Mind the gap: why many geneticists and psychological scientists have discrepant views about gene-environment interaction (G×E) research.
Reads0
Chats0
TLDR
The differences in perspective between psychiatric geneticists and psychological scientists that have contributed to a growing divide between the research cited and conducted by these two related disciplines are described.Abstract:
As our field seeks to elucidate the biopsychosocial etiologies of mental health disorders, many traditional psychological and social science researchers have added, or plan to add, genetic components to their programs of research. An understanding of the history, methods, and perspectives of the psychiatric genetics community is useful in this pursuit. In this article we provide a brief overview of psychiatric genetic methods and findings. This overview lays the groundwork for a more thorough review of gene-environment interaction (G×E) research and the candidate gene approach to G×E research that remains popular among many psychologists and social scientists. We describe the differences in perspective between psychiatric geneticists and psychological scientists that have contributed to a growing divide between the research cited and conducted by these two related disciplines. Finally, we outline a strategy for the future of research on gene-environment interactions that capitalizes on the relative strengths of each discipline. (PsycINFO Database Record (c) 2014 APA, all rights reserved).read more
Citations
More filters
Journal ArticleDOI
Analysis of polygenic risk score usage and performance in diverse human populations
Laramie E. Duncan,Hanyang Shen,Bizu Gelaye,J. Meijsen,Kerry J. Ressler,Marcus W. Feldman,Roseann E. Peterson,Benjamin W. Domingue +7 more
TL;DR: Findings highlight the need for improved treatment of linkage disequilibrium and variant frequencies when applying polygenic scoring to cohorts of non-European ancestry, and bolster the rationale for large-scale GWAS in diverse human populations.
Journal ArticleDOI
Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations
Roseann E. Peterson,Karoline Kuchenbaecker,Raymond K. Walters,Chia-Yen Chen,Alice B. Popejoy,Sathish Periyasamy,Max Lam,Max Lam,Conrad Iyegbe,Rona J. Strawbridge,Leslie A. Brick,Caitlin E. Carey,Alicia R. Martin,Alicia R. Martin,Jacquelyn L. Meyers,Jinni Su,Junfang Chen,Alexis C. Edwards,Allan Kalungi,Nastassja Koen,Lerato Majara,Emanuel Schwarz,Jordan W. Smoller,Eli A. Stahl,Patrick F. Sullivan,Evangelos Vassos,Bryan J. Mowry,Miguel L. Prieto,Alfredo B. Cuellar-Barboza,Tim B. Bigdeli,Howard J. Edenberg,Hailiang Huang,Hailiang Huang,Laramie E. Duncan +33 more
TL;DR: To facilitate and promote research in multi-ancestry and admixed cohorts, key methodological considerations are outlined and opportunities, challenges, solutions, and areas in need of development are highlighted.
Journal ArticleDOI
The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.
TL;DR: Evidence for genetic contributions to PTSD, MDD, and the anxiety disorders including genetic epidemiology, the role of common genetic variation, the roles of rare and structural variation, andThe role of gene–environment interaction are summarized.
Reference EntryDOI
Resilience in Development: Progress and Transformation
Ann S. Masten,Dante Cicchetti +1 more
TL;DR: This paper reviewed origins and progress in resilience science, with an emphasis on progress over the past decade in theory, findings, and translational applications for strategic intervention, including new approaches to test resilience-related processes in such models.
Journal ArticleDOI
Rethinking the biopsychosocial model of health: Understanding health as a dynamic system
TL;DR: In this paper, a dynamic biopsychosocial model is proposed to constrain human health as a product of the reciprocal influences of biological, psychological, interpersonal, and macrosystem contextual dynamics that unfold over personal and historical time.
References
More filters
Journal ArticleDOI
An integrated encyclopedia of DNA elements in the human genome
TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.
Journal ArticleDOI
Finding the missing heritability of complex diseases
Teri A. Manolio,Francis S. Collins,Nancy J. Cox,David Goldstein,Lucia A. Hindorff,David J. Hunter,Mark I. McCarthy,Erin M. Ramos,Lon R. Cardon,Aravinda Chakravarti,Judy H. Cho,Alan E. Guttmacher,Augustine Kong,Leonid Kruglyak,Leonid Kruglyak,Elaine R. Mardis,Charles N. Rotimi,Montgomery Slatkin,David Valle,Alice S. Whittemore,Michael Boehnke,Andrew G. Clark,Evan E. Eichler,Greg Gibson,Jonathan L. Haines,Trudy F. C. Mackay,Steven A. McCarroll,Peter M. Visscher +27 more
TL;DR: This paper examined potential sources of missing heritability and proposed research strategies, including and extending beyond current genome-wide association approaches, to illuminate the genetics of complex diseases and enhance its potential to enable effective disease prevention or treatment.
Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
Journal ArticleDOI
GCTA: a tool for genome-wide complex trait analysis.
TL;DR: The GCTA software is a versatile tool to estimate and partition complex trait variation with large GWAS data sets and focuses on the function of estimating the variance explained by all the SNPs on the X chromosome and testing the hypotheses of dosage compensation.
Related Papers (5)
Beyond Diathesis Stress: Differential Susceptibility to Environmental Influences.
Jay Belsky,Michael Pluess +1 more