Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and therapeutic interventions.
Ying Han,Kai Yuan,Zhe Wang,Wei-Jian Liu,Zheng-An Lu,Lin Liu,Le Shi,Wei Yan,Jun-Liang Yuan,Jia-Li Li,Jie Shi,Zhongchun Liu,Gaohua Wang,Thomas R. Kosten,Yanping Bao,Lin Lu,Lin Lu +16 more
TLDR
In this paper, the authors summarize recent animal and human studies for neurotrophic properties of severe acute respiratory syndrome coronavirus (SARS-CoV-2) and elucidate potential neuropathogenic mechanisms involved in the viral invasion of the central nervous system as a cause for brain damage and neurological impairments.Abstract:
The coronavirus disease 2019 (COVID-19) pandemic has caused large-scale economic and social losses and worldwide deaths. Although most COVID-19 patients have initially complained of respiratory insufficiency, the presence of neuropsychiatric manifestations is also reported frequently, ranging from headache, hyposmia/anosmia, and neuromuscular dysfunction to stroke, seizure, encephalopathy, altered mental status, and psychiatric disorders, both in the acute phase and in the long term. These neuropsychiatric complications have emerged as a potential indicator of worsened clinical outcomes and poor prognosis, thus contributing to mortality in COVID-19 patients. Their etiology remains largely unclear and probably involves multiple neuroinvasive pathways. Here, we summarize recent animal and human studies for neurotrophic properties of severe acute respiratory syndrome coronavirus (SARS-CoV-2) and elucidate potential neuropathogenic mechanisms involved in the viral invasion of the central nervous system as a cause for brain damage and neurological impairments. We then discuss the potential therapeutic strategy for intervening and preventing neuropsychiatric complications associated with SARS-CoV-2 infection. Time-series monitoring of clinical-neurochemical-radiological progress of neuropsychiatric and neuroimmune complications need implementation in individuals exposed to SARS-CoV-2. The development of a screening, intervention, and therapeutic framework to prevent and reduce neuropsychiatric sequela is urgently needed and crucial for the short- and long-term recovery of COVID-19 patients.read more
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The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
Lisa Bauer,Brigitta M. Laksono,Femke M.S. de Vrij,Steven A. Kushner,Oliver Harschnitz,Debby van Riel +5 more
TL;DR: In this article , the distinction between neuroinvasiveness, neurotropism, and neurovirulence of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is discussed.
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COVID-19 in pregnancy: implications for fetal brain development
TL;DR: Al-Haddad et al. as mentioned in this paper reviewed evidence that SARS-CoV-2 and other viral infections during pregnancy can result in maternal, placental, and fetal immune activation, and ultimately in offspring neurodevelopmental morbidity.
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Long COVID and neuropsychiatric manifestations (Review)
Vasiliki Efstathiou,Maria-Ioanna Stefanou,Marina Demetriou,Nikolaos Siafakas,Michael Makris,Georgios Tsivgoulis,Vassilis Zoumpourlis,Stylianos Kympouropoulos,James T. Tsoporis,Demetrios A. Spandidos,Nikolaos Smyrnis,Emmanouil Rizos +11 more
TL;DR: Interdisciplinary cooperation for the early identification of patients who are at a high risk of persistent neuropsychiatric presentations, beyond COVID-19 recovery, is crucial to ensure that appropriate integrated physical and mental health support is provided, with the aim of mitigating the risks of long-term disability at a societal and individual level.
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“We Were Afraid”: Mental Health Effects of the COVID-19 Pandemic in Two South African Districts
Teurai Rwafa-Ponela,Jessica E. Price,Athini Nyatela,Sizwe Nqakala,Atiya Mosam,Agnes Erzse,Samanta T. Lalla-Edward,Jennifer Hove,Kathleen Kahn,Stephen Tollman,Karen Hofman,Susan Goldstein +11 more
TL;DR: COVID-19 impacts on mental health were consistent among both HCWs and community members in urban and rural alike, and recognition needs to be given to mental health support and treatment for future public health emergencies.
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Neuronal and Non-Neuronal GABA in COVID-19: Relevance for Psychiatry
Adonis Sfera,Karina G. Thomas,Sarvin Sasannia,Jonathan J. Anton,Christina V. Andronescu,Michael Garcia,Dan O. Sfera,Michael Cummings,Zisis Kozlakidis +8 more
TL;DR: A closer look is taken at the pathology emerging from the viral hijacking of non-neuronal GABA and potential interventions for restoring these systems are summarized.
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