Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives
Reads0
Chats0
TLDR
By far the most widespread mechanism of resistance to AGs is the inactivation of these antibiotics by AG-modifying enzymes, and an overview of these mechanisms is provided.Abstract:
Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-positive infections and, importantly, multidrug-resistant tuberculosis. Among various bacterial species, resistance to AGs arises through a variety of intrinsic and acquired mechanisms. The bacterial cell wall serves as a natural barrier for small molecules such as AGs and may be further fortified via acquired mutations. Efflux pumps work to expel AGs from bacterial cells, and modifications here too may cause further resistance to AGs. Mutations in the ribosomal target of AGs, while rare, also contribute to resistance. Of growing clinical prominence is resistance caused by ribosome methyltransferases. By far the most widespread mechanism of resistance to AGs is the inactivation of these antibiotics by AG-modifying enzymes. We provide here an overview of these mechanisms by which bacteria become resistant to AGs and discuss their prevalence and potential for clinical relevance.read more
Citations
More filters
Journal Article
High Genomic Diversity of Multi-Drug Resistant Wastewater
Norhan Mahfouz,Serena Caucci,Eric Achatz,Torsten Semmler,Sebastian Guenther,Thomas U. Berendonk,Michael Schroeder +6 more
TL;DR: The genomic diversity of the indicator Escherichia coli in a German wastewater treatment plant is analysed and it is found that while treatment plants reduce the amount of bacteria released into the environment, they do not reduce the potential for antibiotic resistance of these bacteria.
Journal ArticleDOI
Graphene oxide and carbon dots as broad-spectrum antimicrobial agents – a minireview
Anisha Anand,Binesh Unnikrishnan,Shih-Chun Wei,C. Perry Chou,Li-Zhi Zhang,Chih-Ching Huang,Chih-Ching Huang +6 more
TL;DR: Carbon-based materials, especially graphene oxide (GO) and carbon dots (C-Dots), are promising candidates for future applications against multidrug-resistant bacteria based on their strong capacity in disruption of microbial membranes.
Journal ArticleDOI
Antibiotics, Resistome and Resistance Mechanisms: A Bacterial Perspective.
Insha Sultan,Safikur Rahman,Arif Tasleem Jan,Mohammad Tahir Siddiqui,Aftab Hossain Mondal,Qazi Mohd. Rizwanul Haq +5 more
TL;DR: Proficiency of bacteria to obtain resistance genes generated an unpleasant situation; a grave, but a lot unacknowledged, feature of resistance gene transfer.
Journal ArticleDOI
Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.
TL;DR: The modes of action of many ribosome-targeting antibiotics are described, the major resistance mechanisms developed by pathogenic bacteria are highlighted, and recent advances in structure-assisted design of new molecules are discussed.
Journal ArticleDOI
Antibiotic Resistance and the MRSA Problem
TL;DR: Besides development of new small molecules affecting cell viability, alternative approaches including anti-virulence and bacteriophage therapeutics are being investigated and may become important tools to combat staphylococcal infections in the future.
References
More filters
Journal ArticleDOI
Activity of plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece.
Irene Galani,Maria Souli,George L. Daikos,Zoi Chrysouli,Garyphalia Poulakou,Mina Psichogiou,Theofano Panagea,Athina Argyropoulou,Ioanna Stefanou,George Plakias,Helen Giamarellou,George Petrikkos +11 more
TL;DR: ACHN-490 retained activity against all isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp.
Journal ArticleDOI
Lack of antimicrobial bactericidal activity in Mycobacterium abscessus
Florian P. Maurer,Vera L. Bruderer,Claudia Ritter,Claudio Castelberg,Guido V. Bloemberg,Erik C. Böttger +5 more
TL;DR: The lack of bactericidal antibiotics in currently recommended treatment regimens provides a reasonable explanation for the poor therapeutic outcome in M. abscessus infection and suggests that chromosomally encoded drug-modifying enzymes play an important role in the lack of aminoglycoside bactericidal activity against rapidly growing mycobacteria.
Journal ArticleDOI
Complete Sequence of a Novel 178-Kilobase Plasmid Carrying blaNDM-1 in a Providencia stuartii Strain Isolated in Afghanistan
Patrick Mc Gann,Jun Hang,Robert J. Clifford,Yu Yang,Yoon I. Kwak,Robert A. Kuschner,Emil Lesho,Paige E. Waterman +7 more
TL;DR: The finding of this gene in an intrinsically colistin-resistant species such as Providencia stuartii is especially worrisome, as it renders the organism resistant to nearly every available antibiotic.
Journal ArticleDOI
Carbapenem-Resistant Klebsiella pneumoniae Strains Exhibit Diversity in Aminoglycoside-Modifying Enzymes, Which Exert Differing Effects on Plazomicin and Other Agents
Reem Almaghrabi,Cornelius J. Clancy,Cornelius J. Clancy,Yohei Doi,Binghua Hao,Liang Chen,Ryan K. Shields,Ellen G. Press,Nicole M. Iovine,Bethany M. Townsend,Marilyn M. Wagener,Barry N. Kreiswirth,M. Hong Nguyen +12 more
TL;DR: In conclusion, carbapenem-resistant K. pneumoniae strains (including ST258 clones) exhibit highly diverse antimicrobial resistance genotypes and phenotypes and plazomicin may offer a treatment option against strains resistant to other aminoglycosides.
Journal ArticleDOI
Membrane Proteases and Aminoglycoside Antibiotic Resistance
TL;DR: It is proposed that the network of proteases provides robust protection from aminoglycosides and other substances through the elimination of membrane-disruptive mistranslation products.