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Mechanisms of Muscle Injury, Repair, and Regeneration
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TLDR
The process of muscle injury, repair and regeneration that occurs in muscular dystrophy is used as an example of chronic muscle injury to highlight similarities and differences between the injury and repair processes that occur in acutely and chronically injured muscle.Abstract:
Skeletal muscle continuously adapts to changes in its mechanical environment through modifications in gene expression and protein stability that affect its physiological function and mass. However, mechanical stresses commonly exceed the parameters that induce adaptations, producing instead acute injury. Furthermore, the relatively superficial location of many muscles in the body leaves them further vulnerable to acute injuries by exposure to extreme temperatures, contusions, lacerations or toxins. In this article, the molecular, cellular, and mechanical factors that underlie muscle injury and the capacity of muscle to repair and regenerate are presented. Evidence shows that muscle injuries that are caused by eccentric contractions result from direct mechanical damage to myofibrils. However, muscle pathology following other acute injuries is largely attributable to damage to the muscle cell membrane. Many feaures in the injury-repair-regeneration cascade relate to the unregulated influx of calcium through membrane lesions, including: (i) activation of proteases and hydrolases that contribute muscle damage, (ii) activation of enzymes that drive the production of mitogens and motogens for muscle and immune cells involved in injury and repair, and (iii) enabling protein-protein interactions that promote membrane repair. Evidence is also presented to show that the myogenic program that is activated by acute muscle injury and the inflammatory process that follows are highly coordinated, with myeloid cells playing a central role in modulating repair and regeneration. The early-invading, proinflammatory M1 macrophages remove debris caused by injury and express Th1 cytokines that play key roles in regulating the proliferation, migration, and differentiation of satellite cells. The subsequent invasion by anti-inflammatory, M2 macrophages promotes tissue repair and attenuates inflammation. Although this system provides an effective mechanism for muscle repair and regeneration following acute injury, it is dysregulated in chronic injuries. In this article, the process of muscle injury, repair and regeneration that occurs in muscular dystrophy is used as an example of chronic muscle injury, to highlight similarities and differences between the injury and repair processes that occur in acutely and chronically injured muscle.read more
Citations
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References
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Journal ArticleDOI
Expression of truncated utrophin leads to major functional improvements in dystrophin-deficient muscles of mice.
Nicolas Deconinck,Jonathon M. Tinsley,F. De Backer,R Fisher,David Kahn,S Phelps,Kay E. Davies,Jean-Marie Gillis +7 more
TL;DR: It is demonstrated that trc-utrophin expression leads to major improvements of the mechanical performance of muscle (that is, force development, mechanical resistance to forced lengthenings and maximal spontaneous activity) and of the maintenance of the intracellular calcium homeostasis.
Journal ArticleDOI
Effect of resistance exercise on free radical-production
TL;DR: It is indicated that high intensity resistance exercise increases free radical production and that vitamin E supplementation may decrease muscle membrane disruption.
Journal ArticleDOI
TNF-α is a mitogen in skeletal muscle
TL;DR: The objective of the current study was to determine whether TNF-α modulates satellite cell proliferation, and to investigate the role of TNF in muscle repair.
Journal Article
Deposition of the terminal C5b-9 complement complex in infarcted areas of human myocardium.
TL;DR: It is suggested that initial ischemia may cause loss of the ability of the heart muscle cells to regulate complement turnover at the membrane level, and resulting deposition of C5b-9 on the cell membranes may contribute to functional disturbance and irreversible damage of myocardial cells during the infarction process.
Journal ArticleDOI
Chemotaxis of skeletal muscle satellite cells
TL;DR: It is proposed that the proliferation and migration of satellite cells during regeneration is regulated by overlapping gradients of several effector molecules released at the site of muscle injury.