Journal ArticleDOI
Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality.
TLDR
This research provides a paradigm that framework organic-inorganic hybridization can endow the inorganic nanocarrier with unique biological effects suitable for biomedical application, benefiting the development of novel nanosystems with the unique bio-functionality and performance.About:
This article is published in Biomaterials.The article was published on 2017-05-01. It has received 166 citations till now. The article focuses on the topics: Mesoporous organosilica & Mesoporous silica.read more
Citations
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Journal ArticleDOI
Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy
Han Lin,Yu Chen,Jianlin Shi +2 more
TL;DR: This tutorial review summarizes the very-recent research progress in the design and synthesis of representative nanoplatforms with intriguing nanostructures, compositions, physiochemical properties and biological behaviours for versatile catalytic chemical reaction-enabled cancer treatments, mainly by either endogenous tumour microenvironment triggering or exogenous physical irradiation.
Journal ArticleDOI
Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications.
TL;DR: Trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.
Journal ArticleDOI
Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation.
Piao Zhu,Yu Chen,Jianlin Shi +2 more
TL;DR: High in vivo biocompatibility and easy excretion of these multifunctional nanosonosensitizers from the body have been evaluated and demonstrated to guarantee their future clinical translation, and their TME-responsive T1-weighted magnetic resonance imaging capability provides the potential for therapeutic guidance and monitoring during SDT.
Journal ArticleDOI
Synthesis and Biomedical Applications of Multifunctional Nanoparticles
TL;DR: Various components to construct the multifunctional NP agents, which include polymers and mesoporous, magnetic, catalytic, and semiconducting NPs, are discussed together with their overall integration forms, such as NP assembly, hollow/porous structures, or hybrid/doped systems.
Journal ArticleDOI
Mesoporous Organosilica Hollow Nanoparticles: Synthesis and Applications
TL;DR: Recent advances in the synthesis of hollow PMO nanoparticles with various organic moieties with molecularly homogeneous organic functional groups in the inorganic pore walls are summarized, and the mechanism and new insights of synthesis approaches, including hard-core templating methods, liquid-interface assembly methods, andThe interfacial reassembly and transformation strategy are discussed in-depth.
References
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Journal ArticleDOI
Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery
TL;DR: This review article provides a comprehensive overview of the controlled synthesis of PMO NPs and organo-bridged MSNs, physicochemical and biocompatible properties, and their nano-biomedical application as bioimaging agent and/or therapeutic agent delivery system.
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Biodegradable Ethylene‐Bis(Propyl)Disulfide‐Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In‐Vitro Drug Delivery
Jonas G. Croissant,Xavier Cattoën,Michel Wong Chi Man,Audrey Gallud,Laurence Raehm,Philippe Trens,Marie Maynadier,Jean-Olivier Durand +7 more
TL;DR: Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxYSilylpropyl)disulfide and are very efficient for doxorubicin delivery in these cells.
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Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer
Veronika Mamaeva,Jessica M. Rosenholm,Laurel T. Bate-Eya,Lotta Bergman,Emilia Peuhu,Alain Duchanoy,Lina E. Fortelius,Sebastian K.-J. Landor,Diana M. Toivola,Mika Lindén,Cecilia Sahlgren +10 more
TL;DR: A novel approach, using imagable mesoporous silica nanoparticles (MSNPs) as vehicles for targeted delivery of GSIs to block Notch signaling is presented, highlighting MSNPs as an attractive platform for targeted drug delivery of anticancer drugs with otherwise restricted clinical application.
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MSN-Mediated Sequential Vascular-to-Cell Nuclear-Targeted Drug Delivery for Efficient Tumor Regression
TL;DR: Mesoporous silica nanoparticles functionalized with peptides are developed for sequential drug delivery and a tumor in a murine xenograft model is successfully regressed.
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Colloidal HPMO nanoparticles: silica-etching chemistry tailoring, topological transformation, and nano-biomedical applications.
Yu Chen,Pengfei Xu,Hangrong Chen,Yongsheng Li,Wenbo Bu,Zhu Shu,Yaping Li,Jiamin Zhang,Lingxia Zhang,Limin Pan,Xiangzhi Cui,Zile Hua,Jin Wang,Linlin Zhang,Jianlin Shi +14 more
TL;DR: Colloidal hollow periodic mesoporous organosilica nanoparticles with tunable compositions and highly hybridized nanostructures are successfully synthesized by a simple, easily scale-up but versatile silica-etching chemistry (alkaline or HF etching) for their applications in nano-fabrication and nano-medicine.