Journal ArticleDOI
Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality.
TLDR
This research provides a paradigm that framework organic-inorganic hybridization can endow the inorganic nanocarrier with unique biological effects suitable for biomedical application, benefiting the development of novel nanosystems with the unique bio-functionality and performance.About:
This article is published in Biomaterials.The article was published on 2017-05-01. It has received 166 citations till now. The article focuses on the topics: Mesoporous organosilica & Mesoporous silica.read more
Citations
More filters
Journal ArticleDOI
Interface-engineered paclitaxel-based hollow mesoporous organosilica nanoplatforms for photothermal-enhanced chemotherapy of tumor
Chunxi Qian,Bandar Al-Hamyari,Xiaofei Tang,Bo Hou,Shuaibo Yang,Guifang Zhang,Huijuan Lv,Zhigang Yang,Zhaohui Wang,Yanbin Shi +9 more
TL;DR: In this article, an engineered, a biodegradable hollow mesoporous organosilica nanoparticle (HMON)-based nanoplatform was fabricated for photothermalenhanced chemotherapy of tumor.
Journal ArticleDOI
Development of Amino Acids Functionalized SBA-15 for the Improvement of Protein Adsorption
Raquel Gutiérrez-Climente,Margaux Clavié,Jérémie Gouyon,Giang Ngo,Yoann Ladner,Pascal Etienne,Pascal Dumy,Pierre Martineau,Martine Pugnière,Catherine Perrin,Gilles Subra,Ahmad Mehdi +11 more
TL;DR: In this article, silylated amino acid derivatives (Si-AA-NH2) have been immobilized onto SBA-15 materials in biocompatible conditions avoiding the use of toxic catalyst, solvents or reagents.
Journal ArticleDOI
A novel pH- and glutathione-responsive drug delivery system based on in situ growth of MOF199 on mesoporous organic silica nanoparticles targeting the hepatocellular carcinoma niche
Jiaji Ling,Yongmei Jiang,Shaoying Yan,Hao Dang,Huan Yue,Kanglin Liu,Linghan Kuang,Xingxin Liu,Hua Tang +8 more
TL;DR: In this article , a degradable nanocomposite (D/S@SPMM) was constructed for hepatocellular carcinoma (HCC) targeting and long-lasting accumulation properties at the tumor region.
Journal ArticleDOI
Self-transformation synthesis of hierarchically porous benzene-bridged organosilica nanoparticles for efficient drug delivery.
C. Nithyanandam,Jun Tao,Zhihao Feng,Jiajia Zhao,Muhammad Rizwan Younis,Wei Lu,Dong Chen,Lixing Weng,Xiaodan Su,Zhaogang Teng,Lianhui Wang +10 more
TL;DR: In this paper, a feasible outside-in hydrothermal self-transformation strategy is presented to fabricate hierarchically porous benzene-bridged organosilica nanoparticles (HPBONs).
Journal ArticleDOI
Self-transformation synthesis of hierarchically porous benzene-bridged organosilica nanoparticles for efficient drug delivery
TL;DR: In this paper , a feasible outside-in hydrothermal self-transformation strategy is presented to fabricate hierarchically porous benzene-bridged organosilica nanoparticles (HPBONs).
References
More filters
Journal ArticleDOI
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Martin Lundqvist,Johannes Stigler,Giuliano Elia,Iseult Lynch,Tommy Cedervall,Kenneth A. Dawson +5 more
TL;DR: The long-lived (“hard”) protein corona formed from human plasma is studied for a range of nanoparticles that differ in surface properties and size and both size and surface properties were found to play a very significant role.
Journal ArticleDOI
Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
TL;DR: This review highlights the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers and envision that these MSN-based systems have a great potential for a variety of drug delivery applications.
Journal ArticleDOI
Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
TL;DR: The in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure.
Journal ArticleDOI
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Horacio Cabral,Yu Matsumoto,Kazue Mizuno,Qixian Chen,Mami Murakami,M. Kimura,Yasuko Terada,Mitsunobu R. Kano,Kohei Miyazono,Mitsuru Uesaka,Nobuhiro Nishiyama,Kazunori Kataoka +11 more
TL;DR: It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours.
Journal ArticleDOI
Demonstration of a spaser-based nanolaser
Mikhail A. Noginov,Guohua Zhu,A. M. Belgrave,Reuben M. Bakker,Vladimir M. Shalaev,Evgenii E. Narimanov,S Stout,S Stout,Erik Herz,Teeraporn Suteewong,Ulrich Wiesner +10 more
TL;DR: It is shown that 44-nm-diameter nanoparticles with a gold core and dye-doped silica shell allow us to completely overcome the loss of localized surface plasmons by gain and realize a spaser, and that outcoupling of surface plasmon oscillations to photonic modes at a wavelength of 531 nm makes this system the smallest nanolaser reported to date—and to the authors' knowledge the first operating at visible wavelengths.