Journal ArticleDOI
Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality.
TLDR
This research provides a paradigm that framework organic-inorganic hybridization can endow the inorganic nanocarrier with unique biological effects suitable for biomedical application, benefiting the development of novel nanosystems with the unique bio-functionality and performance.About:
This article is published in Biomaterials.The article was published on 2017-05-01. It has received 166 citations till now. The article focuses on the topics: Mesoporous organosilica & Mesoporous silica.read more
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Journal ArticleDOI
Biodegradable and biocompatible monodispersed hollow mesoporous organosilica with large pores for delivering biomacromolecules
TL;DR: This first demonstration of the construction of molecularly organic-inorganic hybrid HMONs with a unique large mesopore size, hollow interior, a small particle size and tumor microenvironment-responsive biodegradability promises the intracellular delivery of biomacromolecules for various therapeutic applications, especially for combating cancer.
Journal ArticleDOI
Chitosan oligosaccharide coated mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications
Madhappan Santha Moorthy,Giang Hoang,Panchanathan Manivasagan,Sudip Mondal,Thi Tuong Vy Phan,Hyehyun Kim,Junghwan Oh +6 more
TL;DR: The in vitro cytotoxicity and fluorescence microscopic analysis results evidenced that the synthesized MSNs@COS NPs system is biocompatible and could be readily taken up by MDA-MB-231 cells, and it is believed that the proposed system could be applicable for pH-stimuli responsive controlled drug delivery applications in cancer therapy.
Journal ArticleDOI
Safety of Nonporous Silica Nanoparticles in Human Corneal Endothelial Cells.
TL;DR: The findings suggested that 50, 100, and 150 nm SiNPs did not induce acute significant cytotoxicity in corneal endothelial cells at concentrations up to 100 µg/mL, however, long-term toxicity of SiNNP remains unknown.
Journal ArticleDOI
Development of MCM-41 mesoporous silica nanoparticles as a platform for pramipexole delivery
Borislav Tzankov,Virginia Tzankova,Denitsa Aluani,Yordan Yordanov,Ivanka Spassova,Daniela Kovacheva,Kati Avramova,Massimo Valoti,Krassimira Yoncheva +8 more
TL;DR: It is found that pramipexole loaded MCM-41 particles showed a higher potential in preventing H2O2-induced oxidative damage in human neuroblastoma SH-SY5Y cells, compared to the free drug.
Journal ArticleDOI
Recent development in biodegradable nanovehicle delivery system-assisted immunotherapy.
TL;DR: This review article highlights the recent literature on the design and working mechanism of various biodegradable nanovehicle delivery systems (BNDSs), which are quite significant for potential clinical applications.
References
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Journal ArticleDOI
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Martin Lundqvist,Johannes Stigler,Giuliano Elia,Iseult Lynch,Tommy Cedervall,Kenneth A. Dawson +5 more
TL;DR: The long-lived (“hard”) protein corona formed from human plasma is studied for a range of nanoparticles that differ in surface properties and size and both size and surface properties were found to play a very significant role.
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Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
TL;DR: This review highlights the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers and envision that these MSN-based systems have a great potential for a variety of drug delivery applications.
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Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
TL;DR: The in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure.
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Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Horacio Cabral,Yu Matsumoto,Kazue Mizuno,Qixian Chen,Mami Murakami,M. Kimura,Yasuko Terada,Mitsunobu R. Kano,Kohei Miyazono,Mitsuru Uesaka,Nobuhiro Nishiyama,Kazunori Kataoka +11 more
TL;DR: It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours.
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Demonstration of a spaser-based nanolaser
Mikhail A. Noginov,Guohua Zhu,A. M. Belgrave,Reuben M. Bakker,Vladimir M. Shalaev,Evgenii E. Narimanov,S Stout,S Stout,Erik Herz,Teeraporn Suteewong,Ulrich Wiesner +10 more
TL;DR: It is shown that 44-nm-diameter nanoparticles with a gold core and dye-doped silica shell allow us to completely overcome the loss of localized surface plasmons by gain and realize a spaser, and that outcoupling of surface plasmon oscillations to photonic modes at a wavelength of 531 nm makes this system the smallest nanolaser reported to date—and to the authors' knowledge the first operating at visible wavelengths.