miRWalk - Database: Prediction of possible miRNA binding sites by walking the genes of three genomes
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TLDR
The miRWalk database as mentioned in this paper is a comprehensive database on miRNAs, which hosts predicted as well as validated miRNA binding sites, information on all known genes of human, mouse and rat.About:
This article is published in Journal of Biomedical Informatics.The article was published on 2011-10-01 and is currently open access. It has received 1603 citations till now. The article focuses on the topics: MiRNA binding & Untranslated region.read more
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MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits
Leif Hommers,Annette Raab,Alexandra Bohl,Heike Weber,Claus-Jürgen Scholz,Angelika Erhardt,Elisabeth B. Binder,Volker Arolt,Alexander L. Gerlach,Andrew T. Gloster,Raffael Kalisch,Tilo Kircher,Tina B. Lonsdorf,Andreas Ströhle,Peter Zwanzger,Manuel Mattheisen,Sven Cichon,Sven Cichon,Sven Cichon,Klaus-Peter Lesch,Katharina Domschke,Andreas Reif,Martin J. Lohse,Jürgen Deckert +23 more
TL;DR: Dimensional anxiety traits, as described by Anxiety Sensitivity Index and Agoraphobic Cognitions Questionnaire, were significantly higher among carriers of both major (G) alleles in a combined patient/control sample and data indicate that MIR4717 regulates human RGS2 and contributes to the genetic risk towards anxiety‐related traits.
Journal Article
Oncogenic miR-137 contributes to cisplatin resistance via repressing CASP3 in lung adenocarcinoma.
Te Jen Su,Wen Hui Ku,Hsuan-Yu Chen,Yi Chiung Hsu,Qi Sheng Hong,Gee-Chen Chang,Sung-Liang Yu,Jeremy J.W. Chen +7 more
TL;DR: The data indicated that miR-137 overexpression increases the survival of lung cancer cells exposed to cisPlatin and decreases cisplatin-induced apoptosis, and provides a new chemoresistance mechanism in lung adenocarcinoma patients.
Journal ArticleDOI
MiR-138 indirectly regulates the MDR1 promoter by NF-κB/p65 silencing.
J.L. Requenez-Contreras,E.S. López-Castillejos,R. Hernández-Flores,Mario Adán Moreno-Eutimio,Javier T. Granados-Riveron,G.U. Martinez-Ruiz,Guillermo Aquino-Jarquin +6 more
TL;DR: The results of luciferase reporter assay, western blot and flow cytometry suggest that miR-138 might modulate the human MDR1 expression by inhibiting NF-κB/p65 as an indirect mechanism of MDR 1 regulation.
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miR-21 silencing ameliorates experimental autoimmune encephalomyelitis by promoting the differentiation of IL-10-producing B cells.
TL;DR: A B cell-intrinsic microRNA pathway that inhibits the differentiation of IL-10+ Breg cells and promotes autoimmunity is characterized and miR-21 silencing represents a new therapeutic strategy for the treatment of autoimmune diseases.
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Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy
Prashant K. Srivastava,Paolo Roncon,Katarzyna Lukasiuk,Jan A. Gorter,Eleonora Aronica,Asla Pitkänen,Enrico Petretto,Marvin Johnson,Michele Simonato +8 more
TL;DR: A meta-analysis of changes in miRNA expression in the hippocampal dentate gyrus following an epileptogenic insult in three epilepsy models identifies new miRNAs associated with epileptogenesis from existing data, highlighting the utility of meta- analysis in maximizing value from preclinical data.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
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MicroRNA expression profiles classify human cancers
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TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
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Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.