Journal ArticleDOI
Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality.
TLDR
This research provides a paradigm that framework organic-inorganic hybridization can endow the inorganic nanocarrier with unique biological effects suitable for biomedical application, benefiting the development of novel nanosystems with the unique bio-functionality and performance.About:
This article is published in Biomaterials.The article was published on 2017-05-01. It has received 166 citations till now. The article focuses on the topics: Mesoporous organosilica & Mesoporous silica.read more
Citations
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Journal ArticleDOI
Nanoarchitecting Hierarchical Mesoporous Siliceous Frameworks: A New Way Forward.
TL;DR: This review gives a brief emphasis on re-engineering such stable siliceous frameworks through modifying their intrinsic structural and physicochemical attributes, resulting in the hetero-nanostructures of irregular-shaped (Janus and multi-podal) and dynamically-modulated (deformable solids) architectures with high morphological complexity.
Journal ArticleDOI
In Vivo Assembly and Disassembly of Probes to Improve Near‐Infrared Optical Bioimaging
TL;DR: An overview of in vivo assembly and disassembly strategies to improve tumor‐specific accumulation, “turn‐on” the silent signals, and reduce the background noise in NIR bioimaging windows is provided.
Journal ArticleDOI
Acid‐Degradable Hydrogen‐Generating Metal‐Organic Framework for Overcoming Cancer Resistance/Metastasis and Off‐Target Side Effects
TL;DR: In this article , a new type of porphyrin-iron metal organic framework (Fe-MOF) nanocrystals is engineered as acid-degradable drug carrier and hydrogen donor by the coordination between porphrin and zero-valence Fe atom.
Journal ArticleDOI
Size effect of mesoporous organosilica nanoparticles on tumor penetration and accumulation
Junjie Zhang,Xiaofen Wang,Jun Wen,Xiaodan Su,Lixing Weng,Chunyan Wang,Ying Tian,Yunlei Zhang,Jun Tao,Peng Xu,Guangming Lu,Zhaogang Teng,Zhaogang Teng,Lianhui Wang +13 more
TL;DR: In vivo experiments show that the 40 nm MONs possess the longest mean residence times, leading to their highest accumulation in blood and tumors, and this work provides an important guideline for the rational design of nanoplatforms for tumor treatment.
Journal ArticleDOI
Biodegradable Periodic Mesoporous Organosilica (BPMO) Loaded with Daunorubicin: A Promising Nanoparticle-Based Anticancer Drug
Ngoc Xuan Dat Mai,Albane Birault,Kotaro Matsumoto,Hanh Kieu Thi Ta,Soontaree Grace Intasa-Ard,Kendall Morrison,Phan Bach Thang,Tan Le Hoang Doan,Fuyuhiko Tamanoi +8 more
TL;DR: DNR‐loaded BPMO represents a promising nanodrug compared with free DNR currently used in cancer therapy, and lack of adverse effect on organs such as lung appears to be due to excellent tumor accumulation of B PMO.
References
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Journal ArticleDOI
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Martin Lundqvist,Johannes Stigler,Giuliano Elia,Iseult Lynch,Tommy Cedervall,Kenneth A. Dawson +5 more
TL;DR: The long-lived (“hard”) protein corona formed from human plasma is studied for a range of nanoparticles that differ in surface properties and size and both size and surface properties were found to play a very significant role.
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Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
TL;DR: This review highlights the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers and envision that these MSN-based systems have a great potential for a variety of drug delivery applications.
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Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
TL;DR: The in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure.
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Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Horacio Cabral,Yu Matsumoto,Kazue Mizuno,Qixian Chen,Mami Murakami,M. Kimura,Yasuko Terada,Mitsunobu R. Kano,Kohei Miyazono,Mitsuru Uesaka,Nobuhiro Nishiyama,Kazunori Kataoka +11 more
TL;DR: It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours.
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Demonstration of a spaser-based nanolaser
Mikhail A. Noginov,Guohua Zhu,A. M. Belgrave,Reuben M. Bakker,Vladimir M. Shalaev,Evgenii E. Narimanov,S Stout,S Stout,Erik Herz,Teeraporn Suteewong,Ulrich Wiesner +10 more
TL;DR: It is shown that 44-nm-diameter nanoparticles with a gold core and dye-doped silica shell allow us to completely overcome the loss of localized surface plasmons by gain and realize a spaser, and that outcoupling of surface plasmon oscillations to photonic modes at a wavelength of 531 nm makes this system the smallest nanolaser reported to date—and to the authors' knowledge the first operating at visible wavelengths.