miRWalk - Database: Prediction of possible miRNA binding sites by walking the genes of three genomes
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TLDR
The miRWalk database as mentioned in this paper is a comprehensive database on miRNAs, which hosts predicted as well as validated miRNA binding sites, information on all known genes of human, mouse and rat.About:
This article is published in Journal of Biomedical Informatics.The article was published on 2011-10-01 and is currently open access. It has received 1603 citations till now. The article focuses on the topics: MiRNA binding & Untranslated region.read more
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Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma.
Giulio Fiaschetti,Lucia Abela,N Nonoguchi,Adrian M. Dubuc,Marc Remke,A Boro,E Grunder,Ulrich Siler,Hiroko Ohgaki,Michael D. Taylor,Martin Baumgartner,Tarek Shalaby,Michael A. Grotzer +12 more
TL;DR: Re-expression of microRNA-9 may constitute a novel epigenetic regulation strategy against medulloblastoma, a methylation-silenced tumour suppressor that could be a potential candidate predictive marker for poor prognosis of medullOBlastoma.
Journal ArticleDOI
Differential MicroRNA Expression in Human Macrophages with Mycobacterium tuberculosis Infection of Beijing/W and Non-Beijing/W Strain Types
TL;DR: It is shown for the first time that the Beijing/W TB strains repressed a number of miRNAs expressions which may reflect their virulence characteristics in altering the host response.
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DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer
Alexandra Kalmár,Alexandra Kalmár,Bálint Péterfia,Bálint Péterfia,Péter Hollósi,Péter Hollósi,Orsolya Galamb,Sándor Spisák,Barnabás Wichmann,András Bodor,Kinga Tóth,Árpád V. Patai,Gábor Valcz,Zsófia Brigitta Nagy,Vivien Kubak,Zsolt Tulassay,Zsolt Tulassay,Ilona Kovalszky,Béla Molnár,Béla Molnár +19 more
TL;DR: Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
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Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.
Abhijeet Bakre,Lauren E. Andersen,Victoria A. Meliopoulos,Keegan Coleman,Xiuzhen Yan,Paula Brooks,Jackelyn Crabtree,S. Mark Tompkins,Ralph A. Tripp +8 more
TL;DR: Findings identify HPKs important for influenza viral replication and show the miRNAs that govern their expression.
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Meta-Analyses of Microarray Datasets Identifies ANO1 and FADD as Prognostic Markers of Head and Neck Cancer
Ram Bhupal Reddy,Anupama Rajan Bhat,Bonney Lee James,Sindhu Govindan,Rohit Mathew,Ravindra Dr,Naveen Hedne,Jeyaram Illiayaraja,Vikram Kekatpure,Samanta S. Khora,Wesley L. Hicks,Pramila Tata,Moni Abraham Kuriakose,Amritha Suresh +13 more
TL;DR: The meta-analysis approach adopted in this study has identified candidate markers correlated with disease outcome in HNSCC and showed that ANO1 and FADD were co-expressed at transcript level and significantly associated with overall and disease-free survival.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
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MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.