miRWalk - Database: Prediction of possible miRNA binding sites by walking the genes of three genomes
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TLDR
The miRWalk database as mentioned in this paper is a comprehensive database on miRNAs, which hosts predicted as well as validated miRNA binding sites, information on all known genes of human, mouse and rat.About:
This article is published in Journal of Biomedical Informatics.The article was published on 2011-10-01 and is currently open access. It has received 1603 citations till now. The article focuses on the topics: MiRNA binding & Untranslated region.read more
Citations
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Role of Multiple MicroRNAs in the Sexually Dimorphic Expression of Cyp2b9 in Mouse Liver
Xiaofeng Xie,Lingling Miao,Jun Yao,Chenchen Feng,Chenggang Li,Man Gao,Mingxia Liu,Likun Gong,Yizheng Wang,Xinming Qi,Jin Ren +10 more
TL;DR: Evidence is found that some microRNAs contributed to the sexually biased expression of Cyp2b9 via post-transcriptional regulation through transcriptional regulation and that the lower expression levels of these micro RNAs potentially contributed toThe female-specific expression of cytochrome P450 2b9 in the livers of C57BL/6J mice.
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Transcription factors and microRNA-co-regulated genes in gastric cancer invasion in ex vivo.
TL;DR: This study found eighteen differentially expressed genes that were co-regulated by transcription factors and miRNAs that were part of the extracellular matrix-receptor interaction and focal adhesion signaling pathways and provided the first evidence that altered gene network was associated with gastric cancer invasion.
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MicroRNA-23b-3p regulates human keratinocyte differentiation through repression of TGIF1 and activation of the TGF-ß-SMAD2 signalling pathway.
Laetitia Barbollat-Boutrand,Laetitia Barbollat-Boutrand,Nicolas Joly-Tonetti,Nicolas Joly-Tonetti,Morgan Dos Santos,Elodie Metral,Aurélie Boher,Ingrid Masse,Ingrid Masse,Odile Berthier-Vergnes,Odile Berthier-Vergnes,Philippe Bertolino,Odile Damour,Jérôme Lamartine,Jérôme Lamartine +14 more
TL;DR: The data identified miR‐23b‐3p as a new regulator of human epidermal differentiation in line with TGF‐ß signalling, and it was shown that he was able to activate TGF-ß signalling in human keratinocytes by increasing SMAD2 phosphorylation through TGIF1 repression.
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Role of microRNA in CB1 antagonist–mediated regulation of adipose tissue macrophage polarization and chemotaxis during diet-induced obesity
Pegah Mehrpouya-Bahrami,Kathryn Miranda,Narendra P. Singh,Elizabeth E. Zumbrun,Mitzi Nagarkatti,Prakash S. Nagarkatti +5 more
TL;DR: It is demonstrated for the first time that CB1 receptor blockade attenuates DIO-associated inflammation through alterations in ATM miR expression that promote M2 ATM polarization and macrophage egress from adipose tissue.
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EphB2 contributes to human naive B-cell activation and is regulated by miR-185
Miao Yu,Wei Liang,Shuang Wen,Tong Zhao,Ming-Xin Zhu,Huan-Huan Li,Qi Long,Min Wang,Xiang Cheng,Yuhua Liao,Jing Yuan +10 more
TL;DR: EphB2 contributes to human naive B‐cell activation and is regulated by miR‐185, and microRNAs that could regulate EphB 2 expression in B cells were screened, and it was discovered that miR •185 directly targeted to Eph B2 mRNA and suppressed its expression.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
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MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.