Journal ArticleDOI
Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality.
TLDR
This research provides a paradigm that framework organic-inorganic hybridization can endow the inorganic nanocarrier with unique biological effects suitable for biomedical application, benefiting the development of novel nanosystems with the unique bio-functionality and performance.About:
This article is published in Biomaterials.The article was published on 2017-05-01. It has received 166 citations till now. The article focuses on the topics: Mesoporous organosilica & Mesoporous silica.read more
Citations
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Journal ArticleDOI
Iron-engineered mesoporous silica nanocatalyst with biodegradable and catalytic framework for tumor-specific therapy.
TL;DR: This work paves a promising way to engineer the inert framework of MSN into functional, biodegradable and catalytic nanoplatform, featuring effective tumor-therapeutic outcome and stimuli-responsive biodegradation concurrently.
Journal ArticleDOI
Synergistic Sonodynamic/Chemotherapeutic Suppression of Hepatocellular Carcinoma by Targeted Biodegradable Mesoporous Nanosonosensitizers
TL;DR: A synergistic inhibition effect of drug‐loaded HMONs‐PpIX‐arginine‐glycine‐aspartic acid on HCC growth has been systematically demonstrated both in vitro and in vivo (84.7% inhibition rate), which brings insights and meets the versatile therapeutic requirements for HCC management.
Journal ArticleDOI
Functionalized mesoporous silica nanoparticles and biomedical applications.
Thai Thanh Hoang Thi,Van Du Cao,Thi Nhu Quynh Nguyen,Duc Thuan Hoang,Van Cuong Ngo,Dai Hai Nguyen +5 more
TL;DR: This review focuses on discussion the recent fabrication of functionalized MSNs and their potential applications in drug delivery, therapeutic treatments, diagnostic imaging, and biocatalyst.
Journal ArticleDOI
Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery.
TL;DR: The facile and large-scale fabrication of monodispersed and molecularly organic-inorganic hybrid MONs with framework-incorporated physiologically active thioether bonds, controllable nanostructure, composition and morphology provides the material foundation for exploring the versatile biomedical applications of organosilica nanosystems.
Journal ArticleDOI
Nanotransducers for Near-Infrared Photoregulation in Biomedicine.
TL;DR: The emerging applications, including photoregulation of neural activity, gene expression, and visual systems, as well as photochemical tissue bonding, are highlighted, along with the design principles of nanotransducers.
References
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Journal ArticleDOI
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Martin Lundqvist,Johannes Stigler,Giuliano Elia,Iseult Lynch,Tommy Cedervall,Kenneth A. Dawson +5 more
TL;DR: The long-lived (“hard”) protein corona formed from human plasma is studied for a range of nanoparticles that differ in surface properties and size and both size and surface properties were found to play a very significant role.
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Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
TL;DR: This review highlights the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers and envision that these MSN-based systems have a great potential for a variety of drug delivery applications.
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Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
TL;DR: The in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure.
Journal ArticleDOI
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Horacio Cabral,Yu Matsumoto,Kazue Mizuno,Qixian Chen,Mami Murakami,M. Kimura,Yasuko Terada,Mitsunobu R. Kano,Kohei Miyazono,Mitsuru Uesaka,Nobuhiro Nishiyama,Kazunori Kataoka +11 more
TL;DR: It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours.
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Demonstration of a spaser-based nanolaser
Mikhail A. Noginov,Guohua Zhu,A. M. Belgrave,Reuben M. Bakker,Vladimir M. Shalaev,Evgenii E. Narimanov,S Stout,S Stout,Erik Herz,Teeraporn Suteewong,Ulrich Wiesner +10 more
TL;DR: It is shown that 44-nm-diameter nanoparticles with a gold core and dye-doped silica shell allow us to completely overcome the loss of localized surface plasmons by gain and realize a spaser, and that outcoupling of surface plasmon oscillations to photonic modes at a wavelength of 531 nm makes this system the smallest nanolaser reported to date—and to the authors' knowledge the first operating at visible wavelengths.