaging
TL;DR: This study reviews the journey of green c-dots by means of green sources of synthesis and their applications, with the major focus on various sensors and bioimaging probes.
Journal ArticleDOI
A review on nanostructured carbon quantum dots and their applications in biotechnology, sensors, and chemiluminescence.
TL;DR: CQDs, their structure, and PL characteristics are introduced and recent advances of the application of CQDs in biotechnology, sensors, and CL is comprehensively discussed.
Journal ArticleDOI
Carbon quantum dots and their biomedical and therapeutic applications: a review
TL;DR: The nano carbon quantum dots (CQDs) have received increasing attention due to their properties such as small size, fluorescence emission, chemical stability, water solubility, easy synthesis, and the possibility of functionalization as discussed by the authors.
Journal ArticleDOI
Carbon-based nanomaterials as an emerging platform for theranostics
TL;DR: Carbon-based nanomaterials emerge as promising platforms for theranostic applications in disease treatment and tissue repair.
References
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Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications
TL;DR: A. Relaxivity 2331 E. Outerand Second-Sphere relaxivity 2334 F. Methods of Improving Relaxivity 2336 V. Macromolecular Conjugates 2336.
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Carbon quantum dots and their applications
TL;DR: The progress in the research and development of CQDs is reviewed with an emphasis on their synthesis, functionalization and technical applications along with some discussion on challenges and perspectives in this exciting and promising field.
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Carbon-Based Dots Co-doped with Nitrogen and Sulfur for High Quantum Yield and Excitation-Independent Emission†
Yongqiang Dong,Hongchang Pang,Hongbin Yang,Chunxian Guo,Jingwei Shao,Yuwu Chi,Chang Ming Li,Chang Ming Li,Ting Yu +8 more
TL;DR: A new type and high density of surface state of GQDs arises, leading to high yields (more than 70 %) and excitation-independent emission and FLQY = fluorescence quantum yield.
Journal ArticleDOI
Carbon quantum dots: synthesis, properties and applications
Youfu Wang,Aiguo Hu +1 more
TL;DR: Carbon quantum dots (CQDs, C-dots or CDs) have found wide use in more and more fields during the last few years as discussed by the authors, focusing on their synthetic methods, size control, modification strategies, photoelectric properties, luminescent mechanism, and applications in biomedicine, optronics, catalysis and sensor issues.
Journal ArticleDOI
Full-Color Light-Emitting Carbon Dots with a Surface-State-Controlled Luminescence Mechanism.
TL;DR: Carbon dots with tunable photoluminescence (PL) and a quantum yield of up to 35% in water were hydrothermally synthesized in one pot and separated via silica column chromatography, and these separated CDs emitted bright and stable luminescence in gradient colors under a single-wavelength UV light.