Journal ArticleDOI
Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality.
TLDR
This research provides a paradigm that framework organic-inorganic hybridization can endow the inorganic nanocarrier with unique biological effects suitable for biomedical application, benefiting the development of novel nanosystems with the unique bio-functionality and performance.About:
This article is published in Biomaterials.The article was published on 2017-05-01. It has received 166 citations till now. The article focuses on the topics: Mesoporous organosilica & Mesoporous silica.read more
Citations
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Journal ArticleDOI
Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy
Han Lin,Yu Chen,Jianlin Shi +2 more
TL;DR: This tutorial review summarizes the very-recent research progress in the design and synthesis of representative nanoplatforms with intriguing nanostructures, compositions, physiochemical properties and biological behaviours for versatile catalytic chemical reaction-enabled cancer treatments, mainly by either endogenous tumour microenvironment triggering or exogenous physical irradiation.
Journal ArticleDOI
Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications.
TL;DR: Trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.
Journal ArticleDOI
Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation.
Piao Zhu,Yu Chen,Jianlin Shi +2 more
TL;DR: High in vivo biocompatibility and easy excretion of these multifunctional nanosonosensitizers from the body have been evaluated and demonstrated to guarantee their future clinical translation, and their TME-responsive T1-weighted magnetic resonance imaging capability provides the potential for therapeutic guidance and monitoring during SDT.
Journal ArticleDOI
Synthesis and Biomedical Applications of Multifunctional Nanoparticles
TL;DR: Various components to construct the multifunctional NP agents, which include polymers and mesoporous, magnetic, catalytic, and semiconducting NPs, are discussed together with their overall integration forms, such as NP assembly, hollow/porous structures, or hybrid/doped systems.
Journal ArticleDOI
Mesoporous Organosilica Hollow Nanoparticles: Synthesis and Applications
TL;DR: Recent advances in the synthesis of hollow PMO nanoparticles with various organic moieties with molecularly homogeneous organic functional groups in the inorganic pore walls are summarized, and the mechanism and new insights of synthesis approaches, including hard-core templating methods, liquid-interface assembly methods, andThe interfacial reassembly and transformation strategy are discussed in-depth.
References
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Journal ArticleDOI
Periodic Mesoporous Organosilica Hollow Spheres with Tunable Wall Thickness
TL;DR: Periodic mesoporous organosilica hollow spheres with tunable wall thickness have been successfully synthesized by a new vesicle and a liquid crystal "dual templating" mechanism, which may be applicable for drug and DNA delivery systems, biomolecular encapsulation, as well as nanoreactors for conducting biological reactions at the molecular levels.
Journal ArticleDOI
Periodic mesoporous organosilicas containing interconnected [Si(CH2)]3 rings.
TL;DR: A periodic mesoporous organosilica composed of interconnected three-ring [Si(CH2)]3 units built of three SiO2( CH2)2 tetrahedral subunits is reported, which represents the archetype of a previously unknown class of nanocomposite materials in which two bridging organic groups are bound to each silicon atom.
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Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy.
Meiying Wu,Qingshuo Meng,Yu Chen,Lingxia Zhang,Mengli Li,Xiaojun Cai,Yaping Li,Pengcheng Yu,Linlin Zhang,Jianlin Shi +9 more
TL;DR: A stability-difference-selective bond-breakage strategy for the fabrication of largepore-sized hollow mesoporous organosilica nanoparticles (HMONs) is successfully developed and surfacefunctionalized HMONs are successfully constructed to simultaneously deliver P-gp modulator siRNA and anticancer drug doxorubicin to reverse the multidrug resistance of cancer cells.
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A Facile Multi-interface Transformation Approach to Monodisperse Multiple-Shelled Periodic Mesoporous Organosilica Hollow Spheres.
Zhaogang Teng,Xiaodan Su,Yuanyi Zheng,Junjie Zhang,Ying Liu,Shouju Wang,Jiang Wu,Guotao Chen,Jiandong Wang,Dongyuan Zhao,Guangming Lu +10 more
TL;DR: It is proposed that the formation of the multi-shelled PMO hollow structures is ascribed to the creation of multiple highly cross-linked organosilica interfaces, providing a new and interesting fundamental principle for PMO materials.
Journal ArticleDOI
"Manganese Extraction" Strategy Enables Tumor-Sensitive Biodegradability and Theranostics of Nanoparticles.
TL;DR: This is the first demonstration of biodegradable inorganic mesoporous nanosystems with specific biodegrades behavior sensitive to tumor microenvironment, which also provides a feasible approach to realize the on-demand biodegradation of inorganic nanomaterials simply by "metal ion-doping" strategy, paving the way to solve the critical low-biodegradation issue of in organic drug carriers.