Journal ArticleDOI
Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality.
TLDR
This research provides a paradigm that framework organic-inorganic hybridization can endow the inorganic nanocarrier with unique biological effects suitable for biomedical application, benefiting the development of novel nanosystems with the unique bio-functionality and performance.About:
This article is published in Biomaterials.The article was published on 2017-05-01. It has received 166 citations till now. The article focuses on the topics: Mesoporous organosilica & Mesoporous silica.read more
Citations
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Journal ArticleDOI
Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy
Han Lin,Yu Chen,Jianlin Shi +2 more
TL;DR: This tutorial review summarizes the very-recent research progress in the design and synthesis of representative nanoplatforms with intriguing nanostructures, compositions, physiochemical properties and biological behaviours for versatile catalytic chemical reaction-enabled cancer treatments, mainly by either endogenous tumour microenvironment triggering or exogenous physical irradiation.
Journal ArticleDOI
Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications.
TL;DR: Trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.
Journal ArticleDOI
Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation.
Piao Zhu,Yu Chen,Jianlin Shi +2 more
TL;DR: High in vivo biocompatibility and easy excretion of these multifunctional nanosonosensitizers from the body have been evaluated and demonstrated to guarantee their future clinical translation, and their TME-responsive T1-weighted magnetic resonance imaging capability provides the potential for therapeutic guidance and monitoring during SDT.
Journal ArticleDOI
Synthesis and Biomedical Applications of Multifunctional Nanoparticles
TL;DR: Various components to construct the multifunctional NP agents, which include polymers and mesoporous, magnetic, catalytic, and semiconducting NPs, are discussed together with their overall integration forms, such as NP assembly, hollow/porous structures, or hybrid/doped systems.
Journal ArticleDOI
Mesoporous Organosilica Hollow Nanoparticles: Synthesis and Applications
TL;DR: Recent advances in the synthesis of hollow PMO nanoparticles with various organic moieties with molecularly homogeneous organic functional groups in the inorganic pore walls are summarized, and the mechanism and new insights of synthesis approaches, including hard-core templating methods, liquid-interface assembly methods, andThe interfacial reassembly and transformation strategy are discussed in-depth.
References
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Journal ArticleDOI
Inorganic nanoparticle-based drug codelivery nanosystems to overcome the multidrug resistance of cancer cells.
TL;DR: These elaborately designed biocompatible inorganic materials-based nanosystems offer an unprecedented opportunity and show the encouraging bright future for overcoming the MDR of tumors in clinic personalized medicine and the pharmaceutical industry.
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Glutathione- and pH-responsive nonporous silica prodrug nanoparticles for controlled release and cancer therapy
TL;DR: The results suggest that the stimuli-responsive silica prodrug NPs are promising anticancer drug carriers for efficient cancer therapy.
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Breakable Hybrid Organosilica Nanocapsules for Protein Delivery
Eko Adi Prasetyanto,Alessandro Bertucci,Alessandro Bertucci,Dedy Septiadi,Roberto Corradini,Pablo Castro-Hartmann,Luisa De Cola,Luisa De Cola +7 more
TL;DR: It is demonstrated that the shell is broken, the release of the active proteins occurs, and therefore the hybrid architecture is a promising strategy to deliver fragile biomacromolecules into living organisms.
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A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging.
Matti M. van Schooneveld,David P. Cormode,Rolf Koole,J. Timon van Wijngaarden,Claudia Calcagno,Torjus Skajaa,Jan Hilhorst,Dannis C. 't Hart,Zahi A. Fayad,Willem J. M. Mulder,Andries Meijerink +10 more
TL;DR: In this paper, gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle-enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT.
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Ordered Mesoporous Materials in the Context of Drug Delivery Systems and Bone Tissue Engineering
TL;DR: In this paper, the authors introduce an example of such an interaction, aimed at solving health issues within the world of biomaterials, which can be loaded with different organic molecules that would be released afterwards, in a controlled fashion, inside a living body.