miRWalk - Database: Prediction of possible miRNA binding sites by walking the genes of three genomes
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TLDR
The miRWalk database as mentioned in this paper is a comprehensive database on miRNAs, which hosts predicted as well as validated miRNA binding sites, information on all known genes of human, mouse and rat.About:
This article is published in Journal of Biomedical Informatics.The article was published on 2011-10-01 and is currently open access. It has received 1603 citations till now. The article focuses on the topics: MiRNA binding & Untranslated region.read more
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miR-18a Inhibits CDC42 and Plays a Tumour Suppressor Role in Colorectal Cancer Cells
TL;DR: The homeostatic function ofmiR-18a within the miR-17-92 cluster in colorectal cancer cells may be achieved through suppression of CDC42 and the PI3K pathway.
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MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson's Disease.
Yimeng Chen,Yimeng Chen,Chao Gao,Qian Sun,Hong Pan,Hong Pan,Pei Huang,Jianqing Ding,Sheng-Di Chen,Sheng-Di Chen +9 more
TL;DR: Hsa-miR-4639-5p level was identified to be significantly up-regulated in PD patients and was able to discriminate between early PD patients (disease duration ≤2 years or Hoehn and Yahr stage 1–2.5) and healthy controls.
Journal ArticleDOI
Serum and amygdala microRNA signatures of posttraumatic stress: Fear correlation and biomarker potential
Nagaraja S. Balakathiresan,Raghavendar Chandran,Raghavendar Chandran,Manish Bhomia,Min Jia,He Li,Radha K. Maheshwari +6 more
TL;DR: Validations by bioinformatics and system biology approaches indicate that five miRNAs may play a potential role in the regulation of genes associated with delayed and exaggerated fear, the first report demonstrating the plausibility of using circulating miRN as biomarkers of PTSD.
Journal ArticleDOI
Functional miRNAs in breast cancer drug resistance
TL;DR: This review particularly focuses on enumerating functional miRNAs involved in breast cancer drug resistance as well as their targets and related mechanisms, and discusses the prospects and challenges of miRNA function in drug resistance.
Book
Evolutionary Bioinformatics
TL;DR: This research presents a novel probabilistic method called “spot-time PCR” that allows for real-time analysis of the response of the immune system to natural disasters.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
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Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.