scispace - formally typeset
Open AccessJournal ArticleDOI

Nanoparticles containing insoluble drug for cancer therapy.

Shutao Guo, +1 more
- 01 Jul 2014 - 
- Vol. 32, Iss: 4, pp 778-788
Reads0
Chats0
TLDR
The unique advantages and disadvantages of polymeric nanoparticles, liposomes, solid lipid nanoparticles and lipid-coated nanoparticles for targeted drug delivery will be investigated in detail.
About: 
This article is published in Biotechnology Advances.The article was published on 2014-07-01 and is currently open access. It has received 128 citations till now. The article focuses on the topics: Targeted drug delivery & Drug delivery.

read more

Citations
More filters
Journal ArticleDOI

Recent advances of cocktail chemotherapy by combination drug delivery systems.

Quanyin Hu, +3 more
- 01 Mar 2016 - 
TL;DR: This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers and highlights the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems.
Journal ArticleDOI

Recent applications of PLGA based nanostructures in drug delivery

Maria Mir, +2 more
- 01 Nov 2017 - 
TL;DR: This review focuses on fabrication techniques of PLGA based nanostructures and their advanced biomedical applications covering drug delivery and in-vivo imaging.
Journal ArticleDOI

Strategies to improve micelle stability for drug delivery

Yang Lu, +3 more
- 01 Aug 2018 - 
TL;DR: Different strategies including crosslinking and non-crosslinking approaches designed to stabilize micelles are reviewed and perspectives on future research directions are offered.
Journal ArticleDOI

Targeted drug delivery strategies for precision medicines

Mandana T. Manzari, +9 more
- 02 Feb 2021 - 
TL;DR: This Review investigates the integration of targeted drugs, in particular, kinase inhibitors, with targeted drug delivery systems and identifies opportunities for strategies to improve the therapeutic index of cancer drugs and, consequently, clinical outcomes.
Journal ArticleDOI

Biomacromolecules as carriers in drug delivery and tissue engineering.

Yujie Zhang, +2 more
- 09 Dec 2017 - 
TL;DR: This review gives a brief introduction to the biochemical properties of the widely used biomacromolecule-based carriers such as albumin, lipoproteins and polysaccharides and the current challenges and future prospects of present biological carriers are discussed.
References
More filters
Journal ArticleDOI

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.

Hiroshi Maeda, +4 more
- 01 Mar 2000 - 
TL;DR: The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.
Journal ArticleDOI

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

Ting-Chao Chou
- 15 Jan 2010 - 
TL;DR: This brief perspective article focuses on the most common errors and pitfalls, as well as the do's and don'ts in drug combination studies, in terms of experimental design, data acquisition, data interpretation, and computerized simulation.
Journal ArticleDOI

Cancer nanotechnology: opportunities and challenges.

Mauro Ferrari
- 01 Mar 2005 - 
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
Journal ArticleDOI

Fibroblasts in cancer

Raghu Kalluri, +3 more
- 01 May 2006 - 
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
Journal ArticleDOI

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

Hirenkumar K. Makadia, +1 more
- 01 Sep 2011 - 
TL;DR: This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release.
Related Papers (5)

Biodegradable polymeric nanoparticles based drug delivery systems

Avnesh Kumari, +2 more
- 01 Jan 2010 - 

Nanoparticle therapeutics: an emerging treatment modality for cancer

Mark E. Davis, +2 more
- 01 Sep 2008 - 

Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles

Donald E. Owens, +1 more
- 03 Jan 2006 - 

Strategies in the design of nanoparticles for therapeutic applications

Robby A. Petros, +2 more
- 01 Aug 2010 - 

Nanocarriers as an emerging platform for cancer therapy

Dan Peer, +6 more
- 01 Dec 2007 - 
Frequently Asked Questions (1)
Q1. What are the contributions in "Nanoparticles containing insoluble drug for cancer therapy" ?

By mechanisms of the enhanced permeability and retention effect, nanoparticle drug formulations are capable of greatly enhancing the safety, pharmacokinetic profiles and bioavailability of the administered treatment. Here, the progress of various nanoparticle formulations in both research and clinical applications is detailed with a focus on the development of drug/gene delivery systems. Specifically, the unique advantages and disadvanges of polymeric nanoparticles, liposomes, solid lipid nanoparticles, nanocrystals and lipid-coated nanoparticles for targeted drug delivery will be investigated in detail.