Journal ArticleDOI
Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality.
TLDR
This research provides a paradigm that framework organic-inorganic hybridization can endow the inorganic nanocarrier with unique biological effects suitable for biomedical application, benefiting the development of novel nanosystems with the unique bio-functionality and performance.About:
This article is published in Biomaterials.The article was published on 2017-05-01. It has received 166 citations till now. The article focuses on the topics: Mesoporous organosilica & Mesoporous silica.read more
Citations
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Surfactant-free synthesis of monodispersed organosilica particles with pure sulfide-bridged silsesquioxane framework chemistry via extension of Stöber method
TL;DR: By extending the classic Stöber method, a surfactant-free synthesis of monodispersed organosilica particles with pure sulfide-bridged silsesquioxane framework chemistry is reported for the first time and both hydrophilic and hydrophobic molecules can be in-situ encapsulated into tetra-sulfide bridged silica nanoparticles, whose glutathione-triggered biodegradability is demonstrated.
Journal ArticleDOI
Controlled PEGylation of periodic mesoporous organosilica nanospheres for improving their stability in physiological solutions
TL;DR: In this paper, thioether-bridged PMO nanospheres were modified with different molecular weighted polyethylene glycol (PEG) via click reaction for the first time and FI-IR and thermogravimetric analysis confirm the successful modification of PEG on the PMO.
Journal ArticleDOI
Polymer/silica hybrid hollow nanoparticles with channels and thermo-responsive gatekeepers for drug storage and release
Chenglin Wu,Xia Chen,Zhicai He +2 more
TL;DR: In this paper, polymer/silica hybrid hollow nanoparticles (PSHNs) with channels and thermo-responsive gatekeepers for drug storage and on-off release were successfully synthesized using core-shell polymeric micelles of poly(N-isopropylacrylamide)-b-poly(4-vinylpyridine) (PNIPAM-b-P4VP) as a template.
Journal ArticleDOI
Emerging Strategies in Anticancer Combination Therapy Employing Silica-Based Nanosystems.
TL;DR: The focus is on self‐triggered strategies able to improve the therapeutic effect of drug delivery nanosystems able to achieve complete tumor remission in murine models.
References
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Journal ArticleDOI
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Martin Lundqvist,Johannes Stigler,Giuliano Elia,Iseult Lynch,Tommy Cedervall,Kenneth A. Dawson +5 more
TL;DR: The long-lived (“hard”) protein corona formed from human plasma is studied for a range of nanoparticles that differ in surface properties and size and both size and surface properties were found to play a very significant role.
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Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
TL;DR: This review highlights the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers and envision that these MSN-based systems have a great potential for a variety of drug delivery applications.
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Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
TL;DR: The in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure.
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Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Horacio Cabral,Yu Matsumoto,Kazue Mizuno,Qixian Chen,Mami Murakami,M. Kimura,Yasuko Terada,Mitsunobu R. Kano,Kohei Miyazono,Mitsuru Uesaka,Nobuhiro Nishiyama,Kazunori Kataoka +11 more
TL;DR: It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours.
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Demonstration of a spaser-based nanolaser
Mikhail A. Noginov,Guohua Zhu,A. M. Belgrave,Reuben M. Bakker,Vladimir M. Shalaev,Evgenii E. Narimanov,S Stout,S Stout,Erik Herz,Teeraporn Suteewong,Ulrich Wiesner +10 more
TL;DR: It is shown that 44-nm-diameter nanoparticles with a gold core and dye-doped silica shell allow us to completely overcome the loss of localized surface plasmons by gain and realize a spaser, and that outcoupling of surface plasmon oscillations to photonic modes at a wavelength of 531 nm makes this system the smallest nanolaser reported to date—and to the authors' knowledge the first operating at visible wavelengths.