Journal ArticleDOI
Mucin-1 conjugated polyamidoamine-based nanoparticles for image-guided delivery of gefitinib to breast cancer
Poorya Najjari Nabi,Nasim Vahidfar,Mohammad Reza Tohidkia,Aliasghar Hamidi,Yadollah Omidi,Ayuob Aghanejad +5 more
TLDR
In this paper, the authors examined the impact of mucin-1 aptamer-conjugated NPs which were engineered using PAM for image-guided delivery of gefitinib (GEF) in the breast cancer cells/tumor.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2021-03-31. It has received 31 citations till now.read more
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Recombinant mucin biotechnology and engineering.
TL;DR: Mucins represent a largely untapped class of polymeric building blocks for biomaterials, therapeutics, and other biotechnology as mentioned in this paper , and the opportunities for engineered mucins in biomedical applications ranging from in vitro models to therapeutics.
Journal ArticleDOI
Review of the Delivery Kinetics of Thermosensitive Liposomes
TL;DR: In this article , the authors provide guidelines on how to improve drug delivery with TSL by optimizing the combination of TSL, drug, and hyperthermia method, and discuss the benefits of selecting a drug with rapid extraction by tissue, and with quick cellular uptake.
Journal ArticleDOI
Theranostic chimeric antigen receptor (CAR)-T cells: Insight into recent trends and challenges in solid tumors.
Keyvan Kheyrolahzadeh,Mohammad Reza Tohidkia,Ali Tarighatnia,Parviz Shahabi,Nader D. Nader,Ayuob Aghanejad +5 more
TL;DR: In this article , the authors discuss the main obstacles, mechanism of action, novel strategies and solutions to overcome the challenges from molecular imaging and cell tracking perspectives to effectively deliver CAR-T cells into solid tumors.
Journal ArticleDOI
Design and synthesis of Ag NPs/chitosan-starch nano-biocomposite as a modern anti-human malignant melanoma drug.
TL;DR: In this article , the biogenic nanoarchitechtonics of Ag NPs template over chitosan/starch mixed hydrogel have notable reducing potential and anti-malignant melanoma effects.
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Targeted therapy for HCC using dumbbell-like nanoparticles conjugated to monoclonal antibodies against VEGF and cancer stem cell receptors in mice
Wafaa Mansour,Shahira Fathy El Fedawy,Shimaa Atta,Rewan Mohsen Zarie,Nermeen T. Aly Fouad,S. Maher,Taghreed Hussein,D. M. Abdel Aziz,Manal Kamel +8 more
TL;DR: In this article , a study aimed to assess the therapeutic role of dumbbell-like nanoparticles conjugated with monoclonal antibodies (mAbs) against both vascular endothelial growth factor (VEGF) and cluster of differentiation (CD) 90 (a cancer stem cell marker) in hepatocellular carcinoma experimental model.
References
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray,Jacques Ferlay,Isabelle Soerjomataram,Rebecca L. Siegel,Lindsey A. Torre,Ahmedin Jemal +5 more
TL;DR: A status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions.
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TL;DR: A further understanding of the system is required to develop an effective anticancer regimen and a combination therapy that comprises an anti-EGFR and a chemotherapeutic/chemopreventive agent will exhibit a multi-pronged approach that can be developed into a highly attractive and specific molecular oriented remedy.
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Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity
Xiaoying Yang,Yinsong Wang,Xin Huang,Yanfeng Ma,Yi Huang,Rongcun Yang,Hongquan Duan,Yongsheng Chen +7 more
TL;DR: The results show that this multi-functionalized GO has potential applications for targeted delivery and the controlled release of anticancer drugs.
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Clinical toxicities of nanocarrier systems.
Karina R. Vega-Villa,Jody K. Takemoto,Jaime A. Yáñez,Connie M. Remsberg,M. Laird Forrest,Neal M. Davies +5 more
TL;DR: Nanocarrier may alter the physicochemical properties of xenobiotics resulting in pharmaceutical changes in stability, solubility, and pharmacokinetic disposition, and in particular, nanocarriers may reduce toxicity of hydrophobic cancer drugs that are solubilized.
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Recent Advances in the Treatment of Breast Cancer
TL;DR: The heterogeneity of T NBC is discussed and how molecular subtyping of TNBC may help drug discovery for this deadly disease.