Journal ArticleDOI
Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption.
TLDR
Countermeasures to the effects of ALAN, such as melatonin, bright light, or psychotropic drugs, have been proposed as a means to combat circadian clock disruption and improve adaptation to shift and night work.About:
This article is published in Life Sciences.The article was published on 2017-03-15. It has received 405 citations till now. The article focuses on the topics: Shift work & Dark therapy.read more
Citations
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Journal ArticleDOI
Chronic inflammation in the etiology of disease across the life span
David Furman,Judith Campisi,Judith Campisi,Eric Verdin,Pedro Carrera-Bastos,Sasha Targ,Claudio Franceschi,Luigi Ferrucci,Derek W. Gilroy,Alessio Fasano,Gary W. Miller,Andrew H. Miller,Alberto Mantovani,Alberto Mantovani,Alberto Mantovani,Cornelia M. Weyand,Nir Barzilai,Jorge Goronzy,Thomas A. Rando,Thomas A. Rando,Rita B. Effros,Alejandro Lucia,Nicole Kleinstreuer,George M. Slavich +23 more
TL;DR: The multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress are described.
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Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence.
TL;DR: Emerging randomised controlled trials of physical activity and dietary factors and mechanistic studies of immunity, inflammation, extracellular matrix mechanics, epigenetic or transcriptional regulation, protein translation, circadian disruption, and interactions of the multibiome with lifestyle factors will be crucial to advance this field.
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Systematic review of light exposure impact on human circadian rhythm
TL;DR: A systematic literature survey was conducted by searching for two concepts: light and circadian rhythm, and it was indicated that a two-hour exposure to blue light in the evening suppresses melatonin, the maximum melatonin-suppressing effect being achieved at the shortest wavelengths.
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Melatonin and Hippo Pathway: Is There Existing Cross-Talk?
TL;DR: The structure and functions of melatonin and its receptors are described, and both molecular and epidemiological evidence on melatonin anticancer effects are discussed, to shed light on potential cross-talk between melatonin signaling and the Hippo signaling pathway.
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Disruption of adolescents' circadian clock: The vicious circle of media use, exposure to light at night, sleep loss and risk behaviors.
TL;DR: The sensitivity of adolescents to light including LEDs with the effects on the circadian system, the crosstalk between the clock and the pineal gland, the role of melatonin, and the behavior of some adolescents(media use, alcohol consumption, binge drinking, smoking habits, stimulant use…).
References
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Phototransduction by retinal ganglion cells that set the circadian clock.
TL;DR: It is shown that retinal ganglion cells innervating the SCN are intrinsically photosensitive, and depolarized in response to light even when all synaptic input from rods and cones was blocked.
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Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite.
TL;DR: In this study, 12 young, healthy, normal-weight men exhibited reductions in the satiety hormone leptin, increases in the hunger hormone ghrelin, and increases in hunger after 2 nights of only 4 hours of sleep compared with after two nights of 10 hours ofSleep, suggesting inadequate sleep seems to influence the hormones that regulate satiety and hunger.
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Rotating Night Shifts and Risk of Breast Cancer in Women Participating in the Nurses' Health Study
Eva S. Schernhammer,Francine Laden,Frank E. Speizer,Walter C. Willett,David J. Hunter,Ichiro Kawachi,Graham A. Colditz +6 more
TL;DR: Women who work on rotating night shifts with at least three nights per month, in addition to days and evenings in that month, appear to have a moderately increased risk of breast cancer after extended periods of working rotating night shift.
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Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression
Jamie M. Zeitzer,Jamie M. Zeitzer,Derk-Jan Dijk,Richard E. Kronauer,Richard E. Kronauer,Richard E. Kronauer,Emery N. Brown,Emery N. Brown,Emery N. Brown,Charles A. Czeisler,Charles A. Czeisler,Charles A. Czeisler +11 more
TL;DR: It is demonstrated that humans are highly responsive to the phase‐delaying effects of light during the early biological night and that both the phase resetting response to light and the acute suppressive effect of light on plasma melatonin follow a logistic dose‐response curve, as do many circadian responses to light in mammals.
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Melatonin as a natural ally against oxidative stress: a physicochemical examination
TL;DR: In this article, a review summarizes the current progress in understanding the physicochemical insights related to the free radical-scavenging activity of melatonin and concludes that melatonin efficiently protects against oxidative stress by a variety of mechanisms.