Journal ArticleDOI
Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes.
Anju Chadha,K. Madhava Madyastha +1 more
TLDR
Both NADH- and NADPH-cytochrome c reductase activities were not significantly changed during the six days of treatment and Oral administration of these two terpenoids did not affect any of the lung-microsomal parameters measured.Abstract:
1. Metabolites isolated from the urine of rats after oral administration of geraniol (I) were: geranic acid (II), 3-hydroxy-citronellic acid (III), 8-hydroxy-geraniol (IV), 8-carboxy-geraniol (V) and Hildebrandt acid (VI).
2. Metabolites isolated from urine of rats after oral administration of linalool (VII) were 8-hydroxy-linalool (VIII) and 8-carboxy-linalool (IX).
3. After three days of feeding rats with either geraniol or linalool, liver-microsomal cytochrome P-450 was increased. Both NADH- and NADPH-cytochrome c reductase activities were not significantly changed during the six days of treatment.
4. Oral administration of these two terpenoids did not affect any of the lung-microsomal parameters measured.read more
Citations
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Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission, Flavouring Group Evaluation 22: Ring-substituted phenolic substances from chemical groups 21 and 25: Question No EFSA-Q-2003-165
John Christian Larsen,Karin Kristiane Nørby,Trine Klein Reffstrup,Vibe Meister Beltoft,Henrik Lauritz Frandsen +4 more
TL;DR: The Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (the Panel) is asked to advise the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States as mentioned in this paper.
Journal ArticleDOI
Inhibition of Pancreatic Cancer Growth by the Dietary Isoprenoids Farnesol and Geraniol
TL;DR: Farnesol, geraniol, and perillyl alcohol suppress pancreatic tumor growth without significantly affecting blood cholesterol levels, and warrant further investigation for pancreatic cancer prevention and treatment.
Journal ArticleDOI
Safety assessment of coriander (Coriandrum sativum L.) essential oil as a food ingredient.
TL;DR: The use of coriander oil as an added food ingredient is considered safe at present levels of use because of the history of consumption without reported adverse effects, lack of its toxicity in limited studies and lack of toxicity of its major constituent, linalool.
Journal ArticleDOI
A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients☆
D. Belsito,David R. Bickers,Magnus Bruze,Peter Calow,Helmut Greim,Jon M. Hanifin,Adrianne E. Rogers,Jean-Hilaire Saurat,I. G. Sipes,Hachiro Tagami +9 more
TL;DR: University of Missouri (Kansas City), c/o American Dermatology Associates, LLC, 6333 Long Avenue, Third Floor, Shawnee, KS 66216, USA Columbia University Medical Center, Department of Dermatologists, 161 Fort Washington Avenue, New York, NY 10032.
Journal ArticleDOI
Fragrance material review on linalool.
TL;DR: A toxicologic and dermatologic review of linalool when used as a fragrance ingredient, is presented.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
Partial purification of cytochromes P-450 and P-448 from rat liver microsomes.
Anthony Y. H. Lu,Wayne Levin +1 more
TL;DR: Cytochromes P-450 and P-448 were solubilized and partially purified from rat liver microsomes and exhibited different substrate specificities for benzphetamine and 3,4-benzpyrene.
Journal ArticleDOI
Characterization of a cytochrome P-450 dependent monoterpene hydroxylase from the higher plant Vinca rosea.
TL;DR: A monooxygenase isolated from 5-day old etiolated Vinca rosea seedlings was shown to catalyze the hydroxylation of the monoterpene alcohols, geraniol and nerol, to their corresponding 10-hydroxy derivatives.
Journal ArticleDOI
Hydroxylation of geraniol and nerol by a monooxygenase from Vinca rosea
TL;DR: A microsomal mixed function oxidase isolated from V. rosea seedlings was shown to catalyze the hydroxylation of the monoterpene alcohols, geraniol and nerol, to their corresponding 10-hydroxy derivatives as mentioned in this paper.