Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery.
TLDR
The transport mechanism of the GI tract, barriers to protein absorption, current status and limitations of nanotechnology for oral protein delivery system are reviewed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-06-15 and is currently open access. It has received 360 citations till now. The article focuses on the topics: Targeted drug delivery & Membrane permeability.read more
Citations
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Approaches for Enhancing Oral Bioavailability of Peptides and Proteins
TL;DR: The physiological barriers to oral delivery of peptides and proteins and novel pharmaceutical approaches to circumvent these barriers and enhance oral bioavailability of these macromolecules are summarized.
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Role of nanoparticle size, shape and surface chemistry in oral drug delivery.
TL;DR: Understanding the role of nanoparticle geometry in intestinal uptake and transport will bring forth a paradigm shift in nanoparticle engineering for oral delivery and non-spherical nanoparticles should be further investigated and considered for Oral delivery of therapeutic drugs and diagnostic materials.
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From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity.
TL;DR: The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control, and the varying mechanisms of lymphatic entry and transport are summarized, as well as discussing examples ofymphatic delivery that have enhanced therapeutic utility.
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A holistic approach to targeting disease with polymeric nanoparticles
TL;DR: This Opinion article outlines a holistic view of nanoparticle targeting, in which the route of administration, molecular characteristics and temporal control of the nanoparticles are potential design variables that must be considered simultaneously.
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Non-invasive delivery strategies for biologics.
TL;DR: This Review summarizes the current status, latest updates and future prospects for delivery of peptides, proteins and other biologics, including subcutaneous, transdermal, oral, inhalation, nasal and buccal routes.
References
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Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Ajay Kumar Gupta,Mona Gupta +1 more
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New perspectives in cell adhesion : RGD and integrins
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TL;DR: As the integrin-mediated cell attachment influences and regulates cell migration, growth, differentiation, and apoptosis, the RGD peptides and mimics can be used to probe integrin functions in various biological systems.
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RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
TL;DR: The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed.