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Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem

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TLDR
Underappreciated features include the wide variety of extraintestinal infections E. coli can cause, the high incidence and associated morbidity, mortality, and costs of these diverse clinical syndromes, and increasing antimicrobial resistance.
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This article is published in Microbes and Infection.The article was published on 2003-04-01. It has received 701 citations till now. The article focuses on the topics: Extraintestinal Pathogenic Escherichia coli.

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Foodborne Illness Acquired in the United States

TL;DR: The strength of the correlation between norovirus outbreaks and survey results suggests that the population survey is sensitive to norov virus activity and that Norovirus may account for much of what is considered to be unspecified.
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The population genetics of commensal Escherichia coli.

TL;DR: The population structure of commensal E. coli is described, the factors involved in the spread of different strains, how the bacteria can adapt to different niches and how a Commensal lifestyle can evolve into a pathogenic one are described.
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Escherichia coli ST131, an Intriguing Clonal Group

TL;DR: Six years after the first description of E. coli ST131, this review outlines the principal traits of ST131 clonal group isolates, based on the growing body of published data, and highlights what is currently known and what the authors need to find out to provide public health authorities with better information to help combat ST131.
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Escherichia coli Sequence Type ST131 as the Major Cause of Serious Multidrug-Resistant E. coli Infections in the United States

TL;DR: In this paper, the CTX-M-15 extended-spectrum beta-lactamase-associated Escherichia coli sequence type ST131 (O25:H4) has emerged internationally as a multidrug-resistant pathogen but has received little attention in the United States.
References
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Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.

TL;DR: Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction, and is especially common in the elderly and is likely to increase substantially as the U.S. population ages.
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Efficacy and safety of recombinant human activated protein C for severe sepsis.

TL;DR: This phase 3 trial assessed whether treatment with drotrecogin alfa activated reduced the rate of death from any cause among patients with severe sepsis.
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Diarrheagenic Escherichia coli

TL;DR: The current level of understanding of the pathogenesis of the diarrheagenic E. coli strains is discussed and how their pathogenic schemes underlie the clinical manifestations, diagnostic approach, and epidemiologic investigation of these important pathogens are described.
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The world health report 2000 - Health systems: improving performance

TL;DR: The chief virtue of the WHO report lies in the challenges it poses for its critics within the health services research community, and it is fair to query whether, on balance, so precarious an undertaking does more good than harm.
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The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs.

TL;DR: In the 1990s, patients who develop SSI have longer and costlier hospitalizations than patients who do not develop such infections, and programs that reduce the incidence of SSI can substantially decrease morbidity and mortality and reduce the economic burden for patients and hospitals.
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