Journal ArticleDOI
Synthesis and Biomedical Applications of Multifunctional Nanoparticles
TLDR
Various components to construct the multifunctional NP agents, which include polymers and mesoporous, magnetic, catalytic, and semiconducting NPs, are discussed together with their overall integration forms, such as NP assembly, hollow/porous structures, or hybrid/doped systems.Abstract:
The accumulated knowledge of nanoparticle (NP) synthesis for the last 30 years has enabled the development of functional NPs for biomedical applications. Especially, NPs with multifunctional capabilities are gaining popularity as the demand for versatile and efficient NP agents increases. Various combinations of functional materials are integrated to form multicomponent NPs with designed size, structure, and multifunctionality. Their use as diagnostic and/or therapeutic tools is demonstrated, suggesting their application potentials in healthcare and medical practice. Here, the recent achievements in the synthesis and biomedical applications of multifunctional NPs are summarized. Starting with a brief overview regarding the advances in NP synthesis and accompanying progress in nanobiotechnology, various components to construct the multifunctional NP agents, which include polymers and mesoporous, magnetic, catalytic, and semiconducting NPs, are discussed together with their overall integration forms, such as NP assembly, hollow/porous structures, or hybrid/doped systems. Following the explanation of the features that multifunctional NP agents can offer, an outlook and a brief comment regarding the future research directions are provided.read more
Citations
More filters
Journal ArticleDOI
Matching the kinetics of natural enzymes with a single-atom iron nanozyme
Shufang Ji,Bing Jiang,Haigang Hao,Yuanjun Chen,Juncai Dong,Yu Mao,Zedong Zhang,Rui Gao,Wenxing Chen,Ruofei Zhang,Qian Liang,Haijing Li,Shuhu Liu,Yu Wang,Qinghua Zhang,Lin Gu,Demin Duan,Minmin Liang,Dingsheng Wang,Xiyun Yan,Yadong Li +20 more
TL;DR: In this paper, an engineered FeN3P-centred single-atom nanozyme (FeN 3P-SAzyme) was developed that exhibits comparable peroxidase-like catalytic activity and kinetics to natural enzymes, by controlling the electronic structure of the single atom active center through the precise coordination of phosphorus and nitrogen.
Journal ArticleDOI
Magnetic Nanoparticles in Cancer Therapy and Diagnosis.
Ali Farzin,Ali Farzin,S. A. Etesami,Jacob Quint,Adnan Memic,Adnan Memic,Ali Tamayol,Ali Tamayol,Ali Tamayol +8 more
TL;DR: This review discusses methods utilized for the fabrication and engineering of MNPs, and challenges in the field and potential opportunities for the use ofMNPs toward improving their properties are discussed.
Journal ArticleDOI
Biomimetic Nanotherapies: Red Blood Cell Based Core-Shell Structured Nanocomplexes for Atherosclerosis Management.
Yi Wang,Kang Zhang,Xian Qin,Tianhan Li,Juhui Qiu,Tieying Yin,Junli Huang,Sean McGinty,Giuseppe Pontrelli,Jun Ren,Qiwei Wang,Wei Wu,Guixue Wang +12 more
TL;DR: This study demonstrates the therapeutic advantages of biomimetic nanotherapy for Atherosclerosis treatment, which holds considerable promise as a new generation of drug delivery system for safe and efficient management of atherosclerosis.
Journal ArticleDOI
Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications.
Yi Wang,Kang Zhang,Tianhan Li,Ali Maruf,Xian Qin,Li Luo,Yuan Zhong,Juhui Qiu,Sean McGinty,Giuseppe Pontrelli,Xiaoling Liao,Wei Wu,Guixue Wang +12 more
TL;DR: It is demonstrated that MM/RAPNPs could efficiently and safely inhibit the progression of AS and may be potential drug delivery systems for safe and effective anti-AS applications.
Journal ArticleDOI
Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging
W. Russ Algar,Melissa Massey,Kelly Rees,Rehan Higgins,Katherine D Krause,Ghinwa H. Darwish,William J. Peveler,Zhujun Xiao,Hsin-Yun Tsai,Rupsa Gupta,Kelsi Lix,Michael V. Tran,Hyungki Kim +12 more
TL;DR: This review provides a comprehensive and heuristic overview of luminescent nanoparticles, targeted to both newcomers and experts who are interested in a critical assessment of LNP materials, their properties, strengths and weaknesses, and prospective applications.
References
More filters
Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Nanostructured materials for advanced energy conversion and storage devices
Antonino S. Aricò,Peter G. Bruce,Bruno Scrosati,Jean-Marie Tarascon,Jean-Marie Tarascon,Walter van Schalkwijk +5 more
TL;DR: This review describes some recent developments in the discovery of nanoelectrolytes and nanoeLECTrodes for lithium batteries, fuel cells and supercapacitors and the advantages and disadvantages of the nanoscale in materials design for such devices.
Journal ArticleDOI
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
Journal ArticleDOI
A DNA-based Method for Rationally Assembling Nanoparticles Into Macroscopic Materials
TL;DR: A method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition is described.
Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Related Papers (5)
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Hui Wei,Erkang Wang +1 more