Journal ArticleDOI
Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.
Dirk Montag,Karl Peter Giese,Udo Bartsch,Rudolf Martini,Yolande Lang,Horst Blüthmann,Jeevajothie Karthigasan,Daniel A. Kirschner,Eva Sabine Wintergerst,Klaus-Armin Nave,Jürgen Zielasek,Klaus V. Toyka,Hans-Peter Lipp,Melitta Schachner +13 more
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TLDR
Observations suggest that MAG participates in the formation of the periaxonal cytoplasmic collar of oligodendrocytes and in the recognition between oligodendedrocyte processes and axons.About:
This article is published in Neuron.The article was published on 1994-07-01. It has received 351 citations till now. The article focuses on the topics: Myelin basic protein & Oligodendrocyte.read more
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Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
TL;DR: This review deals with the recent progress related to the origin and differentiation of the oligodendrocytes, their relationships to other neural cells, and functional neuroglial interactions under physiological conditions and in demyelinating diseases.
Journal ArticleDOI
A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration
TL;DR: It is demonstrated that the myelin-associated glycoprotein (MAG), a transmembrane protein of both CNS and PNS myelin, strongly inhibits neurite outgrowth from both developing cerebellar and adult dorsal root ganglion (DRG) neurons in vitro and is reversed by an anti-MAG antibody.
Journal ArticleDOI
White matter changes in schizophrenia: evidence for myelin-related dysfunction.
Kenneth L. Davis,Daniel G. Stewart,Joseph I. Friedman,Monte S. Buchsbaum,Philip D. Harvey,Patrick R. Hof,Joseph D. Buxbaum,Vahram Haroutunian +7 more
TL;DR: Support for the hypothesis that oligodendroglial dysfunction and even death, with subsequent abnormalities in myelin maintenance and repair, contribute to the schizophrenic syndrome is supported.
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Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth.
Marco Domeniconi,Zixuan Cao,Tim Spencer,Rajeev Sivasankaran,Kevin C. Wang,Elena Nikulina,Noriko Kimura,Hong Cai,Kangwen Deng,Ying Gao,Zhigang He,Marie T. Filbin +11 more
TL;DR: It is shown that MAG inhibits regeneration by interaction with NgR, a GPI-linked receptor for Nogo (NgR) that has been identified, and suggests redundancy in myelin inhibitors and indicate therapies for CNS injuries.
Journal ArticleDOI
Axon-Glial Signaling and the Glial Support of Axon Function
Klaus-Armin Nave,Bruce D. Trapp +1 more
TL;DR: Mutations in the mouse reveal that axonal support by oligodendrocytes is independent of myelin assembly, suggesting that loss of glial support causes progressive axon degeneration and possibly local inflammation, both of which are likely to contribute to a variety of neuronal diseases in the central and peripheral nervous systems.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
TL;DR: A method has been devised for the electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets that results in quantitative transfer of ribosomal proteins from gels containing urea.