microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells
Elena Vigorito,Kerry L. Perks,Cei Abreu-Goodger,Sam F Bunting,Zou Xiang,Susan Kohlhaas,Partha Pratim Das,Eric A. Miska,Antony Rodriguez,Allan Bradley,Kenneth G. C. Smith,Cristina Rada,Anton J. Enright,Kai-Michael Toellner,Ian C. M. MacLennan,Martin R Turner +15 more
TLDR
The intrinsic requirement for miR-155 is shown in B cell responses to thymus-dependent and -independent antigens and implicate post-transcriptional regulation of gene expression for establishing the terminal differentiation program of B cells.About:
This article is published in Immunity.The article was published on 2007-12-21 and is currently open access. It has received 789 citations till now. The article focuses on the topics: B-1 cell & CD40.read more
Citations
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The evolution of gene regulation by transcription factors and microRNAs
Kevin Chen,Nikolaus Rajewsky +1 more
TL;DR: This work proposes a simple model that describes the transcriptional regulation of new microRNAs, a large class of small, non-coding RNAs in plants and animals, focusing on the evolution of the individual regulators and their binding sites.
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Physiological and pathological roles for microRNAs in the immune system
TL;DR: Recent advances in understanding of both the intended functions of miRNAs in managing immune cell biology and their pathological roles when their expression is dysregulated are discussed.
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miRecords: an integrated resource for microRNA–target interactions
TL;DR: The miRecords as mentioned in this paper database contains 1135 records of validated miRNA-target interactions between 301 miRNAs and 902 target genes in seven animal species in seven species.
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B lymphocytes: how they develop and function
TL;DR: P perturbations in B-cell development that give rise to certain types of congenital immunodeficiency, leukemia/lymphoma, and autoimmune disease are discussed in the context of normal B- cell development and selection.
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MicroRNAs in development and disease.
Danish Sayed,Maha Abdellatif +1 more
TL;DR: The discovery, structure, and mode of function of miRNAs in mammalian cells are described, before elaborating on their roles and significance during development and pathogenesis in the various mammalian organs, while attempting to reconcile their functions with the existing knowledge of their targets.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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miRBase: microRNA sequences, targets and gene nomenclature
TL;DR: The miRBase database aims to provide integrated interfaces to comprehensive microRNA sequence data, annotation and predicted gene targets, and acts as an independent arbiter of microRNA gene nomenclature.
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Identification of tissue-specific microRNAs from mouse
Mariana Lagos-Quintana,Reinhard Rauhut,Abdullah Yalcin,Jutta Meyer,Winfried Lendeckel,Thomas Tuschl +5 more
TL;DR: 34 novel miRNAs were identified by tissue-specific cloning of approximately 21-nucleotide RNAs from mouse and a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA.
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The microRNA Registry
TL;DR: The miRNA Registry provides a service for the assignment of miRNA gene names prior to publication and a comprehensive and searchable database of published miRNA sequences is accessible via a web interface.
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Principles of MicroRNA–Target Recognition
TL;DR: The minimal requirements for functional miRNA–target duplexes in vivo are evaluated and classes of target sites with different functional properties are distinguished, indicating that miRNAs regulate a large fraction of protein-coding genes and that miRNA 3′ ends are key determinants of target specificity within miRNA families.