miRWalk - Database: Prediction of possible miRNA binding sites by walking the genes of three genomes
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TLDR
The miRWalk database as mentioned in this paper is a comprehensive database on miRNAs, which hosts predicted as well as validated miRNA binding sites, information on all known genes of human, mouse and rat.About:
This article is published in Journal of Biomedical Informatics.The article was published on 2011-10-01 and is currently open access. It has received 1603 citations till now. The article focuses on the topics: MiRNA binding & Untranslated region.read more
Citations
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Effects of Rosmarinus officinalis extract on human primary omental preadipocytes and adipocytes.
TL;DR: It is indicated that RO extract modulates human adipocyte differentiation and significantly interferes with adipogenesis and lipid metabolism, supporting its interest as dietary supplement.
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CircSPI1 acts as an oncogene in acute myeloid leukemia through antagonizing SPI1 and interacting with microRNAs.
TL;DR: In this paper, the authors found that circSPI1, derived from the SPI1 gene, is highly expressed in acute myeloid leukemia (AML) but not in normal counterparts.
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Identification and functional analysis of a potential key lncRNA involved in fat loss of cancer cachexia.
TL;DR: Weighted gene co‐expression network analysis (WGCNA) was applied to identify cachexia related gene modules using differentially expressed 3289 genes and 59 long non‐coding RNAs based on microarray data of cachectic and non‐cachectic subcutaneous adipose tissue and predicted that VLDLR‐AS1 most likely interacted with miR‐600 to regulate UCH‐L1 through Wnt/β‐catenin signaling pathway.
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Long noncoding RNA HCG18 inhibits the differentiation of human bone marrow-derived mesenchymal stem cells in osteoporosis by targeting miR-30a-5p/NOTCH1 axis
TL;DR: Lentivirus mediated HCG18 knockdown on the bone-formation surfaces of hindlimb-unloaded mice partially alleviated unloading-induced bone loss and can be identified as a regulator of osteogenic differentiation of BMSCs.
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Genome-wide microRNA and messenger RNA profiling in rodent liver development implicates mir302b and mir20a in repressing transforming growth factor-beta signaling†
Wei Wei,Juan Hou,Olivia Alder,Xin Ye,Xin Ye,Sam Lee,Rebecca L. Cullum,Andy Chu,Yongjun Zhao,Stephanie M. Warner,Darryl A. Knight,Darryl A. Knight,Decheng Yang,Decheng Yang,Steven J.M. Jones,Steven J.M. Jones,Marco A. Marra,Marco A. Marra,Pamela A. Hoodless,Pamela A. Hoodless +19 more
TL;DR: Through targeting Tgfbr2, mir302b and mir20a are able to regulate transforming growth factor beta (TGFβ) signal transduction and can repress liver markers in an embryonic stem cell differentiation model.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
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MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
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Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.