miRWalk - Database: Prediction of possible miRNA binding sites by walking the genes of three genomes
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TLDR
The miRWalk database as mentioned in this paper is a comprehensive database on miRNAs, which hosts predicted as well as validated miRNA binding sites, information on all known genes of human, mouse and rat.About:
This article is published in Journal of Biomedical Informatics.The article was published on 2011-10-01 and is currently open access. It has received 1603 citations till now. The article focuses on the topics: MiRNA binding & Untranslated region.read more
Citations
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Book ChapterDOI
Visualization and Analysis of MiRNA–Targets Interactions Networks
TL;DR: In this paper, bioinformatics guidelines are described to use miRWalk database and Cytoscape software for analyzing microRNA-mRNA interactions through their visualization as a network.
Journal ArticleDOI
Micro rna hsa-486-3p gene expression profiling in the whole blood of patients with autism
TL;DR: Molecular evidence for a differentially expressed miR486-3p which has shown brain-specific expression with possible roles in human neuronal differentiation is reported, a finding which suggests that dysregulation of miRNAs may contribute to autism phenotype.
Journal ArticleDOI
Construction of an miRNA-regulated drug-pathway network reveals drug repurposing candidates for myasthenia gravis
Yuze Cao,Xiaoyan Lu,Jianjian Wang,Huixue Zhang,Zhaojun Liu,Si Xu,Tianfeng Wang,Shangwei Ning,Bo Xiao,Lihua Wang +9 more
TL;DR: Novel insight is provided into the pathogenesis of MG and potential drug candidates for MG were identified and an miRNA-regulated drug-pathway network was constructed and miRNAs and drugs that synergistically regulate key MG pathways and biological processes were identified.
Book ChapterDOI
A Practical Guide to miRNA Target Prediction
Most Mauluda Akhtar,Luigina Micolucci,Soriful Islam,Fabiola Olivieri,Antonio Domenico Procopio +4 more
TL;DR: This chapter presents the major features that most algorithms take into account to efficiently predict miRNA target: seed match, free energy, conservation, target site accessibility, and contribution of multiple binding sites.
Journal ArticleDOI
Analysis of microRNA Expression Profiles Induced by Yiqifumai Injection in Rats with Chronic Heart Failure.
TL;DR: YQFM has a potential effect on alleviate cardiac hypertrophy and apoptosis in chronic heart failure and provided scientific evidence to uncover the mechanism of action of YQFM on miRNAs regulation against CHF by miRNA expression profile technology.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.