Journal ArticleDOI
Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality.
TLDR
This research provides a paradigm that framework organic-inorganic hybridization can endow the inorganic nanocarrier with unique biological effects suitable for biomedical application, benefiting the development of novel nanosystems with the unique bio-functionality and performance.About:
This article is published in Biomaterials.The article was published on 2017-05-01. It has received 166 citations till now. The article focuses on the topics: Mesoporous organosilica & Mesoporous silica.read more
Citations
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Journal ArticleDOI
Chitosan capped pH-responsive hollow mesoporous silica nanoparticles for targeted chemo-photo combination therapy.
TL;DR: A biodegradable pH-responsive hollow mesoporous silica nanoparticle was developed for co-delivery of pheophorbide a and doxorubicin and showed excellent drug controlled release properties based on the pH-dependent swelling effect of the coating layer.
Journal ArticleDOI
Fabrication of a hyaluronic acid conjugated metal organic framework for targeted drug delivery and magnetic resonance imaging
TL;DR: The constructed ZIF-8 based multifunctional nanocarrier could be a candidate for cancer theranostics and the chelation of Fe3+ by PDA makes the prepared DOX@ZIF-HA a good contrast agent for magnetic resonance (MR) imaging.
Journal ArticleDOI
Mesoporous silica nanoparticles for tissue-engineering applications
TL;DR: In this review, the recent advances in the tissue-engineering application of Mesoporous silica nanoparticles are summarized and the controlled synthesis of MSNs is delineated first in terms of tuning the morphology, pore size, and its surface chemistry, as well as biodegradability.
Journal ArticleDOI
Sustained delivery of siRNA/mesoporous silica nanoparticle complexes from nanofiber scaffolds for long-term gene silencing.
TL;DR: The feasibility and the efficacy of siRNA/MSN delivered from electrospun scaffolds through surface adsorption and nanofiber encapsulation is shown and it is shown that this method enhances siRNA transfection efficiency and sustained targeted proteins silencing in vitro and in vivo.
Journal ArticleDOI
Chemodrug-Gated Biodegradable Hollow Mesoporous Organosilica Nanotheranostics for Multimodal Imaging-Guided Low-Temperature Photothermal Therapy/Chemotherapy of Cancer
TL;DR: This research provides a paradigm that has a chemodrug-gated HMONs-based theranostic nanoplatform with intrinsic biodegradability, multimodal imaging capacity, high low-temperature PTT/chemotherapy efficacy, and reduced systemic toxicity.
References
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Journal ArticleDOI
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Martin Lundqvist,Johannes Stigler,Giuliano Elia,Iseult Lynch,Tommy Cedervall,Kenneth A. Dawson +5 more
TL;DR: The long-lived (“hard”) protein corona formed from human plasma is studied for a range of nanoparticles that differ in surface properties and size and both size and surface properties were found to play a very significant role.
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Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
TL;DR: This review highlights the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers and envision that these MSN-based systems have a great potential for a variety of drug delivery applications.
Journal ArticleDOI
Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
TL;DR: The in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure.
Journal ArticleDOI
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Horacio Cabral,Yu Matsumoto,Kazue Mizuno,Qixian Chen,Mami Murakami,M. Kimura,Yasuko Terada,Mitsunobu R. Kano,Kohei Miyazono,Mitsuru Uesaka,Nobuhiro Nishiyama,Kazunori Kataoka +11 more
TL;DR: It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours.
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Demonstration of a spaser-based nanolaser
Mikhail A. Noginov,Guohua Zhu,A. M. Belgrave,Reuben M. Bakker,Vladimir M. Shalaev,Evgenii E. Narimanov,S Stout,S Stout,Erik Herz,Teeraporn Suteewong,Ulrich Wiesner +10 more
TL;DR: It is shown that 44-nm-diameter nanoparticles with a gold core and dye-doped silica shell allow us to completely overcome the loss of localized surface plasmons by gain and realize a spaser, and that outcoupling of surface plasmon oscillations to photonic modes at a wavelength of 531 nm makes this system the smallest nanolaser reported to date—and to the authors' knowledge the first operating at visible wavelengths.