Natural Products in Cancer Therapy: Past, Present and Future.
Min Huang,Jin-Jian Lu,Jian Ding +2 more
TLDR
This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches, new pharmacological models, and exploration of emerging directions to revitalize natural products search in cancer therapy.Abstract:
Natural products, with remarkable chemical diversity, have been extensively investigated for their anticancer potential for more than a half-century. The collective efforts of the community have achieved the tremendous advancements, bringing natural products to clinical use and discovering new therapeutic opportunities, yet the challenges remain ahead. With remarkable changes in the landscape of cancer therapy and growing role of cutting-edge technologies, we may have come to a crossroads to revisit the strategies to understand nature products and to explore their therapeutic utility. This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches, new pharmacological models, and exploration of emerging directions to revitalize natural products search in cancer therapy.read more
Citations
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New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
Yuyu Zhu,Zijun Ouyang,Haojie Du,Mei Jing Wang,Jiaojiao Wang,Haiyan Sun,Ling-dong Kong,Qiang Xu,Hongyue Ma,Yang Sun +9 more
TL;DR: Wang et al. as mentioned in this paper reviewed the molecular mechanisms of action of natural products from different sources used in the treatment of inflammatory diseases and cancer, introducing the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients.
Journal ArticleDOI
Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review
Md.Ferdaus Alam Sohel,Habiba Sultana,Tayeba Sultana,Mohammad Al Amin,Suraiya Aktar,Md. Chayan Ali,Zahed Bin Rahim,Md. Arju Hossain,Abdullah Al Mamun,Mohammad Nurul Amin,Raju Dash +10 more
TL;DR: Hesperetin (HSP) is a phytoestrogen present in citrus fruits in a high concentration (several hundred mg/kg) and exhibited anti-cancer activities through interfering at several pathways as discussed by the authors .
Journal ArticleDOI
Development of natural products for anti-PD-1/PD-L1 immunotherapy against cancer.
Myong Hak Ri,Juan Ma,Xuejun Jin +2 more
TL;DR: In this article, the authors summarize natural products, raw extracts, and traditional medicines with pharmacological effects associated with the PD-1/PD-L1 axis, particularly PD-L 1.
Journal ArticleDOI
Genistein, a Potential Phytochemical against Breast Cancer Treatment-Insight into the Molecular Mechanisms
Md.Ferdaus Alam Sohel,Partha Biswas,Mohammad Al Amin,Md. Arju Hossain,Habiba Sultana,Dipta Dey,Suraiya Aktar,Arifa Setu,Md. Sharif Khan,Priya Paul,Md. Nurul Islam,Md. Ataur Rahman,Bonglee Kim,Abdullah Al Mamun +13 more
TL;DR: This review discusses several molecular interactions of GNT with numerous cellular targets in the BC model and shows its anticancer activities alone and synergistically and concludes that GNT can have favorable therapeutic advantages when standard drugs are not available in the pharma markets.
Journal ArticleDOI
Palmatine, a Bioactive Protoberberine Alkaloid Isolated from Berberis cretica, Inhibits the Growth of Human Estrogen Receptor-Positive Breast Cancer Cells and Acts Synergistically and Additively with Doxorubicin.
Aneta Grabarska,Paula Wróblewska-Łuczka,Wirginia Kukula-Koch,Jarogniew J. Łuszczki,Eleftherios Kalpoutzakis,Grzegorz Adamczuk,Alexios-Leandros Skaltsounis,Andrzej Stepulak +7 more
TL;DR: Palmatine (PLT) is a natural isoquinoline alkaloid that belongs to the class of protoberberines and exhibits a wide spectrum of pharmacological and biological properties, including anti-cancer activity.
References
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Journal ArticleDOI
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019.
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Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer
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Strategies and challenges for the next generation of antibody–drug conjugates
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