Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives
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TLDR
By far the most widespread mechanism of resistance to AGs is the inactivation of these antibiotics by AG-modifying enzymes, and an overview of these mechanisms is provided.Abstract:
Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-positive infections and, importantly, multidrug-resistant tuberculosis. Among various bacterial species, resistance to AGs arises through a variety of intrinsic and acquired mechanisms. The bacterial cell wall serves as a natural barrier for small molecules such as AGs and may be further fortified via acquired mutations. Efflux pumps work to expel AGs from bacterial cells, and modifications here too may cause further resistance to AGs. Mutations in the ribosomal target of AGs, while rare, also contribute to resistance. Of growing clinical prominence is resistance caused by ribosome methyltransferases. By far the most widespread mechanism of resistance to AGs is the inactivation of these antibiotics by AG-modifying enzymes. We provide here an overview of these mechanisms by which bacteria become resistant to AGs and discuss their prevalence and potential for clinical relevance.read more
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References
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Journal ArticleDOI
Extracellular zinc induces phosphoethanolamine addition to Pseudomonas aeruginosa lipid A via the ColRS two-component system
TL;DR: The identified key pEtN transferase which is named EptAPa and characterized its strict activity on only one position of lipid A, contrasting from previously studied EptA enzymes, and it is shown that transcription of ept APa is regulated by zinc via the ColRS two‐component system instead of the PmrAB system responsible for eptA regulation in E. coli and Salmonella enterica.
Journal ArticleDOI
Emergence of OXA-carbapenemase- and 16S rRNA methylase-producing international clones of Acinetobacter baumannii in Norway.
Nabil Karah,Bjørg Haldorsen,Nils Olav Hermansen,Yngvar Tveten,Eivind Ragnhildstveit,Dag Harald Skutlaberg,Ståle Tofteland,Arnfinn Sundsfjord,Arnfinn Sundsfjord,Ørjan Samuelsen +9 more
TL;DR: Investigation of the molecular epidemiology and antibiotic-resistance characteristics of 11 carbapenem-resistant clinical isolates of Acinetobacter baumannii obtained in Norway found all the isolates were linked with recent hospitalization outside Norway and were related to the worldwide distribution of international clones I and II, and the emergence of novel international clones.
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NDM-8 Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli Strain Isolated in Nepal
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TL;DR: A novel metallo-β-lactamase, NDM-8, was identified in a multidrug-resistant Escherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal.